, 2020 Alzheimer’s disease (AD) is one of the most common forms of dementia among elder people, which is a progressive neurodegenerative disease that results from a chronic loss of cognitive activities.
Al Mamun, Abdullah +5 more
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Dynamic regulation of NMDAR function in the adult brain by the stress hormone corticosterone
Frontiers in Cellular Neuroscience, 2012 Stress and corticosteroids dynamically modulate the expression of synaptic plasticity at glutamatergic synapses in the developed brain. Together with alpha-amino-3-hydroxy-methyl-4-isoxazole propionic acid receptors (AMPAR), N-methyl-D-aspartate ...
Yiu Chung eTse +4 more
doaj +1 more source
Modeling anti-NMDAR encephalitis
, 2022 The anti-NMDAR encephalitis (NMDARE) is an autoimmune condition with so far unclear etiology and pathogenesis. It manifests with a heterogeneous clinical disease course and is diagnosed based on the presence of NMDAR1-autoantibodies (NMDAR1-AB) of the ...
Wilke, Justus
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Use and Safety of Immunotherapeutic Management of N -Methyl- d -Aspartate Receptor Antibody Encephalitis: A Meta-analysis [PDF]
, 2021 Importance: Overall, immunotherapy has been shown to improve outcomes and reduce relapses in individuals with N-methyl-d-aspartate receptor (NMDAR) antibody encephalitis (NMDARE); however, the superiority of specific treatments and combinations remains ...
Thomas, Terrence +9 more
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The NMDA receptor complex: a multifunctional machine at the glutamatergic synapse
Frontiers in Cellular Neuroscience, 2014 The N-methyl-D-aspartate receptors (NMDARs) are part of a large multiprotein complex at the glutamatergic synapse. The assembly of NMDARs with synaptic proteins offers a means to regulate NMDAR channel properties and receptor trafficking, and couples ...
Xuelai eFan, Wu Yang eJin, Yu Tian eWang
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24S-hydroxycholesterol and 25-hydroxycholesterol differentially impact hippocampal neuronal survival following oxygen-glucose deprivation. [PDF]
PLoS ONE, 2017 N-methyl-D-aspartate receptors (NMDARs), a major subtype of glutamate receptor mediating excitatory transmission throughout the CNS, participate in ischemia-induced neuronal death.
Min-Yu Sun +3 more
doaj +1 more source
PGC-1α Negatively Regulates Extrasynaptic NMDAR Activity and Excitotoxicity [PDF]
, 2012 Underexpression of the transcriptional coactivator PGC-1α is causally linked to certain neurodegenerative disorders, including Huntington's Disease (HD).
Vidal-Puig, Antonio +9 more
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The Effect on the Kidney in Patients With Anti-N-methyl D-aspartate Receptor Antibody Encephalitis
Frontiers in Neurology, 2021 Objectives: The function of the N-methyl-D-aspartate receptor (NMDAR) in the kidney has been studied. However, the effect on the kidney from anti-NAMDAR antibody encephalitis has not been investigated thus far.Methods: Case data were collected from 82 ...
Lizhi Liu +8 more
doaj +1 more source
Recovery From Anti-Nmdar Encephalitis: A Qualitative Content Analysis
, 2019 Background: Limited research has explored patient perceptions of recovery from anti-NMDAR encephalitis. This study sought to identify factors that patients viewed as influencing their recovery from this severe, immune-mediated neurological disorder ...
McKeon, G, Scott, J, Parker, S
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Computational investigation of the changing patterns of subtype specific NMDA receptor activation during physiological glutamatergic neurotransmission. [PDF]
PLoS Computational Biology, 2011 NMDA receptors (NMDARs) are the major mediator of the postsynaptic response during synaptic neurotransmission. The diversity of roles for NMDARs in influencing synaptic plasticity and neuronal survival is often linked to selective activation of multiple ...
Pallab Singh +3 more
doaj +1 more source