Results 71 to 80 of about 197,779 (358)
Advanced Science, EarlyView.This study demonstrates that prolonged rhythmic 40 Hz light flicker enhances spatial learning by stimulating PV interneuron‐dependent neurogenesis. The light flicker selectively activates PV interneurons, which enhances GABAergic support for the integration of immature neurons in the adult dentate gyrus.
Hai Yan +16 more
wiley +1 more source
Integrated Regulation of Signal Coding and Plasticity by NMDA Receptors at a Central Synapse
Neural Plasticity, 1998 The role of NMDA and non-NMDA glutamate receptors in long-term potentiation has been intensely investigated, yet recent evidence on the dynamics of synaptic depolarization suggests that the original view should be extended.
Egidio D'Angelo, Paola Rossi
doaj +1 more source
NMDA-receptor activation but not ion flux is required for amyloid-beta induced synaptic depression. [PDF]
PLoS ONE, 2013 Alzheimer disease is characterized by a gradual decrease of synaptic function and, ultimately, by neuronal loss. There is considerable evidence supporting the involvement of oligomeric amyloid-beta (Aβ) in the etiology of Alzheimer's disease ...
Albert Tamburri +4 more
doaj +1 more source
Advanced Brain‐on‐a‐Chip for Wetware Computing: A Review
Advanced Science, EarlyView.Exploring Low‐Power, Beyond‐Silicon‐Computing Bio‐Computing: Brain‐on‐a‐Chip Technology. This article reviews the applications of Brain‐on‐a‐Chip in Wetware Computing, including in vitro‐cultured brain organoids, microelectrode arrays, electrophysiological interfaces, and microfluidic platforms, as well as data processing methods. It also looks forward
Shangchen Li +11 more
wiley +1 more source
Journal of Pharmacological Sciences, 2005 N-Methyl-D-aspartate (NMDA) receptors are a principal subtype of excitatory ligand-gated ion channels with crucial roles in a variety of physiological and pathological processes in the mammalian central nervous system (CNS).
Noritaka Nakamichi, Yukio Yoneda
doaj +1 more source
Synaptic Function in Memristor Devices for Neuromorphic Circuit Applications
Advanced Electronic Materials, EarlyView.Discover how neuromorphic devices mimic brain‐like learning: this article explores how ionic and electronic conduction processes enable artificial synapses to adapt across time scales. Uncover the essential ingredients—state‐variable dynamics, rectification, and memory—and how they can be probed through nonlinear diagnostics to engineer smarter, more ...
Juan Bisquert +3 more
wiley +1 more source
Molecular Brain, 2009 Activation of N-methyl D-aspartate (NMDA) receptor is important for learning, memory and persistent pain. Genetic enhancement of NMDA receptor function by overexpressing NR2B subunit significantly enhances hippocampal long-term potentiation (LTP ...
Zhao Ming-Gao +3 more
doaj +1 more source
Activation of NMDA receptors in brain endothelial cells increases transcellular permeability
Fluids and Barriers of the CNS, 2022 Neurovascular coupling is a precise mechanism that induces increased blood flow to activated brain regions, thereby providing oxygen and glucose.
Kyu-Sung Kim +4 more
doaj +1 more source
Cell biological mechanisms of activity-dependent synapse to nucleus translocation of CRTC1 in neurons. [PDF]
, 2015 Previous studies have revealed a critical role for CREB-regulated transcriptional coactivator (CRTC1) in regulating neuronal gene expression during learning and memory. CRTC1 localizes to synapses but undergoes activity-dependent nuclear translocation to
Ch'ng, Toh Hean +5 more
core +1 more source
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.ABSTRACT The missense SNP NC_000004.12:g.102267552C>T (also known as SLC39A8.p.(Ala391Thr), rs13107325) in SLC39A8 encodes a zinc transporter. This SNP has been linked to schizophrenia and is the likely causal variant for one of the genome‐wide association loci associated with the disorder. Using regression analyses, we tested whether the schizophrenia‐
Sophie E. Smart +12 more
wiley +1 more source