Results 111 to 120 of about 43,559 (247)

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

NMDAR model parameters used in EONS.

, 2015
NMDAR model parameters used in EONS.
Jean-Marie C. Bouteiller (191819), Michel Baudry (191855), Eric Y. Hu (815542), Renaud Greget (191809), Nicolas Ambert (191837), Serge Bischoff (191850), Sushmita L. Allam (815541), Theodore W. Berger (191853)   +7 more
core   +1 more source

A CASE SERIES ON ANTI NMDAR ENCEPHALITIS

, 2017
N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune neurological disorder arising from the generation of antibodies which binds to the synaptic proteins.
Sherin Alexander, Reshma Reji, Meenu Vijayan   +2 more
core   +2 more sources

Natural variations in maternal care determine sensitivity to glucocorticoid regulation of hippocampal synaptic plasticity and function in adult rats

European Journal of Psychotraumatology, 2012
Rationale : Variations in maternal care in the rat associate with robust differences in hippocampal synaptic plasticity and learning in the offspring. In addition, differences in stress reactivity associate with variations in maternal care.
Rosemary C. Bagot
doaj   +1 more source

Elevated Serum and Cerebrospinal Fluid CD138 in Patients With Anti-N-Methyl-d-Aspartate Receptor Encephalitis

Frontiers in Molecular Neuroscience, 2019
BackgroundCD138 (also known as syndecan-1) is an important component of endothelial cell glycocalyx, and it is reportedly involved in negative regulation of various inflammatory processes. The clinical implications of circulating and cerebrospinal fluid (
Jiajia Zhu, Yongqi Li, Dong Zheng, Zhanhang Wang, Suyue Pan, Jia Yin, Honghao Wang   +6 more
doaj   +1 more source

Molecular Pathogenesis of Anti-NMDAR Encephalitis

, 2020
Anti-NMDAR encephalitis is a recently identified autoimmune disease, described by an immune-mediated loss of NMDA glutamate receptors, resulting in progressive mental deterioration.
Wei Yi, Zhihong Jian, Hao Ding, Creed M Stary, Xiaoxing Xiong   +4 more
core  

Incremental induction of NMDAR-STP and NMDAR-LTP in the CA1 area of ventral hippocampal slices relies on graded activation of discrete NMDA receptors [PDF]

N-methyl-D-aspartate receptor (NMDAR)-dependent short- and long-term types of potentiation (STP and LTP, respectively) are frequently studied in the CA1 area of dorsal hippocampal slices (DHS).
Michael-Titus, Adina T., Ingram, Rachael, Jane, David E., Volianskis, Arturas, Michael-Titus, AT, Volianskis, R, Georgiou, John, Jane, DE, Collingridge, GL, Volianskis, Rasa, Collingridge, Graham L., Georgiou, J, Ingram, R, Volianskis, A   +13 more
core   +1 more source

Monoclonal humanized monovalent antibody blocking therapy for anti-NMDA receptor encephalitis

Nature Communications
Anti-NMDA receptor (NMDAR) encephalitis is a devastating disease with severe psychiatric and neurological symptoms believed to be caused by pathogenic autoantibodies that bind to the N-terminal domain (NTD) of the NMDAR GluN1 subunit (GluN1-NTD ...
Atsuo Kanno, Takuya Kito, Masashi Maeda, Shanni Yamaki, Yasushi Amano, Takuya Shimomura, Margarita Anisimova, Naomi Kanazawa, Koichiro Suzuki, Amir Razai, Takuma Mihara, Kaori Kubo, Takeshi Shimada, Koji Nakamura, Naoko Nomura, Yuji Kondo, Akira Okimoto, Azusa Sugiyama, Deborah Park, Ivar Stein, Samuel Petshow, Valentin Vandendoren, Sanela Bilic, Roghiye Kazimi, Vallari Eastman, Scott J. Snipas, Mathew Mitchell, Mari Maurer, Marty Jefson, Jay Lichter, Daisuke Yamajuku, Hiroki Shirai, Megumi Adachi, Daniel J. Hoeppner, Satoshi Kubo, Karen Zito, Takahiro Iizuka, Peter Flynn, Mitsuyuki Matsumoto   +38 more
doaj   +1 more source

Kinesin-1 Regulates Extrasynaptic Targeting of NMDARs and Neuronal Vulnerability Toward Excitotoxicity

iScience, 2019
Summary: N-methyl-D-aspartate (NMDA) receptor (NMDAR) is highly compartmentalized in neurons, and its dysfunction has been implicated in various neuropsychiatric and neurodegenerative disorders.
Raozhou Lin, Zhigang Duan, Haitao Sun, Man-Lung Fung, Hansen Chen, Jing Wang, Chi-Fai Lau, Di Yang, Yu Liu, Yanxiang Ni, Zai Wang, Ju Cui, Wutian Wu, Wing-Ho Yung, Ying-Shing Chan, Amy C.Y. Lo, Jun Xia, Jiangang Shen, Jian-Dong Huang   +18 more
doaj   +1 more source

Mild Focal Cooling Decouples Dendrites to Reconfigure Cortical Output

Advanced Science, Volume 13, Issue 34, 19 June 2026.
Mild cooling of the cortical surface selectively modulates apical dendritic excitability, plasticity, and somato‐dendritic coupling, while uncoupling these effects from basal dendrites, and reshapes apical‐driven responses in barrel cortex during whisker touch.
Meisam Habibi Matin, Shulan Xiao, Krishna Jayant   +2 more
wiley   +1 more source