Results 71 to 80 of about 154,177 (308)

Computational study of NMDA conductance and cortical oscillations in schizophrenia

Frontiers in Computational Neuroscience, 2014
N-methyl-D-aspartate (NMDA) receptor hypofunction has been implicated in the pathophysiology of schizophrenia. The illness is also characterized by gamma oscillatory disturbances, which can be evaluated with precise frequency specificity employing ...
Kubra eKomek Kirli, Raymond Young-Jin Cho, Raymond Young-Jin Cho, G B Ermentrout   +3 more
doaj   +1 more source

Envolvimento dos receptores NMDA e da via L-arginina-óxido nítrico-GMPc no efeito tipo-antidepressivo da guanosina [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Neurociências.A guanosina é um nucleosídeo endógeno que modula a captação de glutamato pelos astrócitos, controlando os níveis ...
Bettio, Luis Eduardo Beltrão
core  

-Methyl-D-aspartic Acid (NMDA) in the nervous system of the amphioxus -1

, 2011
Copyright information:Taken from "-Methyl-D-aspartic Acid (NMDA) in the nervous system of the amphioxus "http://www.biomedcentral.com/1471-2202/8/109BMC Neuroscience 2007;8():109-109.Published online 20 Dec 2007PMCID:PMC2241627.before purification by OPA
Salvatore D'Aniello (45524), Gabriele Ferrandino (86638), Jordi Garcia-Fernàndez (1548), George H Fisher (86636), Antimo D'Aniello (86639), Enza Topo (86637)   +5 more
core   +1 more source

Differential involvement of NMDA, AMPA/kainate, and dopamine receptors in the nucleus accumbens core in the acquisition and performance of pavlovian approach behavior [PDF]

, 2001
Stimuli paired with primary rewards can acquire emotional valence and the ability to elicit automatic, Pavlovian approach responses that have been shown to be mediated by the nucleus accumbens. The present experiment investigated the effects of infusions
Rudolf N. Cardinal, Di Ciano, Patricia, Patricia Di Ciano, Cowell, Rosemary A., Rosie A. Cowell, Barry J. Everitt, Cardinal, Rudolf N., Simon J. Little, Little, Simon J., Everitt, Barry J.   +9 more
core   +1 more source

1,2‐propanediol reformulation improves tribromoethanol safety and reveals pontine GABRA1 enrichment as a candidate mechanistic correlate of anesthesia

Animal Models and Experimental Medicine, EarlyView.
This study develops a reformulated tribromoethanol (TBE) anesthetic using 1,2‐propanediol as a solvent to overcome solvent‐related toxicity. The novel formulation demonstrates, cardiovascular stability, and survival in prolonged protocols. It provides potent, dose‐dependent anesthesia without strain or sex differences.
Xia Li, Yanming Chen, Xinyi Xiao, Guoheng Xu   +3 more
wiley   +1 more source

Generalization of NMDA-Receptor Antagonists to the Discriminative Stimulus Effects of κ-Opioid Receptor Agonists U-50,488H, but Not TRK-820 in Rats

Journal of Pharmacological Sciences, 2006
.: Generalizations of NMDA-receptor antagonists to the discriminative stimulus effects of κ-opioid receptor agonists in rats were examined. Phencyclidine, MK-801, and ketamine, noncompetitive NMDA-receptor antagonists, generalized to the discriminative ...
Tomohisa Mori, Mutsuko Nomura, Kazumi Yoshizawa, Hiroshi Nagase, Toshiko Sawaguchi, Minoru Narita, Tsutomu Suzuki   +6 more
doaj   +1 more source

Neurotransmitter‐Defined Degeneration Patterns in Sporadic and C9orf72‐Associated Amyotrophic Lateral Sclerosis: Predilection to GABAergic, Serotonergic, Opioid, Glutamatergic, Endocannabinoid, and Microglial Systems—Implications for Therapy Development

Annals of Neurology, EarlyView.
Objective Amyotrophic lateral sclerosis (ALS) has a markedly distinctive clinical and neuroradiological signature, with the preferential involvement of specific brain networks and the apparent sparing of others. The molecular underpinnings of the strikingly selective anatomical vulnerability have not been fully elucidated to date despite the potential ...
Marlene Tahedl, We Fong Siah, Jasmin Lope, Jennifer C. Hengeveld, Mark A. Doherty, Russell L. McLaughlin, Orla Hardiman, Ee Ling Tan, Alison Toomey, Jana Kleinerova, Peter Bede   +10 more
wiley   +1 more source

Acute NMDA toxicity in cultured rat cerebellar granule neurons is accompanied by autophagy induction and late onset autophagic cell death phenotype

BMC Neuroscience, 2010
Background Autophagy, an intracellular response to stress, is characterized by double membrane cytosolic vesicles called autophagosomes. Prolonged autophagy is known to result in autophagic (Type II) cell death.
Kobeissy Firas H, Zheng Wenrong, Larner Stephen F, Liu Ming C, Zhang Zhiqun, Sadasivan Shankar, Hayes Ronald L, Wang Kevin KW   +7 more
doaj   +1 more source

Synthesis and characterization of enantiopure dextromethadone analogues as NMDA receptor uncompetitive antagonists

, 2022
reservedI recettori NMDA (N-metil-D-aspartato) sono canali ionici ligando-dipendenti appartenenti alla famiglia dei recettori del glutammato, il principale neurotrasmettitore eccitatorio.
SCOPEL, FRANCESCO
core  

Anodal Transcranial Direct Current Stimulation Improves Social Behavior Alongside Neuroplastic Changes in a Tsc2+/− Rat Model of Autism Spectrum Disorder

Autism Research, EarlyView.
ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by altered synaptic connectivity and network organization, resulting in profound impairments in social communication and interaction. Transcranial direct current stimulation (tDCS) represents a promising approach to modulate maladaptive plasticity associated with ASD;
Antonia Ramme, Rebecca Winter, Natalia Jarzebska, Fatih Ögel, Marten Julian Richter, Iveta Vojtechova, Christine Winter, Tomas Petrasek, Robert Waltereit, Nadine Bernhardt   +9 more
wiley   +1 more source