Results 201 to 210 of about 186,082 (377)

Molecular pharmacological characterisation of recombinant and native NR2B- and NR3B- containing NMDA receptors [PDF]

open access: yes, 2008
NMDA receptors are ionotropic, glutamate receptors which mediate fast excitatory transmissions within the central nervous system. They form tetrameric or pentameric heterologous complexes from seven NMDA receptor subunits NRl, NR2A-D and NR3A-B which ...
Chaffey, Heather Emily
core  

Molecular and cellular mechanisms underlying gyrate atrophy: Why is the retina primarily affected?

open access: yesActa Ophthalmologica, EarlyView.
Abstract Gyrate atrophy of the choroid and retina (GACR; OMIM #258870) is a rare early‐onset autosomal recessive disorder, caused by bi‐allelic pathogenic variants in the gene coding for ornithine aminotransferase (OAT) resulting in hyperornithinaemia.
Mark J. N. Buijs   +12 more
wiley   +1 more source

Actions of ketamine, phencyclidine and MK‐801 on NMDA receptor currents in cultured mouse hippocampal neurones.

open access: green, 1991
John F. MacDonald   +7 more
openalex   +2 more sources

Protein chemical characterization and immunocytochemical localization of the NMDA receptor subunit NMDA R1.

open access: hybrid, 1993
Nils Brose   +4 more
openalex   +1 more source

Molecular pharmacology of a Novel NR2B-selective NMDA Receptor Antagonist [PDF]

open access: yes, 2006
The NMDA receptor is a heteromeric ligand-gated ion channel in the central nervous system (CNS). There are three families of NMDA receptor subunits with various combinations of NRl, NR2A-D and NR3A֊B subunits producing unique receptors with distinctive ...
Bradford, Andrea Marie
core  

Isolated Choreic Manifestations Indicative of Anti‐Amphiphysin Antibody‐Related Encephalitis in Breast Cancer

open access: yes
Movement Disorders, EarlyView.
Stela Dodaj   +8 more
wiley   +1 more source

ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system

open access: yesBritish Journal of Pharmacology, EarlyView.
G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important
Necla Birgül Iyison   +15 more
wiley   +1 more source

Up-regulation of GluN2A-containing NMDA receptor protects cultured cortical neuron cells from oxidative stress

open access: yesHeliyon, 2018
Neuronal excitotoxicity induced by spreading depolarization occurs during multiple brain diseases. The subsequent extensive releasing of neuronal transmitter glutamate results in over activation of the ionic glutamate receptors and then triggers neuronal
Jia Zhu   +5 more
doaj  

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

open access: yesBritish Journal of Pharmacology, EarlyView.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander   +5 more
wiley   +1 more source

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