Results 141 to 150 of about 43,559 (247)

Paraneoplastic NMDA encephalitis, a case report and an extensive review of available literature

Radiology Case Reports
Anti-N-methyl-D-aspartate receptor (NMDAr) encephalitis is a prevalent autoimmune condition marked by diverse neuropsychiatric symptoms, primarily impacting young females.
Hamza Alzghoul, MD, Ferdous Kadri, MD, Mohamed F. Ismail, MD, Robeer Youssef, Mustafa Shamaileh, MD, Ahmad R. Al-Assi, Liliya Adzhieva, MD, Bashar Alzghoul, MD   +7 more
doaj   +1 more source

Pediatric Therapeutic Plasma Exchange: Characterization of Practice, Epidemiology, and Safety Profile at a Children's Hospital in the United States

Journal of Clinical Apheresis, Volume 41, Issue 3, June 2026.
ABSTRACT There is a need to better understand the indications and safety profiles for therapeutic plasma exchange (TPE) in children. We aimed to assess pediatric TPE practice at a large academic center by retrospective chart review from 2011 to 2022. Patient demographics and clinical information including American Society for Apheresis (ASFA) category ...
Benjamin C. Lee, Brian D. Adkins, Ayda Javanbakht, Hung S. Luu, Daniel K. Noland   +4 more
wiley   +1 more source

Diabetic Peripheral Neuropathy: Molecular Staging, Risk Factors, Therapeutics, and Emerging Trends

Med Research, Volume 2, Issue 2, Page 309-342, June 2026.
The heterogeneous landscape of DPN can be unified through a tripartite pathogenic model encompassing progressive stages of metabolic dysregulation, chronic inflammation, and overt neuronal damage. Within this framework, six clinical subtypes were identified, namely, hyperglycemia‐driven, dyslipidemia‐driven, inflammation‐driven, dysvascularity‐driven ...
Xiaofeng Dai, Mingze Tang
wiley   +1 more source

Amplificación del ADN de la subunidad-1 del receptor N-Metil-D-Aspartato (NMDAR-1) en el hipotálamo ovino mediante la técnica de RT-PCR

Revista Científica, 2010
El receptor N-metil-D-aspartato (NMDAR), uno de los principales receptores de los aminoácidos excitatorios, ha sido involucrado en el control de la secreción de la hormona luteinizante (LH) al facilitar la liberación de la hormona liberadora de la ...
Ana Ruiz, Roger Kittok
doaj  

Clinical feature of anti-myelin oligodendrocyte glycoprotein antibody-associated cerebral cortical encephalitis with cerebrospinal fluid anti-N-methyl-D-aspartate receptor antibody co-positivity: a single center case series

Immunological Medicine
Anti-myelin oligodendrocyte glycoprotein antibody-associated cerebral cortical encephalitis (MOG-CCE) occasionally exhibits cerebrospinal fluid (CSF) anti-N-methyl-D-aspartate receptor (NMDAR) antibody co-positivity; however, its clinical relevance ...
Kotaro Haruna, Junko Ishii, Kazuma Ota, Hajime Yoshimura, Satoru Fujiwara, Michi Kawamoto   +5 more
doaj   +1 more source

Combination Versus Monotherapy in Acute Anti‐LGI1 Encephalitis: A Real‐World Dose Optimization Analysis

Neuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.
Combined IVIg and 500 mg/day IVMP achieve superior efficacy over monotherapies in anti‐LGI1 encephalitis, with optimal safety. Higher‐dose IVMP (1000 mg) accelerates response but increases adverse events, particularly in diabetic patients. Cognitive deficits persist post‐treatment, necessitating long‐term management.
Yao Tan, Ming Sun, Qinqin Liu, Beibei Huang, Chao Wu, Jie Lu, Donglin Zhu   +6 more
wiley   +1 more source

Potentiation increases monotonically with constant NMDAR currents with no decay.

, 2013
The top panel in each subfigure shows a raster plot, with input spikes (red) and E cell spikes (blue), enlarged over the first 250 ms to show detail. Second panels are AMPAR conductance over time.
Kamal Sen (324262), Shane Lee (368861), Nancy Kopell (368863)   +2 more
core   +1 more source

Mechanism‐Based Polypharmacy as a Repurposing Strategy: The Case of D‐Cycloserine and Lurasidone

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Modern psychiatric treatment often necessitates polypharmacy, yet combination regimens carry significant risks of metabolic burden and drug–drug interactions. There is growing interest in and clinical acceptance of rational, mechanism‐based drug combinations that are designed around desirable pharmacological properties rather than trial and ...
Avery D. Franzen, John S. Svendsen, Cassidy J. Kline, Susan Q. Shen   +3 more
wiley   +1 more source

Intermediate filaments link glutamate–aspartate transporter deficiency to cochlear synaptopathy

The FEBS Journal, Volume 293, Issue 12, Page 3461-3465, June 2026.
In a healthy ear, GLAST transporters in supporting cells clear excess glutamate to protect auditory connections. When GLAST is missing, glutamate accumulates and leads to the destruction of structural scaffolding within the postsynaptic nerve endings. This internal collapse causes a loss of synapses that are essential for hearing, ultimately resulting ...
Paul Emmerich Krumpoeck, Lukas David Landegger   +1 more
wiley   +1 more source

NMDAR Encephalitis, a model of synaptopathy

, 2017
Que se passe-t-il quand le système immunitaire attaque le cerveau ? Dans l'encéphalite à autoanticorps dirigés contre les récepteurs NMDA, le système immunitaire des patients dysfonctionne : au lieu de produire des anticorps pour combattre des organismes
Chefdeville, Aude
core