Results 211 to 220 of about 186,082 (377)

Kindling induces the long-lasting expression of a novel population of NMDA receptors in hippocampal region CA3 [PDF]

, 1994
J.E. Kraus, GC Yeh, DW Bonhaus, J. Victor Nadler, JO McNamara   +4 more
openalex   +1 more source

Sex differences in the vasoactive effect of transient receptor potential channels: TRPM3 as a new therapeutic target for (neuro)vascular disorders

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Sex‐dependent vascular effects of transient receptor potential (TRP) channels and sex dimorphism in migraine are not yet fully characterized. We investigated the differential vasoactive effects of TRP ankyrin 1 (TRPA1), TRP melastatin 3 (TRPM3) and TRP vanilloid 1 (TRPV1) channels, their pharmacological mechanism(s), and
Eduardo Rivera‐Mancilla, Usha M. Musterd‐Bhaggoe, Dennis Schutter, Antoon van den Bogaerdt, Arnaud J. P. E. Vincent, Carlos M. Villalón, Alexander H. J. Danser, Antoinette MaassenVanDenBrink   +7 more
wiley   +1 more source

Characterization of the Cerebroprotective Efficacy of the Competitive NMDA Receptor Antagonist CGP40116 in a Rat Model of Focal Cerebral Ischemia: An in vivo Magnetic Resonance Imaging Study

, 1993
Dirk Sauer, Peter R. Allegrini, Alexandra Cosenti, A. Pataki, Hugo Amacker, Graham E. Fagg   +5 more
openalex   +1 more source

(2R,6R)‐hydroxynorketamine prevents opioid abstinence‐related negative affect and stress‐induced reinstatement in mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Opioid use disorder (OUD) is a pressing public health concern marked by frequent relapse during periods of abstinence, perpetuated by negative affective states. Classical antidepressants or the currently prescribed opioid pharmacotherapies have limited efficacy to reverse the negative affect or prevent relapse ...
Andria Michael, Anna Onisiforou, Polymnia Georgiou, Morfeas Koumas, Chris Powels, Elmar Mammadov, Andrea N. Georgiou, Panos Zanos   +7 more
wiley   +1 more source

Aetiopathogenesis of infantile epileptic spasms syndrome and mechanisms of action of adrenocorticotrophin hormone/corticosteroids in children: A scoping review

Developmental Medicine &Child Neurology, EarlyView.
Why does infantile epileptic spasms syndrome (IESS) occur with a variety of underlying conditions and why does it respond to adrenocorticotrophin hormone (ACTH)/corticosteroids? Our scoping review summarizes five hypotheses from the literature: gene/epigenetic regulation, stress/HPA axis activation, neuroinflammation/immune function, altered neuronal ...
Emily A. Innes, Velda X. Han, Shrujna Patel, Michelle A. Farrar, Deepak Gill, Shekeeb S. Mohammad, Russell C. Dale   +6 more
wiley   +1 more source

Genetic testing in cerebral palsy with clinical and neuroimaging variables

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To optimize genetic testing in children with cerebral palsy (CP) by using clinical and magnetic resonance imaging (MRI) variables. Method In this mixed methods study, we surveyed current approaches to genetic testing by Australian clinicians involved in the diagnosis of CP.
Esther M. Tantsis, Shekeeb S. Mohammad, Simon P. Paget, Yisselle I. Virella‐Perez, Velda X. Han, Dianah Hadi, Chaya Goldman, Michelle A. Farrar, Michael Fahey, Russell C. Dale, the GENE‐CP study group, Kristine Alba‐Concepcion, David J Amor, Tajul Arifin Tajudin, Nadia Badawi, Elizabeth Barnes, Bruce Bennetts, Hilla Ben Pazi, Darius Ebrahimi‐Fakhari, Darcy Fehlings, Donna M Ferriero, Jennifer Friedman, Jozef Gecz, Gladys Ho, Sachin Gupta, Rod W Hunt, Kavitha Kothur, Michael Kruer, Manju A Kurian, Maria Kyriagis, Wang Tso Lee, Sarah McIntyre, Aurélie Méneret, Jonathan W Mink, Catherine Morgan, Angela Morrow, Nardo Nardocci, Emanuela Pagliano, Elizabeth E. Palmer, Toni S Pearson, Belén Pérez‐Dueñas, Emmanuel Roze, Michael Shevell, Anna te Velde, Mary‐Clare Waugh, Michèl A Willemsen, Yana A Wilson   +46 more
wiley   +1 more source

MK-801 blocked the functional NMDA receptors in identified cerebellar neurons

, 1990
Michisuke Yuzaki, Yoshihisa Kudo, Kyoko Akita, Atsushi Miyawaki, Katsuhiko Mikoshiba   +4 more
openalex   +1 more source

A review of the putative antiseizure and antiepileptogenic mechanisms of action for soticlestat

Epilepsia, EarlyView.
Abstract Soticlestat (TAK‐935) is a potent and selective inhibitor of cholesterol 24‐hydroxylase (CYP46A1), an enzyme primarily expressed in the brain that catabolizes cholesterol to 24S‐hydroxycholesterol (24HC). In the ELEKTRA phase II clinical trial, soticlestat reduced seizure frequency in patients with developmental and epileptic encephalopathies,
Shinichi Kondo, Venkatesha Murthy, Mahnaz Asgharnejad, Arturo Benitez, Kosuke Nakashima, Nicole Hawkins, H. Steve White   +6 more
wiley   +1 more source

Long-term D1-dopamine receptor sensitization in neonatal 6-OHDA-lesioned rats is blocked by an NMDA antagonist

, 1990
Hugh E. Criswell, Robert A. Mueller, George R. Breese   +2 more
openalex   +2 more sources

The Essential Role of Hippocampal CA1 NMDA Receptor–Dependent Synaptic Plasticity in Spatial Memory [PDF]

, 1996
Joe Z. Tsien, Patricio T. Huerta, Susumu Tonegawa   +2 more
openalex   +1 more source