NMD: Nonsense-Mediated Defense [PDF]
Cell Host & Microbe, 2014 Initially described as an RNA surveillance pathway, nonsense-mediated decay (NMD) is also recognized to function in the regulation of host gene expression. In this issue of Cell Host & Microbe, three studies describe NMD-mediated defense strategies of plants and mammalian cells in response to pathogen infection.
Wachter, Andreas, Hartmann, Lisa
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Effect of a mixture of caffeine and nicotinamide on the solubility of vitamin (B2) in aqueous solution [PDF]
, 2006 The effect of caffeine (CAF) and nicotinamide (NMD) on the solubility of a vitamin B2 derivative (FMN) has been evaluated for mixtures containing either a single hydrotrope (CAF or NMD) or the two hydrotropes simultaneously.
A.A. Hernandez Santiago +22 more
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Large-scale evidence for conservation of NMD candidature across mammals. [PDF]
PLoS ONE, 2010 BACKGROUND: Alternatively-spliced (AS) forms can vary protein function, intracellular localization and post-translational modifications. AS coupled with mRNA nonsense-mediated decay (NMD) can also control the transcript abundance.
David A de Lima Morais, Paul M Harrison
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The Substrates of Nonsense-Mediated mRNA Decay in Caenorhabditis elegans
G3: Genes, Genomes, Genetics, 2018 Nonsense-mediated mRNA decay (NMD) is a conserved pathway that strongly influences eukaryotic gene expression. Inactivating or inhibiting NMD affects the abundance of a substantial fraction of the transcriptome in numerous species.
Virginia S. Muir +2 more
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A Upf3b-mutant mouse model with behavioral and neurogenesis defects. [PDF]
, 2018 Nonsense-mediated RNA decay (NMD) is a highly conserved and selective RNA degradation pathway that acts on RNAs terminating their reading frames in specific contexts.
Cook-Andersen, H +14 more
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Assessing the activity of nonsense-mediated mRNA decay in lung cancer
BMC Medical Genomics, 2017 Background Inhibition of nonsense-mediated mRNA decay (NMD) in tumor cells can suppress tumor growth through expressing new antigens whose mRNAs otherwise are degraded by NMD.
Meng Wang +5 more
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UPF3A is dispensable for nonsense-mediated mRNA decay in mouse pluripotent and somatic cells
Life Science Alliance, 2023 We generated a new Upf3a -inducible knockout mouse model and showed that UPF3A does not repress expressions of NMD target genes in embryonic stem cells, somatic fibroblasts, and multiple tissues from adult mice.
Chengyan Chen +5 more
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Developments in non-mandatory disclosures in annual reports of companies: A case study [PDF]
, 2013 The paper investigates the extent of non-mandatory disclosure of information (NMD) in the annual reports of the 17 companies listed on the South Pacific Stock Exchange (SPSE) in Fiji, a developing country, and whether NMD by these companies has changed ...
Davey, Howard +2 more
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NMD Classifier: A reliable and systematic classification tool for nonsense-mediated decay events. [PDF]
PLoS ONE, 2017 Nonsense-mediated decay (NMD) degrades mRNAs that include premature termination codons to avoid the translation and accumulation of truncated proteins.
Min-Kung Hsu +2 more
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Suppressing nonsense--a surprising function for 5-azacytidine. [PDF]
, 2014 In this issue of EMBO Molecular Medicine, Bhuvanagiri et al report on a chemical means to convert molecular junk into gold. They identify a chemical inhibitor of a quality control pathway that is best known for its ability to clear cells of rubbish, but ...
Shao, Ada, Wilkinson, Miles F
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