Results 211 to 220 of about 246,656 (358)

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Evaluation and experimental monitoring of calcium in plasma membrane inner nanoscale cytoplasm regions. [PDF]

Commun Biol
Antonov SM, Sibarov DA.
europepmc   +1 more source

Psychotic Symptoms Related Anti NMDA Receptor in Ovarian Teratoma

, 2020
Ester G Panserga, Patricia Wulandari, Rachmat Hidayat   +2 more
openalex   +2 more sources

Myeloid PD‐1 Regulates Astrocyte Development and Leads to Active Behaviours

Cell Proliferation, EarlyView.
During early neurodevelopment, PD‐1 ablation in myeloid cells influences myeloid proliferation/differentiation and causes sustained astrocyte overproliferation. PD‐1f/f; LysM‐Cre mice showed elevated astrocyte gene expression and behavioural changes.
Jie Qin, Chong Wang, Sihan Li, Yanyan Wang, Tingting He, Jianwei Jiao, Fen Ji   +6 more
wiley   +1 more source

Kynurenine Pathway Dysregulation in Parkinson's Disease: Insights for Disease Modulation and Therapy. [PDF]

Int J Tryptophan Res
Chakkarwar VA, Kulkarni YA.
europepmc   +1 more source

Spreading depolarization and its influence on epileptiform activity

Epilepsia, EarlyView.
Abstract Spreading depolarization (SD) is a transient disruption of electrographic activity that slowly propagates through the gray matter by chemical contiguity, and it is characterized by a large depolarization of neurons and glial cells. SD, which is associated with massive changes in ion homeostasis, including extreme increases in [K+]o, was shown ...
Maxime Lévesque, Rüdiger Köhling, Massimo Avoli   +2 more
wiley   +1 more source

Characterizing Spatial Associations Between GluCEST MRI and Neurotransmitter Receptor Density in the Human Cortex. [PDF]

Hum Brain Mapp
Pecsok MK, Shafiei G, Atkins A, Calkins ME, Gur RC, Reddy Nanga RP, Reddy R, Matyi MA, Stifelman J, Robinson H, Baller EB, Shinohara RT, Ruparel K, Linn KA, Wolf DH, Satterthwaite TD, McMillan CT, Roalf D.   +17 more
europepmc   +1 more source

Die neuroprotektive Wirkung der NMDA-Rezeptorantagonisten CGS, Memantin und Ifenprodil, sowie Roscovitin und NMDA auf die hypoxiebedingte Zellschädigung an embryonalen kortikalen Zellen von Ratten

, 2015
Holtkamp, Johanna
openalex   +1 more source

Neuronal hyperexcitability: A key to unraveling hippocampal synaptic dysfunction in Lafora disease

Epilepsia, EarlyView.
Abstract Background and Objective Lafora disease (LD) is a rare progressive disorder caused by mutations in the EPM2A or EPM2B genes, characterized by the accumulation of Lafora bodies, drug‐resistant epilepsy, and cognitive decline. To investigate the early molecular mechanisms of LD, we studied electrophysiological changes in the dentate gyrus (DG ...
Cinzia Costa, Laura Bellingacci, Jacopo Canonichesi, Valentina Imperatore, Anna Aurora Taddei, Luis Zafra‐Puerta, Nerea Iglesias‐Cabeza, Paolo Prontera, Andrea Mancini, Massimiliano Di Filippo, Alessandro Tozzi, Katiuscia Martinello, Marta Barzasi, Fabrizio Gardoni, Marina P. Sánchez, José M. Serratosa, Lucilla Parnetti, Miriam Sciaccaluga   +17 more
wiley   +1 more source

A neuroactive steroid with a therapeutically interesting constellation of actions at GABAA and NMDA receptors

, 2020
Luke H. Ziolkowski, Isaac Mordukhovich, Daniel M. Chen, Mariangela Chisari, Hong-Jin Shu, Peter Lambert, Mingxing Qian, Charles F. Zorumski, Douglas F. Covey, Steven Mennerick   +9 more
openalex   +2 more sources