Effects of D-Serine and MK-801 on Neuropathic Pain and Functional Recovery in a Rat Model of Spinal Cord Injury [PDF]
Objective Neuropathic pain is a common secondary complication of spinal cord injury (SCI). N-methyl-D-aspartate (NMDA) receptor activation is critical for hypersensitivity in neuropathic pain.
Dongwoo Yu +8 more
doaj +1 more source
Maropitant ou cetamina para o controle da dor em cadelas submetidas à ovariohisterectomia
O controle da dor está diretamente relacionado ao bem-estar e a recuperação pós-operatória do paciente. O presente estudo objetivou avaliar a eficácia analgésica do citrato de Maropitant (GM) e Cetamina (GC), em bolus, seguidos de infusão contínua, em ...
Ayme Fernanda Favaretto +3 more
doaj +1 more source
Glaucoma is the leading cause of irreversible blindness. The progressive degeneration of retinal ganglion cells (RGCs) is the major characteristic of glaucoma. Even though the control of intraocular pressure could delay the loss of RGCs, current clinical
Chao Wang +21 more
doaj +1 more source
Evaluation of the anticonvulsant effect of carvacrol in Pentylenetetrazole (PTZ)-induced seizures in male mice: N-Methyl-D-Aspartic Acid receptor role [PDF]
Background. Epilepsy is one of the most common neurological disorders after stroke. Due to the side effects and poor response of conventional anticonvulsant drugs, researchers have turned their attention to find new drugs.
Hossein Amini-khoei +5 more
doaj +1 more source
Aim: The GRIN2D gene mutation causes severe forms of epileptic encephalopathy. NMDAR antagonists and magnesium sulfate could be useful as adjunctive therapy to control seizures in individuals with GRIN2D encephalopathy.
Nadide Cemre Randa, Gültekin Kutluk
doaj +1 more source
Effect of MK-801 Treatment and Endurance Training on Angiogenic Response in Cardiac Muscle [PDF]
PURPOSE The purpose of this study was to investigate the effects of regular endurance exercise on the changes of angiogenic biomarkers in myocardial tissues of the schizophrenia-induced rats. METHODS Twenty-one SD rats were randomly assigned to CON (n=7),
Youngpyo Hong, Hyoseong Yeo
doaj +1 more source
Новый взгляд на патогенез депрессии: возможно ли появление быстродействующих антидепрессантов?
Рекуррентное депрессивное расстройство является одним из самых распространенных и высокозатратных психических заболеваний в мире. На настоящий момент актуальна моноаминовая теория депрессии, однако открытие около 20 лет назад антидепрессивных свойств
Мосолов, С.Н. +1 more
doaj +1 more source
Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is a type of autoimmune encephalitis (AE) characterized by antibodies against NMDA receptor. As the most common AE, anti-NMDAR encephalitis affects 54% ~ 80% of patients with AE.
Hongfei Xue +8 more
doaj +1 more source
Ionotropic Glutamate Receptors in Epilepsy: A Review Focusing on AMPA and NMDA Receptors
It is widely accepted that glutamate-mediated neuronal hyperexcitation plays a causative role in eliciting seizures. Among glutamate receptors, the roles of N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA ...
Takahisa Hanada
doaj +1 more source
Inhibition of Food Intake by PACAP in the Hypothalamic Ventromedial Nuclei is Mediated by NMDA Receptors [PDF]
Central injections of pituitary adenylate cyclase-activating polypeptide (PACAP) into the ventromedial nuclei (VMN) of the hypothalamus produce hypophagia that is dependent upon the PAC1 receptor; however, the signaling downstream of this receptor in the
Choi, Sujean +3 more
core +2 more sources

