Ionotropic Glutamate Receptors in Epilepsy: A Review Focusing on AMPA and NMDA Receptors
Biomolecules, 2020 It is widely accepted that glutamate-mediated neuronal hyperexcitation plays a causative role in eliciting seizures. Among glutamate receptors, the roles of N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA ...
Takahisa Hanada
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Visual Attention Decits in Schizophrenia Can Arise From Inhibitory Dysfunction in Thalamus or Cortex [PDF]
Computational Psychiatry, 2018 Schizophrenia is associated with diverse cognitive deficits, including disorders of attention-related oculomotor behavior. At the structural level, schizophrenia is associated with abnormal inhibitory control in the circuit linking cortex and thalamus ...
Yohan J. John +3 more
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Activation of NMDA receptors and the mechanism of inhibition by ifenprodil
Nature, 2016 The physiology of N-methyl-d-aspartate (NMDA) receptors is fundamental to brain development and function. NMDA receptors are ionotropic glutamate receptors that function as heterotetramers composed mainly of GluN1 and GluN2 subunits.
Erkan Karakas +2 more
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NMDA receptor structures reveal subunit arrangement and pore architecture
Nature, 2014 N-methyl-d-aspartate (NMDA) receptors are Hebbian-like coincidence detectors, requiring binding of glycine and glutamate in combination with the relief of voltage-dependent magnesium block to open an ion conductive pore across the membrane bilayer ...
April Goehring, Juan Du, Xianqiang Song
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Mechanism of NMDA receptor channel block by MK-801 and memantine
Nature, 2018 Xianqiang Song +2 more
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Effects of D-Serine and MK-801 on Neuropathic Pain and Functional Recovery in a Rat Model of Spinal Cord Injury [PDF]
Neurospine, 2022 Objective Neuropathic pain is a common secondary complication of spinal cord injury (SCI). N-methyl-D-aspartate (NMDA) receptor activation is critical for hypersensitivity in neuropathic pain.
Dongwoo Yu +8 more
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Frontiers in Endocrinology, 2022 Glaucoma is the leading cause of irreversible blindness. The progressive degeneration of retinal ganglion cells (RGCs) is the major characteristic of glaucoma. Even though the control of intraocular pressure could delay the loss of RGCs, current clinical
Chao Wang +21 more
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Maropitant ou cetamina para o controle da dor em cadelas submetidas à ovariohisterectomia
Pubvet, 2022 O controle da dor está diretamente relacionado ao bem-estar e a recuperação pós-operatória do paciente. O presente estudo objetivou avaliar a eficácia analgésica do citrato de Maropitant (GM) e Cetamina (GC), em bolus, seguidos de infusão contínua, em ...
Ayme Fernanda Favaretto +3 more
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Evaluation of the anticonvulsant effect of carvacrol in Pentylenetetrazole (PTZ)-induced seizures in male mice: N-Methyl-D-Aspartic Acid receptor role [PDF]
مجله پزشکی دانشگاه علوم پزشکی تبریز, 2022 Background. Epilepsy is one of the most common neurological disorders after stroke. Due to the side effects and poor response of conventional anticonvulsant drugs, researchers have turned their attention to find new drugs.
Hossein Amini-khoei +5 more
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Acta Medica Alanya, 2021 Aim: The GRIN2D gene mutation causes severe forms of epileptic encephalopathy. NMDAR antagonists and magnesium sulfate could be useful as adjunctive therapy to control seizures in individuals with GRIN2D encephalopathy.
Nadide Cemre Randa, Gültekin Kutluk
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