AUTOIMMUNE & INFLAMMATORY NMD [PDF]
Neuromuscular Disorders, 2021 K. Alrasheed +5 more
+18 more sources
Nonsense-mediated mRNA decay uses complementary mechanisms to suppress mRNA and protein accumulation
Life Science Alliance, 2022 A reporter system for quantitative measurements of NMD-sensitive mRNA and protein levels in mammalian cells shows that NMD suppresses protein levels to a greater degree than RNA levels. Nonsense-mediated mRNA decay (NMD) is an essential, highly conserved
Dylan B Udy, Robert K Bradley
doaj +1 more source
Disease Models & Mechanisms, 2020 Nonsense-mediated mRNA decay (NMD) targets mRNAs that contain a premature termination codon (PTC) for degradation, preventing their translation. By altering the expression of PTC-containing mRNAs, NMD modulates the inheritance pattern and severity of ...
Josh Echols +6 more
doaj +1 more source
The Importance of Muscle and Nerve Biopsies in the Diagnosis of Neuromuscular Diseases
Forbes Tıp Dergisi, 2020 Although the etiopathogenesis of infections has been largely illuminated by technical and scientific developments in the past century; many issues are still not clear today. The motto 'there is no disease, there is a patient' expressed by our instructors
Gülden Diniz
doaj +1 more source
Nanopore sequencing reveals endogenous NMD-targeted isoforms in human cells
Genome Biology, 2021 Background Nonsense-mediated mRNA decay (NMD) is a eukaryotic, translation-dependent degradation pathway that targets mRNAs with premature termination codons and also regulates the expression of some mRNAs that encode full-length proteins.
Evangelos D. Karousis +3 more
doaj +1 more source
Identification and characterization of novel factors that act in the nonsense-mediated mRNA decay pathway in nematodes, flies and mammals [PDF]
, 2014 Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism that degrades mRNAs harboring premature termination codons (PTCs). We have conducted a genome-wide RNAi screen in Caenorhabditis elegans that resulted in the identification of five novel NMD ...
Ailion M +8 more
core +2 more sources
Identification and functional analysis of novel phosphorylation sites in the RNA surveillance protein Upf1. [PDF]
, 2013 One third of inherited genetic diseases are caused by mRNAs harboring premature termination codons as a result of nonsense mutations. These aberrant mRNAs are degraded by the Nonsense-Mediated mRNA Decay (NMD) pathway.
Bracho, Dina P +11 more
core +1 more source
Mapping genetic variants for nonsense-mediated mRNA decay regulation across human tissues
Genome Biology, 2023 Background Nonsense-mediated mRNA decay (NMD) was originally conceived as an mRNA surveillance mechanism to prevent the production of potentially deleterious truncated proteins. Research also shows NMD is an important post-transcriptional gene regulation
Bo Sun, Liang Chen
doaj +1 more source
Hyperphosphorylation amplifies UPF1 activity to resolve stalls in nonsense-mediated mRNA decay. [PDF]
, 2016 Many gene expression factors contain repetitive phosphorylation sites for single kinases, but the functional significance is poorly understood. Here we present evidence for hyperphosphorylation as a mechanism allowing UPF1, the central factor in nonsense-
Durand, Sébastien +2 more
core +3 more sources