Results 11 to 20 of about 107,984 (270)

NMDA Receptor Modulators in the Treatment of Drug Addiction

Pharmaceuticals, 2013
Glutamate plays a pivotal role in drug addiction, and the N-methyl-D-aspartate (NMDA) glutamate receptor subtype serves as a molecular target for several drugs of abuse. In this review, we will provide an overview of NMDA receptor structure and function,
M. Foster Olive, Natali E. Nemirovsky, Seven E. Tomek, Amber L. Lacrosse   +3 more
doaj   +1 more source

A companion to the preclinical common data elements and case report forms for neuropathology studies in epilepsy research. A report of the TASK3 WG2 Neuropathology Working Group of the ILAE/AES Joint Translational Task Force

Epilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force initiated the TASK3 working group to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Eleonora Aronica, Devin K. Binder, Meinrad Drexel, Chrysanthy Ikonomidou, Shilpa D. Kadam, Guenther Sperk, Christian Steinhäuser   +6 more
wiley   +1 more source

A quantitative method to assess extrasynaptic NMDA receptor function in the protective effect of synaptic activity against neurotoxicity

BMC Neuroscience, 2008
Background Extrasynaptic NMDA receptors couple to a CREB shut-off pathway and cause cell death, whereas synaptic NMDA receptors and nuclear calcium signaling promote CREB-mediated transcription and neuronal survival.
Bading Hilmar, Dick Oliver, Bengtson C Peter   +2 more
doaj   +1 more source

A companion to the preclinical common data elements for rodent models of pediatric acquired epilepsy: A report of the TASK3‐WG1B, Pediatric and Genetic Models Working Group of the ILAE/AES Joint Translational Task Force

Epilepsia Open, EarlyView., 2022
Abstract Epilepsy syndromes during the early years of life may be attributed to an acquired insult, such as hypoxic–ischemic injury, infection, status epilepticus, or brain trauma. These conditions are frequently modeled in experimental rodents to delineate mechanisms of epileptogenesis and investigate novel therapeutic strategies.
Anna‐Maria Katsarou, Hana Kubova, Stéphane Auvin, Massimo Mantegazza, Melissa Barker‐Haliski, Aristea S. Galanopoulou, Christopher A. Reid, Bridgette D. Semple   +7 more
wiley   +1 more source

Dynamin-dependent NMDAR endocytosis during LTD and its dependence on synaptic state

BMC Neuroscience, 2005
Background The N-methyl-D-aspartate (NMDA)-type glutamate receptor expressed at excitatory glutamatergic synapses is required for learning and memory and is critical for normal brain function.
Hanson Jesse E, Selcher Joel C, Montgomery Johanna M, Madison Daniel V   +3 more
doaj   +1 more source

Hippocampal glutamate NMDA receptor loss tracks progression in Alzheimer's disease: quantitative autoradiography in postmortem human brain. [PDF]

PLoS ONE, 2013
Early Alzheimer's disease (AD) is characterized by memory loss and hippocampal atrophy with relative sparing of basal ganglia. Activation of glutamate NMDA receptors in the hippocampus is an important step in memory formation.
Efrat Kravitz, Inna Gaisler-Salomon, Anat Biegon   +2 more
doaj   +1 more source

GluN2B-NMDAR subunit contribution on synaptic plasticity: A phenomenological model for CA3-CA1 synapses

Frontiers in Synaptic Neuroscience, 2023
Synaptic plasticity is believed to be a key mechanism underlying learning and memory. We developed a phenomenological N-methyl-D-aspartate (NMDA) receptor-based voltage-dependent synaptic plasticity model for synaptic modifications at hippocampal CA3-CA1
Justinas J. Dainauskas, Justinas J. Dainauskas, Hélène Marie, Michele Migliore, Ausra Saudargiene   +4 more
doaj   +1 more source

High- and low-conductance NMDA receptors are present in layer 4 spiny stellate and layer 2/3 pyramidal neurons of mouse barrel cortex [PDF]

Physiological Reports, 30th Dec. 2016, Vol. 4 no. e13051, 2016
NMDA receptors are ion channels activated by the neurotransmitter glutamate in the mammalian brain and are important in synaptic function and plasticity, but are also found in extrasynaptic locations and influence neuronal excitability. There are different NMDA receptor subtypes which differ in their single-channel conductance.
arxiv   +1 more source

Dissecting the contribution of individual receptor subunits to the enhancement of N-methyl-D-aspartate currents by dopamine D1 receptor activation in striatum

Frontiers in Systems Neuroscience, 2011
Dopamine, via activation of D1 receptors, enhances N-methyl-D-aspartate (NMDA) receptor-mediated responses in striatal medium-sized spiny neurons. However, the role of specific NMDA receptor subunits in this enhancement remains unknown.
Emily L Jocoy, Véronique M André, Damian M Cummings, Shilpa P Rao, Nanping eWu, Amy J Ramsey, Marc G Caron, Carlos eCepeda, Michael S Levine   +8 more
doaj   +1 more source

mGluR5 positive modulators both potentiate activation and restore inhibition in NMDA receptors by PKC dependent pathway

Journal of Biomedical Science, 2011
Background In order to understand the interaction between the metabotropic glutamate subtype 5 (mGluR5) and N-methyl-D-aspartate (NMDA) receptors, the influence of mGluR5 positive modulators in the inhibition of NMDA receptors by the noncompetitive ...
Liao Pei-Fei, Chen Hwei-Hsien, Chan Ming-Huan   +2 more
doaj   +1 more source