Results 81 to 90 of about 107,984 (270)
Molecular Brain, 2020 NMDA receptors are heteromeric complexes that contribute to excitatory synaptic transmission and plasticity. The presence of specific variants of GluN2 subunits in these complexes enables diversity in NMDA receptor function and regulation.
Hadir Mahmoud +2 more
doaj +1 more source
Journal of Physiological SciencesThe balance of activity between glutamatergic and GABAergic networks is particularly important for oscillatory neural activities in the brain. Here, we investigated the roles of GABAB receptors in network oscillation in the oral somatosensory cortex (OSC)
Hiroyuki Kanayama +4 more
doaj +1 more source
Inherited metabolic epilepsies–established diseases, new approaches
Epilepsia Open, EarlyView.Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley +1 more source
Frontiers in Neurology, 2019 Anti-NMDA receptor encephalitis is a rare and often therapy-responsive autoimmune disease that usually affects young adults and causes neuropsychiatric symptoms.
Franz Felix Konen +7 more
doaj +1 more source
Biased Random-Walk Learning: A Neurobiological Correlate to Trial-and-Error [PDF]
arXiv, 1993 Neural network models offer a theoretical testbed for the study of learning at the cellular level. The only experimentally verified learning rule, Hebb's rule, is extremely limited in its ability to train networks to perform complex tasks. An identified cellular mechanism responsible for Hebbian-type long-term potentiation, the NMDA receptor, is highly
arxiv
Precision therapies for genetic epilepsies in 2025: Promises and pitfalls
Epilepsia Open, EarlyView.Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang +3 more
wiley +1 more source
Instantons in the working memory: implications for schizophrenia [PDF]
arXiv, 1999 The influence of the synaptic channel properties on the stability of delayed activity maintained by recurrent neural network is studied. The duration of excitatory post-synaptic current (EPSC) is shown to be essential for the global stability of the delayed response.
arxiv
Astroglial CB1 Reveal Sex‐Specific Synaptic Effects of Amphetamine
Glia, EarlyView.Astroglial CB1R mediates long‐term synaptic plasticity (LTD) in the Nucleus accumbens. Amphetamine saturates adenosine receptors and blocks LTD in males, but not females. Locomotor effects of amphetamine require astroglial CB1R in males, but not in females.
Yamuna Mariani +15 more
wiley +1 more source
Glia, EarlyView.Cell culture studies show disrupted astrocyte physiology in the leukodystrophy MLC. Are intact astrocytes similarly affected? This study on astrocytes in MLC mouse brain slices confirms and extends in vitro studies on altered astrocyte physiology. ABSTRACT Electrical signaling, driven by ion fluxes between intra‐ and extracellular compartments, is ...
Sven Kerst +5 more
wiley +1 more source
A neuroeconomic theory of bidirectional synaptic plasticity and addiction [PDF]
arXiv, 2011 Neuronal mechanisms underlying addiction have been attracting attention in neurobiology, economics, neuropsychiatry, and neuroeconomics. This paper proposes a possible link between economic theory of addiction (Becker and Murphy, 1988) and neurobiological theory of bidirectional synaptic plasticity (Bienenstock, Cooper, Munro, 1982) based on recent ...
arxiv