Results 91 to 100 of about 43,559 (247)

Investigations in animal models of anti-NMDAR encephalitis [PDF]

, 2021
Programa de Doctorat en Biomedicina / Tesi realitzada a l'Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) i a l'Hospital Clínic[eng] BACKGROUND: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a neuronal antibody-mediated ...
García Serra, Anna
core   +2 more sources

A Specific Role of Hippocampal NMDA Receptors and Arc Protein in Rapid Encoding of Novel Environmental Representations and a More General Long-Term Consolidation Function

Frontiers in Behavioral Neuroscience, 2019
Activation of the NMDA receptor (NMDAR) has been proposed to be a key event responsible for the structural changes that occur in neurons during learning and memory formation.
Cameron M. Bye, Robert J. McDonald
doaj   +1 more source

Neuroprotective effects of ursodeoxycholic acid in Parkinson's disease and Alzheimer's disease

Neuroprotection, EarlyView.
In Parkinson's disease (PD) and Alzheimer's disease (AD), various shared pathological mechanisms exist. UDCA has been shown to exert neuroprotective effects in preclinical and clinical studies. Such effects include the mitigation of neuroinflammation as well as rescue effects on mitochondrial dysfunction, oxidative stress, impaired autophagy, and ...
Ashley En Yi Chong, Andrew Octavian Sasmita, Rhun Yian Koh, Anna Pick Kiong Ling   +3 more
wiley   +1 more source

Proteomic Profiling of Primary Hippocampal Neurons Reveals Noncanonical GFAP Expression and Metabolic Adaptations in Glia‐Free Culture

PROTEOMICS, EarlyView.
ABSTRACT Despite their widespread use as a research model, a comprehensive, quantitative proteomic profile of the cultured hippocampal neurons has remained unexplored. Here, we provide the first global proteomic characterization of primary murine hippocampal neurons cultured for 14 days under near‐physiological glucose conditions (2.5 mM).
Dominika Drulis‐Fajdasz, Kinga Gostomska‐Pampuch, Natalia Pudełko‐Malik, Mariusz Fleszar, Agnieszka Gizak, Jacek R. Wiśniewski, Dariusz Rakus   +6 more
wiley   +1 more source

Frequency, characteristics, and immunological accompaniments of ataxia in anti-NMDAR antibody-associated encephalitis

Frontiers in Immunology
IntroductionVery rarely, adult NMDAR antibody-associated encephalitis (NMDAR-E) leads to persistent cerebellar atrophy and ataxia. Transient cerebellar ataxia is common in pediatric NMDAR-E. Immune-mediated cerebellar ataxia may be associated with myelin
Sarah Jesse, Marie Riemann, Hauke Schneider, Marius Ringelstein, Marius Ringelstein, Nico Melzer, Niklas Vogel, Lena Kristina Pfeffer, Manuel A. Friese, Kurt-Wolfram Sühs, Dominica Hudasch, Philipp Schwenkenbecher, Albrecht Günther, Christian Geis, Jonathan Wickel, Martin Lesser, Annika Kather, Frank Leypoldt, Frank Leypoldt, Justina Dargvainiene, Robert Markewitz, Klaus-Peter Wandinger, Franziska S. Thaler, Franziska S. Thaler, Joseph Kuchling, Katharina Wurdack, Lidia Sabater, Lidia Sabater, Carsten Finke, Jan Lewerenz   +29 more
doaj   +1 more source

Diving Deeper Into Mechanisms of Acrylamide‐Induced Toxicity: RNA Sequencing Reveals Transcriptomic Alteration and Retrotransposon Expression in Drosophila melanogaster

Environmental Toxicology, EarlyView.
ABSTRACT Given the inevitability of human and animal exposure to acrylamide, there is increasing concern regarding its potential health risks. While a number of molecular mechanisms have been proposed, the complexity of acrylamide toxicological pathways and interactions remains incompletely characterized.
Oluwabukola Mary Farodoye, Titilayomi Ayomide Otenaike, Daniela Moreira Mombach, Monica Medeiros Silva, Amos Olalekan Abolaji, Elgion Lucio Da Silva Loreto   +5 more
wiley   +1 more source

Spontaneous recovery from anti-NMDAR encephalitis

, 2012
Encephalitis associated with antibodies (Abs) to the N-methyl-D-aspartate receptor (NMDAR) can occur in a paraneoplastic or non-paraneoplastic form.
Servidei, Serenella, Evoli, Amelia, Frisullo, Giovanni, Marra, Camillo, Spinelli, Pietro   +4 more
core   +1 more source

Fertility outcomes and ovarian function recovery after anti‐NMDAR encephalitis: A retrospective cohort study

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Acute hypothalamic–pituitary–ovarian axis suppression is common in anti‐NMDAR encephalitis, yet ovarian function and fertility recover favorably even in teratoma‐associated cases, supporting reassuring long‐term reproductive prognoses. Abstract Introduction Anti‐N‐methyl‐D‐aspartate receptor (anti‐NMDAR) encephalitis predominantly affects women of ...
Jia Wang, Jie Ding, Han Cai, YingXiang Wang, HaoTian Wu   +4 more
wiley   +1 more source

Background excitatory input extends the duration of NMDAR spikes.

, 2014
(A1–4) Dendritic NMDAR spikes triggered in different terminal branches (30 synapses; 100 trials) in the absence (control) and presence of 900, 1200 and 1500 background excitatory synapses. Single trials (grey) and average (solid colour).
R. Angus Silver (247219), Daniel T. Ruedt (555294), Frederic Lanore (555295), Matteo Farinella (247211), Padraig Gleeson (247205)   +4 more
core   +1 more source

Pharmacological Potential of 3-Benzazepines in NMDAR-Linked Pathophysiological Processes

, 2023
The number of N-Methyl-D-aspartate receptor (NMDAR) linked neurodegenerative diseases such as Alzheimer’s disease and dementia is constantly increasing. This is partly due to demographic change and presents new challenges to societies.
Nathalie Strutz-Seebohm, Guiscard Seebohm, Nadine Ritter, Paul Disse, Bernhard Wünsch   +4 more
core   +1 more source