Results 31 to 40 of about 43,559 (247)

Differentially Altered NMDAR Dependent and Independent Long-Term Potentiation in the CA3 Subfield in a Model of Anti-NMDAR Encephalitis

Frontiers in Synaptic Neuroscience, 2018
Purpose: Autoantibodies against NMDA receptors (NMDAR) in the cerebrospinal fluid (CSF) from anti-NMDAR encephalitis patients have been suggested to be pathogenic since in previous studies using patient CSF, NMDAR-dependent processes such as long-term ...
Roman Blome, Willi Bach, Xiati Guli, Katrin Porath, Tina Sellmann, Christian G. Bien, Rüdiger Köhling, Timo Kirschstein   +7 more
doaj   +1 more source

Screening for anti-NMDAR encephalitis in psychiatry

, 2020
Anti-NMDAR encephalitis most commonly presents to psychiatric services, so early identification of this disorder is essential. We aim to validate the two screening criteria (Scott et al.
Warren, N, Flavell, Joshua, Warren, Nicola, Siskind, Dan, Blum, Stefan, Flavell, J, Siskind, D, Blum, S, Kisely, Steve, Swayne, A, Kisely, S, O'Gorman, C, O'Gorman, Cullen, Swayne, Andrew   +13 more
core   +1 more source

Pulsed Radiofrequency Decreases pERK and Affects Intracellular Ca2+ Influx, Cytosolic ATP Level, and Mitochondrial Membrane Potential in the Sensitized Dorsal Root Ganglion Neuron Induced by N-Methyl D-Aspartate

Journal of Pain Research, 2023
Ristiawan Muji Laksono,1,2 Handono Kalim,3 Mohammad Saifur Rohman,4 Nashi Widodo,5 Muhammad Ramli Ahmad,6 Willy Halim7 1Doctoral Program in Biomedical Science, Faculty of Medicine, Brawijaya University, Malang, Indonesia; 2Department of Anesthesiology ...
Laksono RM, Kalim H, Rohman MS, Widodo N, Ahmad MR, Halim W   +5 more
doaj  

Activation of neuronal N-methyl-d-aspartate receptor plays a pivotal role in Japanese encephalitis virus-induced neuronal cell damage

Journal of Neuroinflammation, 2018
Background Overstimulation of glutamate receptors, especially neuronal N-methyl-d-aspartate receptor (NMDAR), mediates excitatory neurotoxicity in multiple neurodegenerative diseases.
Zheng Chen, Xugang Wang, Usama Ashraf, Bohan Zheng, Jing Ye, Dengyuan Zhou, Hao Zhang, Yunfeng Song, Huanchun Chen, Shuhong Zhao, Shengbo Cao   +10 more
doaj   +1 more source

Case Report: Overlapping Multiple Sclerosis With Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A Case Report and Review of Literature

Frontiers in Immunology, 2020
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disorder mediated by NMDAR antibodies, typically manifesting as behavioral complaints, psychosis, seizures, movement disorders, hypoventilation, and autonomic dysfunction. In recent
Ying Huang, Qian Wang, Silin Zeng, Yaqing Zhang, Liangyu Zou, Xuejun Fu, Qianhui Xu   +6 more
doaj   +1 more source

Target cell-specific plasticity rules of NMDA receptor-mediated synaptic transmission in the hippocampus

Frontiers in Cellular Neuroscience, 2023
Long-term potentiation and depression of NMDA receptor-mediated synaptic transmission (NMDAR LTP/LTD) can significantly impact synapse function and information transfer in several brain areas. However, the mechanisms that determine the direction of NMDAR
Stefano Lutzu, Karina Alviña, Nagore Puente, Nagore Puente, Pedro Grandes, Pedro Grandes, Pablo E. Castillo, Pablo E. Castillo   +7 more
doaj   +1 more source

NMDA Receptor Autoantibodies in Autoimmune Encephalitis Cause a Subunit-Specific Nanoscale Redistribution of NMDA Receptors

Cell Reports, 2018
Summary: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a severe neuropsychiatric disorder mediated by autoantibodies against the GluN1 subunit of the NMDAR.
Laurent Ladépêche, Jesús Planagumà, Shreyasi Thakur, Irina Suárez, Makoto Hara, Joseph Steven Borbely, Angel Sandoval, Lara Laparra-Cuervo, Josep Dalmau, Melike Lakadamyali   +9 more
doaj   +1 more source

Neuronal NMDAR Currents of the Hippocampus and Learning Performance in Autoimmune Anti-NMDAR Encephalitis and Involvement of TNF-α and IL-6

Frontiers in Neurology, 2019
Among autoimmune encephalitis, patients with anti-N-methyl D- aspartate receptor (NMDAR) encephalitis typically present epileptic seizures, memory deficits and psychiatric symptoms.
Xu Wang, Chi Ma, Cai-Yun Liu, Guang-Jian Li, Ding Zhao, Dong-Feng Han   +5 more
doaj   +1 more source

N-Methyl-D-Aspartate Receptors in Hematopoietic Cells: What Have We Learned?

Frontiers in Physiology, 2020
The N-methyl-D-aspartate receptor (NMDAR) provides a pathway for glutamate-mediated inter-cellular communication, best known for its role in the brain but with multiple examples of functionality in non-neuronal cells.
Maggie L. Kalev-Zylinska, Maggie L. Kalev-Zylinska, James I. Hearn, Asya Makhro, Asya Makhro, Anna Bogdanova, Anna Bogdanova   +6 more
doaj   +1 more source

Effects of N-methyl-D-aspartate receptor knockdown and hypoxia/reoxygenation injury on the neuronal proteome and transcriptome

Frontiers in Molecular Neuroscience, 2022
IntroductionBrain tissue is extremely sensitive to hypoxia/reoxygenation (H/R) injury, which can easily cause irreversible damage to neurons. H/R injury can induce neuronal apoptosis through glutamate-mediated excitotoxicity.
Jinting He, Kaili Chen, Yujie Sui, Qiwei Yang   +3 more
doaj   +1 more source