Results 11 to 20 of about 28,373 (282)
Nanopore sequencing reveals endogenous NMD-targeted isoforms in human cells [PDF]
Genome Biology, 2021 Background Nonsense-mediated mRNA decay (NMD) is a eukaryotic, translation-dependent degradation pathway that targets mRNAs with premature termination codons and also regulates the expression of some mRNAs that encode full-length proteins.
Evangelos D. Karousis +3 more
doaj +3 more sources
NMD: Nonsense-Mediated Defense [PDF]
Cell Host & Microbe, 2014 Initially described as an RNA surveillance pathway, nonsense-mediated decay (NMD) is also recognized to function in the regulation of host gene expression. In this issue of Cell Host & Microbe, three studies describe NMD-mediated defense strategies of plants and mammalian cells in response to pathogen infection.
Wachter, Andreas, Hartmann, Lisa
openaire +4 more sources
Ethics at the edge of translation: the work of the TREAT-NMD Project Ethics Council [PDF]
We will describe the work of the TREAT-NMD Project Ethics Council (PEC). The ethics council was instituted to examine and advise on ethical issues which arise out of translational research in neuromuscular disorders and particularly, the work of TREAT ...
McCormack P, Woods S
core +5 more sources
Simplified Nonsense: New Methods for Interrogating NMD [PDF]
, 2023 Nonsense mediated decay (NMD) is a pathway that regulates RNA turnover. Since its discovery, this pathway has been implicated in a variety of cellular processes ranging from differentiation to the restriction of viral replication.
Alalam, Hanna
core +1 more source
Disease Models & Mechanisms, 2020 Nonsense-mediated mRNA decay (NMD) targets mRNAs that contain a premature termination codon (PTC) for degradation, preventing their translation. By altering the expression of PTC-containing mRNAs, NMD modulates the inheritance pattern and severity of ...
Josh Echols +6 more
doaj +1 more source
Compound C inhibits nonsense-mediated RNA decay independently of AMPK. [PDF]
PLoS ONE, 2018 The nonsense mediated RNA decay (NMD) pathway safeguards the integrity of the transcriptome by targeting mRNAs with premature translation termination codons (PTCs) for degradation.
Abigael Cheruiyot +5 more
doaj +1 more source
Mapping genetic variants for nonsense-mediated mRNA decay regulation across human tissues
Genome Biology, 2023 Background Nonsense-mediated mRNA decay (NMD) was originally conceived as an mRNA surveillance mechanism to prevent the production of potentially deleterious truncated proteins. Research also shows NMD is an important post-transcriptional gene regulation
Bo Sun, Liang Chen
doaj +1 more source
Effect of a mixture of caffeine and nicotinamide on the solubility of vitamin (B2) in aqueous solution [PDF]
, 2006 The effect of caffeine (CAF) and nicotinamide (NMD) on the solubility of a vitamin B2 derivative (FMN) has been evaluated for mixtures containing either a single hydrotrope (CAF or NMD) or the two hydrotropes simultaneously.
Davies, David B. +3 more
core +1 more source
What makes an NMD target? Identification and characterization of NMD sensitive endogenous transcripts in human cells [PDF]
, 2016 Nonsense-mediated mRNA decay (NMD) was initially described as a quality control mechanism clearing transcripts harboring a premature termination codon (PTC) from the cell.
Mühlemann, Oliver
core +3 more sources
Large-scale evidence for conservation of NMD candidature across mammals. [PDF]
PLoS ONE, 2010 BACKGROUND: Alternatively-spliced (AS) forms can vary protein function, intracellular localization and post-translational modifications. AS coupled with mRNA nonsense-mediated decay (NMD) can also control the transcript abundance.
David A de Lima Morais, Paul M Harrison
doaj +1 more source