Results 101 to 110 of about 880,423 (146)

Determination of no-observed-adverse-effect levels and eliciting doses in a representative group of peanut-sensitized children

Journal of Allergy and Clinical Immunology, 2006
Current labeling practices for allergenic foods like peanut can be inadequate. For future regulatory and industry guidelines, information on no-observed-adverse-effect levels (NOAELs) and eliciting doses (EDs) for allergenic foods is necessary.To determine NOAEL and ED in a representative group of peanut-sensitized children, relate these data to ...
Annebeth E, Flinterman, Suzanne G, Pasmans, Maarten O, Hoekstra, Yolanda, Meijer, Els, van Hoffen, Edward F, Knol, Susan L, Hefle, Carla A, Bruijnzeel-Koomen, André C, Knulst   +8 more
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Statistical Uncertainty in the No-Observed-Adverse-Effect Level

Toxicological Sciences, 1989
The no-observed-adverse-effect level (NOAEL) is a dose value that U.S. EPA reduces by uncertainty factors (UF) and modifying factors (MF) to obtain a reference dose (RfD) for input to regulatory decision making. Whether the true added risk at the NOAEL is below an acceptable level, however, is a source of statistical uncertainty itself.
K G, Brown, L S, Erdreich
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No-Observed-Adverse-Effect Levels in Severity Data

Journal of the American Statistical Association, 1997
Abstract Toxicity data are often categorized by severity of response and dose level with the assumption that there is a tolerated dose below which there is no toxicity. For data from a controlled experiment, the largest observed dose at or below the tolerated dose is called the no-observed-adverse-effect level (NOAEL).
Takashi Yanagawa, Yasuki Kikuchi, Kenneth G. Brown   +2 more
openaire   +1 more source

Determination of an Acute No-Observed-Adverse-Effect Level (NOAEL) for Copper in Water

Regulatory Toxicology and Pharmacology, 2001
A prospective, double-blind controlled study was designed to determine the acute no-observed-adverse-effect level (NOAEL) of nausea in an apparently healthy population of 179 individuals who drank copper-containing water as the sulfate salt. Subjects were recruited at three different international sites and given a blind, randomly selected dose (0, 2 ...
M, Araya, M C, McGoldrick, L M, Klevay, J J, Strain, P, Robson, F, Nielsen, M, Olivares, F, Pizarro, L A, Johnson, K A, Poirier   +9 more
openaire   +2 more sources

A new approach to deriving community exposure guidelines from “no-observed-adverse-effect levels”

Regulatory Toxicology and Pharmacology, 1990
The world community desires accurate and reliable information about possible health hazards from exposure to chemicals in the environment. For example, Title III of the Superfund Amendments and Reauthorization Act (SARA, U.S. Congress, 1986) requires plant operators to disclose data on air, water, and waste emissions for over 300 chemicals.
S C, Lewis, J R, Lynch, A I, Nikiforov
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Is there a role for the no observed adverse effect level in safety pharmacology?

Journal of Pharmacological and Toxicological Methods, 2020
In nonclinical toxicology the highest dose or exposure without test article-related adverse effects, known as the No Observed Adverse Effect Level (NOAEL), is a variable that may be determined. In safety pharmacology the vast majority of the endpoints measured are quantitative numeric functional endpoints such as changes in heart rate, blood pressure ...
Mow, Tomas, Andersen, Ninette K., Dragsted, Nils, Lassen, Anders B., Laursen, Morten, Bass, Alan S., Valentin, Jean Pierre, Markgraf, Carrie, Authier, Simon, Baird, Theodore J., Bhatt, Siddhartha, Traebert, Martin, Leishman, Derek J., Jones, David, Curtis, Michael J.   +14 more
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Assessment of the no-observed-adverse-effect level (NOAEL) of gallic acid in mice

Food and Chemical Toxicology, 2001
Gallic acid is a naturally occurring plant phenol obtained by the hydrolysis of tannins and is known to show some pharmacological activities. The purpose of this paper is to establish the safety of gallic acid in mice. In this study, acute administration of gallic acid even at a dose as high as 5 g/kg body weight did not produce any signs of toxicity ...
K, Rajalakshmi, H, Devaraj, S, Niranjali Devaraj   +2 more
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