Results 91 to 100 of about 22,217 (292)

AMPA, NMDA and GABAA receptor mediated network burst dynamics in cortical cultures in vitro [PDF]

Proc. Int. Works. Comp. Syst. Biol. TICSP series 8 (2011) 181-184, 2018
In this work we study the excitatory AMPA, and NMDA, and inhibitory GABAA receptor mediated dynamical changes in neuronal networks of neonatal rat cortex in vitro. Extracellular network-wide activity was recorded with 59 planar electrodes simultaneously under different pharmacological conditions.
arxiv  

Targeting the interaction of GABAB receptors with CaMKII with an interfering peptide restores receptor expression after cerebral ischemia and inhibits progressive neuronal death in mouse brain cells and slices

Brain Pathology, Volume 33, Issue 1, January 2023., 2023
There is no pharmacological treatment available to limit progressing neuronal death after cerebral ischemia. Here we show that targeting the interaction of GABAB receptors with CaMKII using a synthetic interfering peptide after an excitotoxic insult in cultured neurons or in brain slices from MCAO‐treated mice restored downregulated GABAB receptor ...
Karthik Balakrishnan, Mohammad Hleihil, Musadiq A. Bhat, Robert P. Ganley, Markus Vaas, Jan Klohs, Hanns Ulrich Zeilhofer, Dietmar Benke   +7 more
wiley   +1 more source

Enhanced synaptic long-term potentiation in the anterior cingulate cortex of adult wild mice as compared with that in laboratory mice

Molecular Brain, 2009
Activation of N-methyl D-aspartate (NMDA) receptor is important for learning, memory and persistent pain. Genetic enhancement of NMDA receptor function by overexpressing NR2B subunit significantly enhances hippocampal long-term potentiation (LTP ...
Zhao Ming-Gao, Toyoda Hiroki, Wang Yu-Kun, Zhuo Min   +3 more
doaj   +1 more source

A Mathematical model for Astrocytes mediated LTP at Single Hippocampal Synapses [PDF]

, 2011
Many contemporary studies have shown that astrocytes play a significant role in modulating both short and long form of synaptic plasticity. There are very few experimental models which elucidate the role of astrocyte over Long-term Potentiation (LTP).
arxiv   +1 more source

Mechanism of Activation in NMDA Receptors [PDF]

Biophysical Journal, 2012
The N-methyl D-aspartate receptors belong to the family of ionotropic glutamate receptors. They are obligate heteromeric receptors with two glycine binding subunits (GluN1) and two glutamate binding (GluN2A-D) subunits arranged as a dimer of dimers. We have used luminescence resonance energy transfer measurements to determine the specific arrangement ...
Vasanthi Jayaraman, Anu Rambhadran
openaire   +2 more sources

Different modes of synaptic and extrasynaptic NMDA receptor alteration in the hippocampus of P301S tau transgenic mice

Brain Pathology, Volume 33, Issue 1, January 2023., 2023
Differential alteration of synaptic versus extrasynaptic NMDARs in P301S mice. Reduced density of synaptic NMDARs in excitatory synapses in the hippocampus of P301S mice at 10 months. NMDARs at excitatory synapses established on pyramidal cell spines and interneurons are significantly reduced in the CA1 region of the hippocampus compared to age‐matched
Rocío Alfaro‐Ruiz, Carolina Aguado, Alejandro Martín‐Belmonte, Ana Esther Moreno‐Martínez, Jesús Merchán‐Rubira, Félix Hernández, Jesús Ávila, Yugo Fukazawa, Rafael Luján   +8 more
wiley   +1 more source

Conserved contributions of NMDA receptor subtypes to synaptic responses in lamina II spinal neurons across early postnatal development

Molecular Brain, 2020
NMDA receptors are heteromeric complexes that contribute to excitatory synaptic transmission and plasticity. The presence of specific variants of GluN2 subunits in these complexes enables diversity in NMDA receptor function and regulation.
Hadir Mahmoud, Newton Martin, Michael E. Hildebrand   +2 more
doaj   +1 more source

Computationally Discovered Potentiating Role of Glycans on NMDA Receptors [PDF]

arXiv, 2016
N-methyl-D-aspartate receptors (NMDARs) are glycoproteins in the brain central to learning and memory. The effects of glycosylation on the structure and dynamics of NMDARs are largely unknown. In this work, we use extensive molecular dynamics simulations of GluN1 and GluN2B ligand binding domains (LBDs) of NMDARs to investigate these effects.
arxiv  

Paradoxical signaling regulates structural plasticity in dendritic spines [PDF]

, 2016
Transient spine enlargement (3-5 min timescale) is an important event associated with the structural plasticity of dendritic spines. Many of the molecular mechanisms associated with transient spine enlargement have been identified experimentally. Here, we use a systems biology approach to construct a mathematical model of biochemical signaling and ...
arxiv   +1 more source

Detecting the Undetectable: Advances in Methods for Identifying Small Tau Aggregates in Neurodegenerative Diseases

ChemBioChem, EarlyView.
This review explores current methods for detecting and characterising small tau aggregates, which are increasingly recognised as key drivers of neurotoxicity in tauopathies. It discusses emerging techniques such as single‐molecule pull‐down (SiMPull), single‐molecule Förster resonance energy transfer (smFRET), and cryo‐electron tomography (cryo‐ET ...
Dorothea Böken, Yunzhao Wu, Ziwei Zhang, David Klenerman   +3 more
wiley   +1 more source