Results 31 to 40 of about 28,373 (282)

MECHANISM AND REGULATION OF NONSENSE-MEDIATED MRNA DECAY (NMD), AN ESSENTIAL QUALITY CONTROL SYSTEM OF PLANTS [PDF]

Poljoprivreda, 2008
In eukaryotic cell, various quality control mechanisms have evolved to ensure that only perfect mRNAs could be translated. Nonsense-mediated mRNA decay (NMD) is a quality control system that identifies and eliminates mRNAs containing premature ...
D. Silhavy, Zs. Merai, Z. Kerenyi, A. Benkovics, L. Hiripi   +4 more
doaj  

The evolution and diversity of the nonsense-mediated mRNA decay pathway [version 2; referees: 4 approved]

F1000Research, 2018
Nonsense-mediated mRNA decay is a eukaryotic pathway that degrades transcripts with premature termination codons (PTCs). In most eukaryotes, thousands of transcripts are degraded by NMD, including many important regulators of developmental and stress ...
James P. B. Lloyd
doaj   +1 more source

Towards harmonisation of outcome measures for DMD and SMA within TREAT-NMD; report of three expert workshops: TREAT-NMD/ENMC workshop on outcome measures, 12th--13th May 2007, Naarden, The Netherlands; TREAT-NMD workshop on outcome measures in experimental trials for DMD, 30th June--1st July 2007, Naarden, The Netherlands; conjoint Institute of Myology TREAT-NMD meeting on physical activity monitoring in neuromuscular disorders, 11th July 2007, Paris, France

, 2008
Full title: Towards harmonisation of outcome measures for DMD and SMA within TREAT-NMD; Report of three expert workshops: TREAT-NMD/ENMC Workshop on outcome measures, 12th-13th May 2007, Naarden, The Netherlands; TREAT-NMD Workshop on outcome measures in
Mayhew, A., Messina, S., E. Bertini, E. Mercuri, Bushby, K., K. Bushby, Bertini, E., G. J. Van Ommend, Mercuri, E., Voit, T., V. Straub, F. Muntoni, Muntoni, F., Y. Torrente, the TREAT NMD Neuromuscular Network, A. Mayhew, S. Messina, T. Voit, Straub, V., van Ommen, G. J.   +19 more
core   +1 more source

Investigation of NMD factors in Schizosaccharomyces pombe [PDF]

, 2013
Nonsense Mediated mRNA Decay (NMD) is a translation-coupled mRNA surveillance mechanism which targets aberrant mRNAs harbouring premature termination codons (PTCs).
Piechocki, Kim Suzanne
core   +6 more sources

UPF2 is a critical regulator of liver development, function and regeneration.

PLoS ONE, 2010
BackgroundNonsense-mediated mRNA decay (NMD) is a post-transcriptional RNA surveillance process that facilitates the recognition and destruction of mRNAs bearing premature terminations codons (PTCs).
Lina A Thoren, Gitte A Nørgaard, Joachim Weischenfeldt, Johannes Waage, Janus S Jakobsen, Inge Damgaard, Frida C Bergström, Anna M Blom, Rehannah Borup, Hanne Cathrine Bisgaard, Bo T Porse   +10 more
doaj   +1 more source

A role for nonsense-mediated mRNA decay in plants: pathogen responses are induced in Arabidopsis thaliana NMD mutants.

PLoS ONE, 2012
Nonsense-mediated mRNA decay (NMD) is a conserved mechanism that targets aberrant mRNAs for destruction. NMD has also been found to regulate the expression of large numbers of genes in diverse organisms, although the biological role for this is unclear ...
Samantha Rayson, Luis Arciga-Reyes, Lucie Wootton, Marta De Torres Zabala, William Truman, Neil Graham, Murray Grant, Brendan Davies   +7 more
doaj   +1 more source

Impact of nonsense-mediated mRNA decay on the global expression profile of budding yeast. [PDF]

PLoS Genetics, 2006
Nonsense-mediated mRNA decay (NMD) is a eukaryotic mechanism of RNA surveillance that selectively eliminates aberrant transcripts coding for potentially deleterious proteins. NMD also functions in the normal repertoire of gene expression.
Qiaoning Guan, Wei Zheng, Shijie Tang, Xiaosong Liu, Robert A Zinkel, Kam-Wah Tsui, Brian S Yandell, Michael R Culbertson   +7 more
doaj   +1 more source

NMD-resistant transcripts contain unstructured regions downstream of stop codons compared to UPF1 targets.

, 2018
(A) Using a previously published dataset that identified NMD-resistant and UPF1-targeted transcripts [36], the minimum folding energies (MFE) for bases 16–90 downstream of each stop codon was calculated using RNAslider [49].
Jared P. May (5988455), Xuefeng Yuan (714724), Erika Sawicki (5988458), Anne E. Simon (5988461)   +3 more
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

ClC-1 Inhibition as a Mechanism for Accelerating Skeletal Muscle Recovery After Neuromuscular Block in Rats

Nature Communications
Neuromuscular blocking agents are used commonly to induce skeletal muscle relaxation during surgery. While muscle relaxation facilitates surgical procedures and tracheal intubation, adequate recovery of muscle function after surgery is required to ...
Marianne Skals, Martin Broch-Lips, Martin Brandhøj Skov, Anders Riisager, Judith Ceelen, Ole Bækgaard Nielsen, Sorin J. Brull, Hans D. de Boer, Thomas Holm Pedersen   +8 more
doaj   +1 more source