Results 201 to 210 of about 203,682 (360)

A kainic acid-induced status epilepticus model of epileptogenesis in the C57BL/6J mouse. Interventions targeting nitric oxide and NMDA receptor-mediated pathophysiology

, 2013
Edward Beamer
openalex   +1 more source

Effect of peri‐operative pharmacological interventions on postoperative delirium in patients having cardiac surgery: a systematic review and Bayesian network meta‐analysis

Anaesthesia, EarlyView.
Summary Introduction Postoperative delirium is a common complication following cardiac surgery. Despite its known impact on patient outcomes, effective preventative strategies remain elusive. We aimed to perform a comprehensive Bayesian network meta‐analysis of randomised controlled trials assessing the effect of pharmacological interventions on the ...
Ivo Queiroz, Lucas M. Barbosa, Mariano Gallo Ruelas, Beatriz Araújo, Maria L. R. Defante, Arthur H. Tavares, Cynthia Florencio de Mesquita, Tulio Pimentel, Beatriz Ximenes Mendes, Iuri Ferreira Felix, André Rivera, Rafael Oliva Morgado Ferreira, Helen M. de Oliveira, Bruno B. Righetto, Nathan J. Smischney, Guangyu Tong, Daqing Ma   +16 more
wiley   +1 more source

Enhancement of hippocampal interneuron excitability by NMDA receptor positive allosteric modulation. [PDF]

J Physiol
Xing H, Banke TG, Zhang L, Yu K, Camp CR, Fritzemeier RG, Akins NS, Paladugu S, Arcoria PJ, Brady BR, Prikhodko O, Kennedy MJ, Liotta DC, Yuan H, Traynelis SF.   +14 more
europepmc   +1 more source

NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation

, 2009
Angela Brennan, Sang Won Suh, Seok Joon Won, Purnima Narasimhan, Tiina M. Kauppinen, Hokyou Lee, Ylva Edling, Pak H. Chan, Raymond A. Swanson   +8 more
openalex   +1 more source

Reflections on Consciousness in Intensive Care

Acta Paediatrica, EarlyView.
ABSTRACT Evaluating consciousness in intensive care is pivotal to relieving suffering with analgesic or sedative drugs and in prognosis and diagnoses. The usual clinical perspective is to equate consciousness with responsiveness, assuming functional motor responses and sympathetic activity of the patient. Clinical diagnoses of coma may be wrong in more
Michael Broomé, Tiit Mathiesen
wiley   +1 more source

Cryo-EM snapshots of NMDA receptor activation illuminate sequential rearrangements. [PDF]

Sci Adv
Abbott JA, Kim J, Liu B, Popescu GK, Gouaux E, Jalali-Yazdi F.   +5 more
europepmc   +1 more source

GluN2D Subunit-Containing NMDA Receptors Control Tissue Plasminogen Activator-Mediated Spatial Memory [PDF]

, 2012
Pauline Obiang, Richard Macrez, Amandine Jullienne, Thomas Bertrand, Flavie Lesept, Carine Ali, Eric Maubert, Denis Vivien, Véronique Agin   +8 more
openalex   +1 more source

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

British Journal of Pharmacology, EarlyView.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander, Dasha Anderson, Luke Baxter, Matthew Claydon, James Rucker, Emma S. J. Robinson   +5 more
wiley   +1 more source

Psychedelics, entactogens and psychoplastogens for depression and related disorders

British Journal of Pharmacology, EarlyView.
Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N,N‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g.
Daniel Hoyer
wiley   +1 more source

Nanobody therapy rescues behavioural deficits of NMDA receptor hypofunction. [PDF]

Nature
Oosterlaken M, Rogliardo A, Lipina T, Lafon PA, Tsitokana ME, Keck M, Cahuzac H, Prieu-Sérandon P, Diem S, Derieux C, Camberlin C, Lafont C, Meyer D, Chames P, Vandermoere F, Marin P, Prézeau L, Servent D, Salahpour A, Ramsey AJ, Bécamel C, Pin JP, Kniazeff J, Rondard P.   +23 more
europepmc   +1 more source