Results 11 to 20 of about 43,559 (247)

NMDAR-activated PP1 dephosphorylates GluN2B to modulate NMDAR synaptic content [PDF]

Cell Reports, 2019
SUMMARY In mature neurons, postsynaptic NMDARs are segregated into two populations, synaptic and extrasynaptic, which differ in localization, function, and associated intracellular cascades. These two pools are connected via lateral diffusion, and receptor exchange between them modulates synaptic NMDAR content.
Chiu, Andrew M, Wang, Jiejie, Fiske, Michael P, Hubalkova, Pavla, Barse, Levi, Gray, John A, Sanz-Clemente, Antonio   +6 more
core   +7 more sources

α7nAchR/NMDAR coupling affects NMDAR function and object recognition [PDF]

Molecular Brain, 2013
The α7 nicotinic acetylcholine receptor (nAchR) and NMDA glutamate receptor (NMDAR) are both ligand-gated ion channels permeable to Ca2+ and Na+. Previous studies have demonstrated functional modulation of NMDARs by nAchRs, although the molecular mechanism remains largely unknown.
Li, Shupeng, Nai, Qiang, Lipina, Tatiana V, Roder, John C, Liu, Fang   +4 more
openaire   +5 more sources

CSF IgA NMDAR antibodies are potential biomarkers for teratomas in anti-NMDAR encephalitis [PDF]

Neurology Neuroimmunology & Neuroinflammation, 2015
To evaluate the presence of immunoglobulin A (IgA) subtype of anti-NMDA receptor (NMDAR) antibodies (IgA-NMDAR-Abs) in the CSF of patients with immunoglobulin G (IgG)-NMDAR-Ab encephalitis and to describe the potential association with a specific clinical pattern.The retrospective analysis for the presence of IgA-NMDAR-Abs in 94 CSF samples from ...
Desestret, Virginie, Chefdeville, Aude, Viaccoz, Aurélien, Bost, Chloe, Ducray, François, Picard, Géraldine, Rogemond, Veronique, Chaffois, Marie-Oceane, Blanc, Charlotte, Bardel, Claire, Treilleux, Isabelle, Pascual, Olivier, Antoine, Jean-Christophe, Delattre, Jean-Yves, Honnorat, Jerome   +14 more
openaire   +3 more sources

Anti-NMDAR encephalitis for psychiatrists: the essentials [PDF]

BJPsych Bulletin, 2021
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis predominantly presents with psychiatric symptoms. Psychiatrists need to be alert to this diagnostic possibility, especially in female adolescents and young adults, as exemplified by the real (de-identified) case outlined below.
Beattie, Matthew, Goodfellow, John, Oto, Maria, Krishnadas, Rajeev   +3 more
openaire   +4 more sources

Characterization of NMDAR-Independent Learning in the Hippocampus [PDF]

Frontiers in Behavioral Neuroscience, 2011
It is currently thought that memory formation requires the activation of NMDA receptors (NMDARs) in the hippocampus. However, recent studies indicate that these receptors are not necessary for all forms of learning. The current experiments examine this issue using context fear conditioning in mice.
Tayler, Kaycie Kuss, Lowry, Elizabeth, Tanaka, Kazumasa, Levy, Brynne, Reijmers, Leon, Mayford, Mark, Wiltgen, Brian J.   +6 more
openaire   +4 more sources

Combined Inhibition of TRPM4/NMDA Receptor Complex and Extrasynaptic NMDA Receptors Is Candidate Therapeutic Target for Suppression of Epileptic Seizures and Improvement of Cognitive Impairments. [PDF]

Pharmacol Res Perspect
ABSTRACT Cognitive impairments are important therapeutic targets in epilepsy medication; however, effective pharmacological treatments for epilepsy patients with comorbid cognitive impairment have not been established. Effects of chronic administration of MK‐801 (noncompetitive NMDA receptor inhibitor), memantine (low‐affinity extrasynaptic‐NMDA ...
Okada M, Okubo R, Oka T, Motomura E.
europepmc   +2 more sources

Ectopic NMDAR expression in cancer unmasks germline-encoded autoimmunity. [PDF]

Nature
Autoimmunity and anG-cancer immunity lie on the same biological conGnuum1,2 , but their link remains obscure. The paraneoplasGc neurological syndrome anG-NMDA receptor (NMDAR) encephaliGs (ANRE) is a paradigm for their connecGvity3 given that ...
Kleeman SO, Michalski K, Zhao X, Steigerwald R, Ferrer M, Levett L, Ertel E, Schultz A, Simorowski N, Moody P, Wee TL, Valente C, Fox S, Makuch M, Thomsen S, Harrison R, Regan C, Preall J, Gao Q, Thomas D, Habel J, Rubino R, Irani S, Furukawa H, Janowitz T.   +24 more
europepmc   +2 more sources

N-methyl-D-aspartate receptor hypofunction as a potential contributor to the progression and manifestation of many neurological disorders

Frontiers in Molecular Neuroscience, 2023
N-methyl-D-aspartate receptors (NMDA) are glutamate-gated ion channels critical for synaptic transmission and plasticity. A slight variation of NMDAR expression and function can result in devastating consequences, and both hyperactivation and ...
Bin Dong, Yang Yue, Han Dong, Yuehui Wang   +3 more
doaj   +1 more source

Prodromal headache in anti‐NMDAR encephalitis: An epiphenomenon of NMDAR autoimmunity [PDF]

Brain and Behavior, 2018
AbstractObjectiveTo investigate the nature of prodromal headache in anti‐NMDA receptor (NMDAR) encephalitis.MethodsRetrospective review of the clinical information of 39 patients with anti‐NMDAR encephalitis admitted between January 1999 and September 2017. Five patients with an atypical presentation were excluded. Thus, in 34 patients (median 27 years
Naomi Tominaga, Naomi Kanazawa, Atsushi Kaneko, Juntaro Kaneko, Eiji Kitamura, Hiroto Nakagawa, Kazutoshi Nishiyama, Takahiro Iizuka   +7 more
openaire   +2 more sources

Staggering of Subunits in NMDAR Channels [PDF]

Biophysical Journal, 2002
Functional N-methyl-D-aspartate receptors (NMDARs) are heteromultimers formed by NR1 and NR2 subunits. The M3 segment, as contributed by NR1, forms the core of the extracellular vestibule, including binding sites for channel blockers, and represents a critical molecular link between ligand binding and channel opening.
Sobolevsky, Alexander I., Rooney, LeeAnn, Wollmuth, Lonnie P.   +2 more
openaire   +2 more sources