Results 21 to 30 of about 28,373 (282)

Assessing the activity of nonsense-mediated mRNA decay in lung cancer

BMC Medical Genomics, 2017
Background Inhibition of nonsense-mediated mRNA decay (NMD) in tumor cells can suppress tumor growth through expressing new antigens whose mRNAs otherwise are degraded by NMD.
Meng Wang, Peiwei Zhang, Yufei Zhu, Xiangyin Kong, Zhenguo Zhang, Landian Hu   +5 more
doaj   +1 more source

The Substrates of Nonsense-Mediated mRNA Decay in Caenorhabditis elegans

G3: Genes, Genomes, Genetics, 2018
Nonsense-mediated mRNA decay (NMD) is a conserved pathway that strongly influences eukaryotic gene expression. Inactivating or inhibiting NMD affects the abundance of a substantial fraction of the transcriptome in numerous species.
Virginia S. Muir, Audrey P. Gasch, Philip Anderson   +2 more
doaj   +1 more source

Human NMD ensues independently of stable ribosome stalling [PDF]

, 2020
Nonsense-mediated mRNA decay (NMD) was thought to ensue when ribosomes fail to terminate translation properly. However, the authors observe similar ribosome occupancy at stop codons of NMD sensitive and insensitive mRNAs, showing that human NMD is not ...
Annibaldis, Giuditta, Karousis, Evangelos D., Mühlemann, Oliver, Evangelos D. Karousis, Lukas-Adrian Gurzeler, Giuditta Annibaldis, René Dreos, Dreos, René, Oliver Mühlemann, Gurzeler, Lukas Adrian   +9 more
core   +2 more sources

NMD Classifier: A reliable and systematic classification tool for nonsense-mediated decay events. [PDF]

PLoS ONE, 2017
Nonsense-mediated decay (NMD) degrades mRNAs that include premature termination codons to avoid the translation and accumulation of truncated proteins.
Min-Kung Hsu, Hsuan-Yu Lin, Feng-Chi Chen   +2 more
doaj   +1 more source

UPF3A is dispensable for nonsense-mediated mRNA decay in mouse pluripotent and somatic cells

Life Science Alliance, 2023
We generated a new Upf3a -inducible knockout mouse model and showed that UPF3A does not repress expressions of NMD target genes in embryonic stem cells, somatic fibroblasts, and multiple tissues from adult mice.
Chengyan Chen, Yanmin Shen, Luqian Li, Yaoxin Ren, Zhao-Qi Wang, Tangliang Li   +5 more
doaj   +1 more source

Post-transcriptional regulation of 5-lipoxygenase mRNA expression via alternative splicing and nonsense-mediated mRNA decay [PDF]

, 2012
5-Lipoxygenase (5-LO) catalyzes the two initial steps in the biosynthesis of leukotrienes (LT), a group of inflammatory lipid mediators derived from arachidonic acid.
Laura Pufahl (182448), Manuel Grez, Grez, Manuel, Ochs, Meike J., Sorg, Bernd L., Beatrix Suess (17019), Sorg Bernd L., Laura Pufahl, Sorg, Bernd Lothar, Bernd L Sorg, Beatrix Suess, Bernd L. Sorg (182441), Suess Beatrix, Grez Manuel, Steinhilber Dieter, Dieter Steinhilber (182458), Meike J. Ochs (182432), Suess, Beatrix, Manuel Grez (182453), Dieter Steinhilber, Meike J Ochs, Pufahl, Laura, Süß, Beatrix, Pufahl Laura, Ochs, Meike, Steinhilber, Dieter, Ochs Meike J.   +26 more
core   +2 more sources

The Meaning of NMD: Translate or Perish [PDF]

Trends in Genetics, 2016
Premature translation termination leads to a reduced mRNA level in all types of organisms. In eukaryotes, the phenomenon is known as nonsense-mediated mRNA decay (NMD). This is commonly regarded as the output of a specific surveillance and destruction mechanism that is activated by the presence of a premature translation termination codon (PTC) in an ...
Saverio, Brogna, Tina, McLeod, Marija, Petric   +2 more
openaire   +2 more sources

Comparison of countries in European region according to risk factors of noncommunicable diseases by APLOCO method

Adıyaman Üniversitesi Sağlık Bilimleri Dergisi
Aim: The aim of the study was to compare countries in the WHO European Region according to key risk factors of NCDs.Materials and Methods: Target population of study consists of 37 European Region countries. Weights of key risk factors were determined by
Tevfik Bulut
doaj   +1 more source

On the Equivalence of NMDS Codes

IEEE Transactions on Information Theory
An $[n,k,d]$ linear code is said to be maximum distance separable (MDS) or almost maximum distance separable (AMDS) if $d=n-k+1$ or $d=n-k$, respectively. If a code and its dual code are both AMDS, then the code is said to be near maximum distance separable (NMDS).
Jianbing Lu, Yue Zhou 0001
openaire   +3 more sources

The Diagnosis And Management Of Duchenne Muscular Dystrophy: A Guide for Families - TREAT-NMD

, 2023
<p>Translation and adaptation of the TREAT-NMD USA book "The Diagnosis And Management Of Duchenne Muscular Dystrophy: A Guide for Families" into the Portuguese context by João Miguel Alves Ferreira</p><p><strong>PT < ...
Alves Ferreira, João Miguel
core   +1 more source