Results 241 to 250 of about 217,671 (368)

The universal role of adaptive transcription in health and disease

The FEBS Journal, EarlyView.
Adaptive transcription via molecules such as CREB, MEF2, SRF, AP1, Nr4a1, and Egr1 constitutes a universal mechanism for directed cell state transitions in health and disease. These molecules are involved in physiological adaptation processes, pathological maladaptations, curative adaptations, and development of resistance to treatment.
Thomas Lissek
wiley   +1 more source

An adamantane‐based ligand as a novel chemical tool for thermosensory TRPM8 channel therapeutic modulation

The FEBS Journal, EarlyView.
Transient receptor potential cation channel subfamily M member 8 (TRPM8) is a cationic thermosensory channel crucial for cold sensation and menthol response. TRPM8 dysfunction leads to sensory symptoms such as cold allodynia. Targeting TRPM8 is important for treating diseases like peripheral neuropathies and cancer.
Angela Lamberti, Silvio Aprile, David Cabañero, Fabio Travagin, Laura Butron, Gregorio Fernández‐Ballester, Gian Cesare Tron, Asia Fernández‐Carvajal, Antonio Ferrer‐Montiel, Ubaldina Galli   +9 more
wiley   +1 more source

Selective inhibition of NMDA receptor function by nootropic drugs: evaluation of the sites of action using mRNA-injected Xenopus oocyte responses and [3H]MK-801 binding assay.

, 1991
Shuji Kaneko, Masunobu Sugimura, Hideki Takahashi, Tatsuo Inoue, Masamichi Satoh   +4 more
openalex   +1 more source

NMDA-induced lesions of the amygdaloid complex block the retention-enhancing effect of posttraining epinephrine [PDF]

, 1991
Labry Cahill, James L. McGaugh
openalex   +1 more source

Bridging the gap: insights into sensorimotor deficits in NMDA receptor antibody encephalitis. [PDF]

J Clin Invest
Opal P, Swanson GT.
europepmc   +1 more source

Natural aminosterols inhibit NMDA receptors with low nanomolar potency

The FEBS Journal, EarlyView.
Misfunction of N‐methyl‐D‐aspartate (NMDA) receptors is associated with many brain disorders, making them primary targets for drug discovery. Trodusquemine and other natural aminosterols inhibit NMDA receptors with low nanomolar potency through binding to the cell membranes followed by interaction with the channels.
Giulia Fani, Elisabetta Coppi, Silvia Errico, Federica Cherchi, Martina Gennari, Denise Barbut, Michele Vendruscolo, Michael Zasloff, Anna Maria Pugliese, Fabrizio Chiti   +9 more
wiley   +1 more source

Investigating the Impact of NMDA Receptor Organization and Biological Sex in the APPswe/PS1dE9 Mouse Model of Alzheimer's Disease. [PDF]

Int J Mol Sci
Hadzibegovic S, Bontempi B, Nicole O.
europepmc   +1 more source

The effect of centrally acting myorelaxants on NMDA receptor‐mediated synaptic transmission in the immature rat spinal cord in vitro [PDF]

, 1992
Richard J. Siarey, S.K. Long, Richard H. Evans   +2 more
openalex   +1 more source

d‐amino acids: new functional insights

The FEBS Journal, EarlyView.
This review explores recent advances in understanding d‐amino acids (d‐AAs) and their pivotal roles across organisms, from plants to humans. d‐AAs have been implicated in key physiological processes, including cancer, inflammation, immune regulation, kidney disease, diabetes, and nervous system function.
Loredano Pollegioni, Natasa Kustrimovic, Luciano Piubelli, Elena Rosini, Valentina Rabattoni, Silvia Sacchi   +5 more
wiley   +1 more source

Future Perspectives of NMDAR in CNS Disorders. [PDF]

Molecules
Capó T, Rebassa JB, Raïch I, Lillo J, Badia P, Navarro G, Reyes-Resina I.   +6 more
europepmc   +1 more source