Results 131 to 140 of about 43,559 (247)

Progress in the preparation of an active immunization model of anti-N-methyl-D-aspartate receptor encephalitis in animals

Frontiers in Immunology
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is the most common form of autoimmune encephalitis, and its primary immunologic mechanism is that NMDA antibodies bind to the NMDA receptor, causing NMDAR to internalize and weaken to trigger ...
Kuikui Zeng, Yuting Liu, Sai Yang, Lingjuan Liu   +3 more
doaj   +1 more source

Channel Dysfunction as the Basis for Comorbidities in Multiple Sclerosis and Depression

Archiv der Pharmazie, Volume 359, Issue 6, June 2026.
Ion channel remodelling induced by neuroinflammation in multiple sclerosis alters neuronal excitability and immune signalling, creating shared molecular pathways that link multiple sclerosis pathology to depression and reveal novel pharmacological targets.
Nicole Rychlik, Kay Jüngling, Sven G. Meuth, Thomas Budde, Marta Méndez‐Couz   +4 more
wiley   +1 more source

Neurocognitive Aging Following Acute Illness: Pathobiology and a Framework for Developing Neurotherapeutic Agents

Brain and Behavior, Volume 16, Issue 6, June 2026.
In this review, we discuss the scientific basis for how neurocognitive aging occurs after critical illness, including sepsis, trauma, and burns, and the clinical need to develop therapies to reduce inflammation, protect the blood–brain barrier, remove senescent cells, and enhance neuroplasticity.
Errin Lawrence, Daniel Fulton, Poppy Brown, Subashini Suresh, Mark Morris, Paraskevi Goggolidou, Sree Chaithanya, Marcus Abbawy, Amelia Wild, Prashant Nasa, Niharika A. Duggal, Fang Gao‐Smith, Zubair Ahmed, Suresh Renukappa, Tonny Veenith   +14 more
wiley   +1 more source

A comparison of NMDAR-antibody detection methods

, 2017
N-Methyl-D-Aspartate receptor antibody (NMDAR-ab) encephalitis is the most common antibody-mediated encephalitis. We compared four NMDAR-Ab assay methods: 1) live (a, L-CBA) or fixed (b, F-CBA) cell-based assays (CBA); 2) immunohistochemistry (IHC); 3) a
Thouin, Anais, Leslie Jacobson, Angela Vincent, Jacobson, Leslie, Sarosh Irani, Matteo Gastaldi, Vincent, Angela, Woodhall, Mark, Irani, Sarosh, Anaïs Thouin, Gastaldi, Matteo, Mark Woodhall   +11 more
core   +1 more source

Increased NMDAR activity and GluN2A-NMDAR silent synapse expansion induced by chronic benzodiazepine treatment

Neuropharmacology
Benzodiazepines (BZDs) are critical sedative, anticonvulsant, and anxiolytic drugs that potentiate inhibitory GABAergic neurotransmission. However, clinical utility is hampered by drug tolerance and a hyperexcitable withdrawal syndrome characterized by neuronal excitation/inhibition (E/I) imbalance.
Caitlyn A. Chapman, Nadya Povysheva, Jon W. Johnson, Tija C. Jacob   +3 more
openaire   +3 more sources

Ocular Adverse Events Associated With Antidepressants: A Large‐Scale Data Analysis From the FAERS Database

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
This decadal FAERS study (2015–2024) identifies 62,020 ocular adverse events (AEs) across 39 antidepressants, highlighting ocular neuromuscular disorders as a key risk. NDDIs show the strongest associations, while SSRIs exhibit the broadest signal spectrum.
Yiming Peng, Yichen Cao, Hanhan Liu, Junlong Ma, Guoping Yang   +4 more
wiley   +1 more source

Global disparities in the recognition, diagnosis, and management of seizures or epilepsy of autoimmune etiology

Epilepsia Open, Volume 11, Issue 3, Page 922-934, June 2026.
Abstract Objective Despite advancements in “autoimmune epilepsy,” more accurately referred to herein as seizures or epilepsy of autoimmune etiology, significant variability exists in its recognition, diagnosis, and management internationally. This study assessed clinicians' understanding, access to diagnostic tools, and treatment practices across ...
Emily Guarasci, Robyn Whitney, Adrian Budhram, Maryam Nabavi Nouri   +3 more
wiley   +1 more source

Future Perspectives of NMDAR in CNS Disorders

Molecules
Neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases are among the leading causes of physical and cognitive disability across the globe. Fifty million people worldwide suffer these diseases, and that number is expected to rise as the population ages. Ictus is another pathology that also courses with neurodegeneration and is a leading
Toni Capó, Joan Biel Rebassa, Iu Raïch, Jaume Lillo, Pau Badia, Gemma Navarro, Irene Reyes-Resina   +6 more
openaire   +3 more sources

KREO Prevents CUMS‐Induced Depressive‐Like Behavior via Modulation of the BDNF Signaling Pathway

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
This study showed that Chinese Kushui Rose Essential Oil (KREO) can alleviate depressive symptoms, increase voluntary activity, and enhance exploratory behavior in mice induced with chronic unpredictable mild stress (CUMS) by elevating serotonin (5‐HT) levels and reducing hyperactivity of the hypothalamic–pituitary–adrenal (HPA) axis.
Yanni Wang, Zhaorong Yue, Manjie Xu, Wenjun Xu, Weizhong Zhang, Xiaolong Li, Qinghong Liu, Kailong Guan, Zewen Zhang, Yang Li, Xin Wang, Hongyu Li   +11 more
wiley   +1 more source

Severe Abdominal Pain as a Prominent Clinical Manifestation of Anti‐DPPX Autoimmune Encephalitis: A Case Report and Systematic Review

Immunity, Inflammation and Disease, Volume 14, Issue 6, June 2026.
ABSTRACT Background Anti‐dipeptidyl‐peptidase‐like protein 6 encephalitis (DPPXE) is an exceptionally rare form of autoimmune encephalitis characterized by a highly heterogeneous clinical phenotype. Methods In this study, we report a Chinese patient presenting with severe abdominal pain as a prominent symptom; furthermore, we conducted a systematic ...
Difang Shi, Haohao Wu, Baogang Huang, Yan Zheng, Jia Liu, Jianjian Bao, Fengming Xu, Kang Du   +7 more
wiley   +1 more source