Results 41 to 50 of about 217,671 (368)

A companion to the preclinical common data elements and case report forms for neuropathology studies in epilepsy research. A report of the TASK3 WG2 Neuropathology Working Group of the ILAE/AES Joint Translational Task Force

Epilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force initiated the TASK3 working group to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Eleonora Aronica, Devin K. Binder, Meinrad Drexel, Chrysanthy Ikonomidou, Shilpa D. Kadam, Guenther Sperk, Christian Steinhäuser   +6 more
wiley   +1 more source

Role of NMDA conductance in average firing rate shifts caused by external periodic forcing [PDF]

Phys. Rev. E 101, 052408 (2020), 2018
A widely accepted view of computations in the brain relies on population coding, where the neural ensemble firing rate is modulated in a stable manner to transmit information and perform various cognitive tasks. At the same time, oscillatory neural activity is specifically modulated in frequency, coherence and power during cognitive performance.
arxiv   +1 more source

The NMDA agonist D-cycloserine facilitates fear memory consolidation in humans [PDF]

, 2009
Animal research suggests that the consolidation of fear and extinction memories depends on N-methyl D-aspartate (NMDA)- type glutamate receptors.
Amaral, Anthony, Ashburner, Bauer, Beatrice Holt, Benedetto De Martino, Blair, Bond, Bouton, Buchel, Carmichael, Carter, Christian Büchel, Corcoran, Corcoran, Critchley, Davis, Deichmann, Deichmann, Delamater, Duvernoy, Ekman, Frankland, Friston, Friston, Gould, Guastella, Heresco-Levy, Hetem, Hofmann, Honey, Izquierdo, Ji, Kalisch, Kalisch, Kalisch, Kalisch, Karcz-Kubicha, Kim, Klodzinska, Kushner, LaBar, LaBar, Ledgerwood, Lee, Mao, Maren, Martin, McGaugh, Morris, Myers, Parwani, Pavlov, Penny, Phelps, Predrag Petrovic, Raffael Kalisch, Raymond J. Dolan, Ressler, Rodrigues, Rubin, Runyan, Scavio, Schafe, Seymour, Sheinin, Sotres-Bayon, Spielberger, Stefan Klöppel, Stewart, Takehara, Trevisan, van Berckel, Vervliet, Walker, Yang, Zhu, Zorawski   +77 more
core   +2 more sources

A family of photoswitchable NMDA receptors [PDF]

eLife, 2016
NMDA receptors, which regulate synaptic strength and are implicated in learning and memory, consist of several subtypes with distinct subunit compositions and functional properties. To enable spatiotemporally defined, rapid and reproducible manipulation of function of specific subtypes, we engineered a set of photoswitchable GluN subunits ('LiGluNs ...
Stephanie Szobota, Michael A. Kienzler, Dirk Trauner, Elizabeth C. Carroll, Andreas Reiner, Shai Berlin, Tong Xiao, Alice Guyon, Alice Guyon, Ehud Y. Isacoff, Ehud Y. Isacoff, Ehud Y. Isacoff   +11 more
openaire   +6 more sources

A companion to the preclinical common data elements for rodent models of pediatric acquired epilepsy: A report of the TASK3‐WG1B, Pediatric and Genetic Models Working Group of the ILAE/AES Joint Translational Task Force

Epilepsia Open, EarlyView., 2022
Abstract Epilepsy syndromes during the early years of life may be attributed to an acquired insult, such as hypoxic–ischemic injury, infection, status epilepticus, or brain trauma. These conditions are frequently modeled in experimental rodents to delineate mechanisms of epileptogenesis and investigate novel therapeutic strategies.
Anna‐Maria Katsarou, Hana Kubova, Stéphane Auvin, Massimo Mantegazza, Melissa Barker‐Haliski, Aristea S. Galanopoulou, Christopher A. Reid, Bridgette D. Semple   +7 more
wiley   +1 more source

Three-level multilevel simulation of the neuroreceptor function of NMDA [PDF]

arXiv, 2021
We present a new multiscale method to study the N-Methyl-D-Aspartate (NMDA) neuroreceptor starting from the reconstruction of its crystallographic structure. Thanks to the combination of homology modelling, Molecular Dynamics and Lattice Boltzmann simulations, we analyse the allosteric transition of NDMA upon ligand binding and compute the receptor ...
arxiv  

Mitochondrial potassium channel opener diazoxide preserves neuronal-vascular function after cerebral ischemia in newborn pigs [PDF]

, 1999
Background and Purpose-N-Methyl-D-aspartate (NMDA) elicits neuronally mediated cerebral arteriolar vasodilation that is reduced by ischemia/reperfusion (I/R).
David W. Busija, Ferenc Bari, Ferenc Domoki, James V. Perciaccante, Roland Veltkamp   +4 more
core   +1 more source

Acute Effects of Intravenous Sub-Anesthetic Doses of Ketamine and Intranasal Inhaled Esketamine on Suicidal Ideation: A Systematic Review and Meta-Analysis

Neuropsychiatric Disease and Treatment, 2023
Cheng-Chuan Chen,1,* Na Zhou,2,* Na Hu,1 Jian-Guo Feng,1 Xiao-Bin Wang1 1Department of Anesthesiology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, People’s Republic of China; 2School of Nursing, Southwest ...
Chen CC, Zhou N, Hu N, Feng JG, Wang XB
doaj  

Postnatal functional inactivation of the ventral subiculum enhances dopaminergic responses in the core part of the nucleus accumbens following ketamine injection in adult rats [PDF]

, 2020
For almost two decades schizophrenia has been considered to be a functional disconnection disorder. This functional disconnectivity between several brain regions could have a neurodevelopmental origin. Various approaches suggest the ventral subiculum (SUB) is a particular target region for neurodevelopemental disturbances in schizophrenia.
arxiv   +1 more source

GABA\u3csub\u3eA\u3c/sub\u3e and excitatory amino acid receptors in dorsomedial hypothalamus and heart rate in rats [PDF]

, 1991
We have previously shown that microinjection of drugs that interfere with the function of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) into the hypothalamus produces cardiorespiratory and behavioral changes resembling those seen in ...
DiMicco, Joseph A., Soltis, Robert P.
core   +2 more sources