High- and low-conductance NMDA receptors are present in layer 4 spiny stellate and layer 2/3 pyramidal neurons of mouse barrel cortex [PDF]
Physiological Reports, 30th Dec. 2016, Vol. 4 no. e13051, 2016 NMDA receptors are ion channels activated by the neurotransmitter glutamate in the mammalian brain and are important in synaptic function and plasticity, but are also found in extrasynaptic locations and influence neuronal excitability. There are different NMDA receptor subtypes which differ in their single-channel conductance.
Scheppach, Christian
arxiv +3 more sources
Effects of D-Serine and MK-801 on Neuropathic Pain and Functional Recovery in a Rat Model of Spinal Cord Injury [PDF]
Neurospine, 2022 Objective Neuropathic pain is a common secondary complication of spinal cord injury (SCI). N-methyl-D-aspartate (NMDA) receptor activation is critical for hypersensitivity in neuropathic pain.
Dongwoo Yu +8 more
doaj +1 more source
Evaluation of the anticonvulsant effect of carvacrol in Pentylenetetrazole (PTZ)-induced seizures in male mice: N-Methyl-D-Aspartic Acid receptor role [PDF]
مجله پزشکی دانشگاه علوم پزشکی تبریز, 2022 Background. Epilepsy is one of the most common neurological disorders after stroke. Due to the side effects and poor response of conventional anticonvulsant drugs, researchers have turned their attention to find new drugs.
Hossein Amini-khoei +5 more
doaj +1 more source
Frontiers in Endocrinology, 2022 Glaucoma is the leading cause of irreversible blindness. The progressive degeneration of retinal ganglion cells (RGCs) is the major characteristic of glaucoma. Even though the control of intraocular pressure could delay the loss of RGCs, current clinical
Chao Wang +21 more
doaj +1 more source
Maropitant ou cetamina para o controle da dor em cadelas submetidas à ovariohisterectomia
Pubvet, 2022 O controle da dor está diretamente relacionado ao bem-estar e a recuperação pós-operatória do paciente. O presente estudo objetivou avaliar a eficácia analgésica do citrato de Maropitant (GM) e Cetamina (GC), em bolus, seguidos de infusão contínua, em ...
Ayme Fernanda Favaretto +3 more
doaj +1 more source
NMDA Receptors in Astrocytes [PDF]
Neurochemical Research, 2019 Astrocytes support glutamatergic neurotransmission in the central nervous system through multiple mechanisms which include: (i) glutamate clearance and control over glutamate spillover due to operation of glutamate transporters; (ii) supply of obligatory glutamate precursor glutamine via operation of glutamate-glutamine shuttle; (iii) supply of L ...
Alexandr Chvátal +3 more
openaire +6 more sources
Effect of MK-801 Treatment and Endurance Training on Angiogenic Response in Cardiac Muscle [PDF]
운동과학, 2019 PURPOSE The purpose of this study was to investigate the effects of regular endurance exercise on the changes of angiogenic biomarkers in myocardial tissues of the schizophrenia-induced rats. METHODS Twenty-one SD rats were randomly assigned to CON (n=7),
Youngpyo Hong, Hyoseong Yeo
doaj +1 more source
Ionotropic Glutamate Receptors in Epilepsy: A Review Focusing on AMPA and NMDA Receptors
Biomolecules, 2020 It is widely accepted that glutamate-mediated neuronal hyperexcitation plays a causative role in eliciting seizures. Among glutamate receptors, the roles of N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA ...
Takahisa Hanada
doaj +1 more source
Новый взгляд на патогенез депрессии: возможно ли появление быстродействующих антидепрессантов?
Современная терапия психических расстройств, 2020 Рекуррентное депрессивное расстройство является одним из самых распространенных и высокозатратных психических заболеваний в мире. На настоящий момент актуальна моноаминовая теория депрессии, однако открытие около 20 лет назад антидепрессивных свойств
Мосолов, С.Н. +1 more
doaj +1 more source
Establishment of an adult zebrafish model of retinal neurodegeneration induced by NMDA [PDF]
International Journal of Ophthalmology, 2019 AIM: To establish a model of retinal neurodegeneration induced by N-Methyl-D-aspartic acid (NMDA) in adult zebrafish. METHODS: We compared the effects of three different NMDA delivery methods on retinal neurodegeneration in adult zebrafish: immersion (I.
Zhi-Wen Luo +10 more
doaj +1 more source