Results 81 to 90 of about 22,217 (292)
Application and Assessment of Deep Learning for the Generation of Potential NMDA Receptor Antagonists [PDF]
, 2020 Uncompetitive antagonists of the N-methyl D-aspartate receptor (NMDAR) have demonstrated therapeutic benefit in the treatment of neurological diseases such as Parkinson's and Alzheimer's, but some also cause dissociative effects that have led to the synthesis of illicit drugs.
arxiv +1 more source
An Electrolyte‐Gated InGaZnO Phototransistor that Emulates Visual Experience‐Dependent Plasticity
Advanced Electronic Materials, EarlyView.By utilizing the light‐history‐dependent property of the IGZO electrolyte‐gated transistor, Bienenstock‐Cooper‐Munro (BCM) learning rule is successfully emulated. Moreover, the BCM learning rule enables a variety of bionic vision functions including image edge detection and associative memory, which offers a promising route for simulating high‐order ...
Zheng Wang +11 more
wiley +1 more source
Anti-NMDA Receptor Encephalitis or Psychiatric disorder?
European Psychiatry, 2022 Introduction Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis commonly begins with a prodromal phase characterized by flu-like symptoms, subsequently the patients experience a rapid deterioration with psychiatric symptoms that may include anxiety,
B. Freitas +4 more
doaj +1 more source
Advanced Intelligent Systems, EarlyView.This article describes the spiking implementation of an arithmetic logic unit, the fundamental basis of which lies in the use of spiking logic gates. An extensive series of experiments validates the implemented designs on SpiNNaker and Dynap‐SE. This work takes a first step in the implementation of a spiking central processing unit.
Alvaro Ayuso‐Martinez +5 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.Systematic process of collecting studies based on PRISMA. Abstract Background Due to the widespread use of cell phone devices today, numerous research studies have focused on the adverse effects of electromagnetic radiation on human neuropsychological and reproductive systems.
Mohammad Amiri +2 more
wiley +1 more source
Neurodegeneration in multiple sclerosis
WIREs Mechanisms of Disease, Volume 15, Issue 1, January/February 2023., 2023 Chronic demyelination results in impaired axon metabolism and function, ultimately leading to progressive neurological decline. Neuroprotective strategies aim to protect axons from inflammatory‐mediated destruction, thereby improving axonal integrity and clinical disability (Image created in BioRender.com).
Gabrielle M. Mey +2 more
wiley +1 more source
Anti-NMDA-receptor antibody encephalitis in infants
Epilepsy and Behavior Case Reports, 2015 Purpose: Anti-N-methyl-d-aspartate (NMDA) receptor antibody encephalitis is an autoimmune disorder manifesting subacutely with prominent aberrant movements and psychiatric symptoms.
Amr A. Matoq +5 more
doaj +1 more source
The Case of a 67‐Year‐Old Man With Memory Difficulties and Altered Sleep
Annals of Clinical and Translational Neurology, EarlyView.
Wesley Peng, Borna Bonakdarpour
wiley +1 more source
Purine Metabolism and Dystonia: Perspectives of a Long‐Promised Relationship
Annals of Neurology, EarlyView.Purine pool imbalance in purine metabolism disorders, such as Lesch–Nyhan disease, intersects with dystonia pathogenesis. The recent discovery of gain‐of‐function IMPDH2 pathogenic variants in patients with prominent dystonic manifestations provides new insights into the link between dystonia and purinergic system defects.
Ugo Sorrentino +4 more
wiley +1 more source
An Analytically Solvable Model of Firing Rate Heterogeneity in Balanced State Networks [PDF]
arXiv, 2023 Distributions of neuronal activity within cortical circuits are often found to display highly skewed shapes with many neurons emitting action potentials at low or vanishing rates, while some are active at high rates. Theoretical studies were able to reproduce such distributions, but come with a lack of mathematical tractability, preventing a deeper ...
arxiv