Results 1 to 10 of about 43,559 (247)

Anti-NMDAR antibodies, the blood–brain barrier, and anti-NMDAR encephalitis

Frontiers in Neurology, 2023
Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is an antibody-related autoimmune encephalitis. It is characterized by the existence of antibodies against NMDAR, mainly against the GluN1 subunit, in cerebrospinal fluid (CSF). Recent research
Niya Wang, Kunhua Wu, Zhu Hongyan
exaly   +5 more sources

Autism-linked protein POSH balances NMDAR signaling via a self-limiting kinase-scaffold loop [PDF]

iScience
Summary: POSH (plenty of SH3 domains), an autism-linked scaffold protein, is essential for N-methyl-D-aspartate receptor (NMDAR) complex assembly, and its loss causes ASD-like social deficits in mice. However, the synaptic mechanism remains unclear. Here,
Minghui Yao, Shuo Wang, Feng Zhang, Lei Shi, Zhiheng Xu   +4 more
doaj   +2 more sources

Molecular Docking of Active Compound of Lavandula angustifolia Mill Essential Oil against N-methyl-D-aspartate (NMDA) Receptor

Jurnal Farmasi dan Ilmu Kefarmasian Indonesia, 2022
Background: Lavender oil is widely known to possess a relaxant effect to relieve stress, anxiety, and depression. Linalyl acetate, linalool, geranyl acetate, and β-caryophyllene were the major constituents of lavender oil that potentially act on NMDAR (N-
Baiq Risky Wahyu Lisnasari, Aniek Setiya Budiatin, Chrismawan Ardianto, Junaidi Khotib   +3 more
doaj   +1 more source

Case Report: Three Case Reports of Rapidly Progressive Dementias and Narrative Review

Case Reports in Neurology, 2022
Rapidly progressive dementia (RPD) is a heterogeneous group of diseases characterized by cognitive impairment and other neurological disorders developed in a short span of fewer than 2 years.
Carlos Andrés Clavijo, Ana María Portilla Buenaventura, Galo Santiago Benavides Albornoz, Juan José Muñoz Cabrera, María Camila Murillo Reyes, Alejandra Chauvez Gallego, Carlos Alberto Hurtado González, Sebastian Ospina Otalvaro, Carlos Steven Marmolejo Escobar, Karen Julieth Quebrada Mera, Paola Andrea Gutiérrez Lenis, Lina María Arango García, Armando Lucumí   +12 more
doaj   +1 more source

A Metabolomics-Based Study on NMDAR-Mediated Mitochondrial Damage through Calcium Overload and ROS Accumulation in Myocardial Infarction

Frontiers in Bioscience-Landmark, 2023
Background: Coronary artery disease is a leading public health problem. However, the mechanisms underlying mitochondrial damage remain unclear. The present study verified and explored the novel mechanisms underlying ischemic injury based on a metabolomic
Yuanyuan Wang, Li He, Dan Du, Zeyi Cheng, Chaoyi Qin   +4 more
doaj   +1 more source

Immunoregulation and antidepressant effect of ketamine

Translational Neuroscience, 2021
Major depressive disorder (MDD) is a common mental health disorder that brings severe disease burden worldwide. Traditional antidepressants are mainly targeted at monoamine neurotransmitters, with low remission rates and high recurrence rates.
Zhang Nan, Yao Lihua, Wang Peilin, Liu Zhongchun   +3 more
doaj   +1 more source

The effects of sodium benzoate exposure on learning and neurobehavior during the prepubertal period in rats

Türk Biyokimya Dergisi, 2022
Exposure to food additives, especially during the critical development period, has been associated with some behavioral disorders and learning difficulties in childhood.
İlhan İlter, Kumbul Doğuç Duygu, Büyükbayram Halil İbrahim, Aşcı Çelik Dilek, Gurbuz Nilgun, Gultekin Fatih   +5 more
doaj   +1 more source

Overlapping anti-NMDAR encephalitis and multiple sclerosis: A case report and literature review

Frontiers in Immunology, 2023
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune-mediated disease characterized by complicated neuropsychiatric symptoms and the detection of cerebrospinal fluid antibodies against the GluN1 subunit of the NMDAR. With the proposed
Pan Liu, Hui Yan, Haizhe Li, Chunhua Zhang, Yanfang Li   +4 more
doaj   +1 more source

Cre-Activation in ErbB4-Positive Neurons of Floxed Grin1/NMDA Receptor Mice Is Not Associated With Major Behavioral Impairment

Frontiers in Psychiatry, 2021
Extensive evidence suggests a dysfunction of the glutamate NMDA receptor (NMDAR) in schizophrenia, a severe psychiatric disorder with putative early neurodevelopmental origins, but clinical onset mainly during late adolescence.
Anne S. Mallien, Natascha Pfeiffer, Miriam A. Vogt, Sabine Chourbaji, Rolf Sprengel, Rolf Sprengel, Peter Gass, Dragos Inta, Dragos Inta   +8 more
doaj   +1 more source

The relevance of NMDA receptor antibody-specific index for diagnosis and prognosis in patients with anti-NMDA receptor encephalitis

Scientific Reports, 2023
The clinical implications of the presence of anti-N-methyl-D-aspartate receptor (NMDAR)-specific intrathecal immunoglobulin G synthesis and whether it determines the diagnosis of anti-NMDAR encephalitis have not been thoroughly investigated yet.
Martin W. Hümmert, Konstantin F. Jendretzky, Karin Fricke, Marina Gingele, Dominica Ratuszny, Nora Möhn, Corinna Trebst, Thomas Skripuletz, Stefan Gingele, Kurt-Wolfram Sühs   +9 more
doaj   +1 more source