Results 11 to 20 of about 2,517,861 (360)

NMDA Receptor Modulators in the Treatment of Drug Addiction

Pharmaceuticals, 2013
Glutamate plays a pivotal role in drug addiction, and the N-methyl-D-aspartate (NMDA) glutamate receptor subtype serves as a molecular target for several drugs of abuse. In this review, we will provide an overview of NMDA receptor structure and function,
M. Foster Olive, Natali E. Nemirovsky, Seven E. Tomek, Amber L. Lacrosse   +3 more
doaj   +1 more source

N-Methyl-D-aspartate (NMDA) and cannabinoid CB2 receptors form functional complexes in cells of the central nervous system: insights into the therapeutic potential of neuronal and microglial NMDA receptors

Alzheimer’s Research & Therapy, 2021
Background The cannabinoid CB2 receptor (CB2R), which is a target to afford neuroprotection, and N-methyl-D-aspartate (NMDA) ionotropic glutamate receptors, which are key in mediating excitatory neurotransmission, are expressed in both neurons and glia ...
Rafael Rivas-Santisteban, Alejandro Lillo, Jaume Lillo, Joan-Biel Rebassa, Joan S. Contestí, Carlos A. Saura, Rafael Franco, Gemma Navarro   +7 more
doaj   +1 more source

NMDA Receptor Blockade at Rest Triggers Rapid Behavioural Antidepressant Responses

Nature, 2011
Clinical studies consistently demonstrate that a single sub-psychomimetic dose of ketamine, an ionotropic glutamatergic NMDAR (N-methyl-D-aspartate receptor) antagonist, produces fast-acting antidepressant responses in patients suffering from major ...
Anita E. Autry, M. Adachi, E. Nosyreva, E. Na, Maarten F. Los, Peng Cheng, E. Kavalali, L. Monteggia   +7 more
semanticscholar   +1 more source

A quantitative method to assess extrasynaptic NMDA receptor function in the protective effect of synaptic activity against neurotoxicity

BMC Neuroscience, 2008
Background Extrasynaptic NMDA receptors couple to a CREB shut-off pathway and cause cell death, whereas synaptic NMDA receptors and nuclear calcium signaling promote CREB-mediated transcription and neuronal survival.
Bading Hilmar, Dick Oliver, Bengtson C Peter   +2 more
doaj   +1 more source

GluN2B-NMDAR subunit contribution on synaptic plasticity: A phenomenological model for CA3-CA1 synapses

Frontiers in Synaptic Neuroscience, 2023
Synaptic plasticity is believed to be a key mechanism underlying learning and memory. We developed a phenomenological N-methyl-D-aspartate (NMDA) receptor-based voltage-dependent synaptic plasticity model for synaptic modifications at hippocampal CA3-CA1
Justinas J. Dainauskas, Justinas J. Dainauskas, Hélène Marie, Michele Migliore, Ausra Saudargiene   +4 more
doaj   +1 more source

Dynamin-dependent NMDAR endocytosis during LTD and its dependence on synaptic state

BMC Neuroscience, 2005
Background The N-methyl-D-aspartate (NMDA)-type glutamate receptor expressed at excitatory glutamatergic synapses is required for learning and memory and is critical for normal brain function.
Hanson Jesse E, Selcher Joel C, Montgomery Johanna M, Madison Daniel V   +3 more
doaj   +1 more source

Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex

Journal of Neuroscience, 1997
Subanesthetic doses of ketamine, a noncompetitive NMDA receptor antagonist, impair prefrontal cortex (PFC) function in the rat and produce symptoms in humans similar to those observed in schizophrenia and dissociative states, including impaired ...
B. Moghaddam, Barbara W. Adams, A. Verma, D. Daly   +3 more
semanticscholar   +1 more source

Chimeric glutamate receptor subunits reveal the transmembrane domain is sufficient for NMDA receptor pore properties but some positive allosteric modulators require additional domains [PDF]

, 2016
NMDA receptors are ligand-gated ion channels that underlie transmission at excitatory synapses and play an important role in regulating synaptic strength and stability.
Huettner, Jmaes E, Lopez, Melany N, Wilding, Timothy J   +2 more
core   +2 more sources

Dissecting the contribution of individual receptor subunits to the enhancement of N-methyl-D-aspartate currents by dopamine D1 receptor activation in striatum

Frontiers in Systems Neuroscience, 2011
Dopamine, via activation of D1 receptors, enhances N-methyl-D-aspartate (NMDA) receptor-mediated responses in striatal medium-sized spiny neurons. However, the role of specific NMDA receptor subunits in this enhancement remains unknown.
Emily L Jocoy, Véronique M André, Damian M Cummings, Shilpa P Rao, Nanping eWu, Amy J Ramsey, Marc G Caron, Carlos eCepeda, Michael S Levine   +8 more
doaj   +1 more source

Hippocampal glutamate NMDA receptor loss tracks progression in Alzheimer's disease: quantitative autoradiography in postmortem human brain. [PDF]

PLoS ONE, 2013
Early Alzheimer's disease (AD) is characterized by memory loss and hippocampal atrophy with relative sparing of basal ganglia. Activation of glutamate NMDA receptors in the hippocampus is an important step in memory formation.
Efrat Kravitz, Inna Gaisler-Salomon, Anat Biegon   +2 more
doaj   +1 more source