Results 71 to 80 of about 22,217 (292)
Two-trace model for spike-timing-dependent synaptic plasticity [PDF]
Neural Computation 2015, 27(3), 672-698, 2014 We present an effective model for timing-dependent synaptic plasticity (STDP) in terms of two interacting traces, corresponding to the fraction of activated NMDA receptors and the Ca2+ concentration in the dendritic spine of the postsynaptic neuron.
arxiv +1 more source
Advanced Science, EarlyView.The anterior piriform cortex (APC) exhibits distinct neural firings and calcium transients in response to familiar and novel mice, with a more robust response to the novel one. Selectively inhibiting APC pyramidal neurons disrupt social novelty recognition without impairing basic odor discrimination.
Jingwei Zhou +10 more
wiley +1 more source
Integrated Regulation of Signal Coding and Plasticity by NMDA Receptors at a Central Synapse
Neural Plasticity, 1998 The role of NMDA and non-NMDA glutamate receptors in long-term potentiation has been intensely investigated, yet recent evidence on the dynamics of synaptic depolarization suggests that the original view should be extended.
Egidio D'Angelo, Paola Rossi
doaj +1 more source
PLoS ONE, 2021 LRFN2 encodes a synaptic adhesion-like molecule that physically interacts with N-methyl-D-aspartate (NMDA) receptor 1 and its scaffold proteins. Previous studies in humans and mice have demonstrated its genetic association with neurodevelopmental ...
Ryuta Maekawa +3 more
doaj +1 more source
Modulating synaptic NMDA receptors [PDF]
Neuropharmacology, 2017 Recent structural information on ligand-gated glutamate receptors and newly-discovered clinical uses for NMDA receptor antagonists has renewed interest in understanding the mechanisms of drug action at these receptors. Although the voltage-dependence and calcium permeability of NMDA receptors are well-studied, the mechanisms affecting the time course ...
Gary L. Westbrook, Kenneth R. Tovar
openaire +3 more sources
Cell‐Type Specific Circuits in the Mammillary Body for Place and Object Recognition Memory
Advanced Science, EarlyView.Li et al. defined two novel glutamatergic neuronal subtypes in the medial mammillary nucleus, pars lateralis‐located parvalbumin (PV) neurons, and basalis‐located Drd2 neurons. PV and Drd2 neurons differ in their electrophysiological properties encoded by Kcnn4 and Cacna1h, and selectively modulate place and object recognition memory by two distinct ...
Lanfang Li +11 more
wiley +1 more source
Neuropsychopharmacology Reports, Volume 42, Issue 4, Page 421-429, December 2022., 2022 Abstract Background Depression is a common disorder that affects patients' quality of life and incurs health system costs. Due to the resistance to treat depression, better understanding of neurophysiology was considered; one of the implications is the glutamatergic system.
Ahmad Shamabadi
wiley +1 more source
Journal of Biomedical Science, 2012 Background Acute exposure of ethanol (alcohol) inhibits NMDA receptor function. Our previous study showed that acute ethanol inhibited the pressor responses induced by NMDA applied intrathecally; however, prolonged ethanol exposure may increase the ...
Keng Nien-Tzu +4 more
doaj +1 more source
PLoS Computational Biology, 2021 NMDA receptors promote repolarization in pancreatic beta cells and thereby reduce glucose-stimulated insulin secretion. Therefore, NMDA receptors are a potential therapeutic target for diabetes.
Marko Šterk +6 more
doaj +1 more source
A single psychotomimetic dose of ketamine decreases thalamocortical spindles and delta oscillations in the sedated rat [PDF]
arXiv, 2020 Background: In patients with psychotic disorders, sleep spindles are reduced, supporting the hypothesis that the thalamus and glutamate receptors play a crucial etio-pathophysiological role, whose underlying mechanisms remain unknown. We hypothesized that a reduced function of NMDA receptors is involved in the spindle deficit observed in schizophrenia.
arxiv