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Hormesis Shifts the No-Observed-Adverse-Effect Level (NOAEL) [PDF]

Dose-Response, 2021
Data from recent dose-response toxicological studies suggest that the no-observed-adverse-effect-level (NOAEL) may depend upon whether hormesis is present. A further examination of these data supports this hypothesis by showing that the NOAEL was greater
Evgenios Agathokleous, Costas Saitanis, Athina Markouizou   +2 more
doaj   +5 more sources

Determination of No-Observed-Adverse-Effect Level Ammonia in White Mice Through CD4 Expression [PDF]

Dose-Response, 2018
Background: Ammonia is one of the chemical compounds that can cause acute and chronic effects to the workers. The purpose of this study is to determine the no-observed-adverse-effect level (NOAEL) ammonia in white mice.
Abdul Rohim Tualeka, Jihan Faradisha, Rizky Maharja   +2 more
doaj   +5 more sources

Estimating the no-observed-adverse-effect-level (NOAEL) of hormetic dose-response relationships in meta-data evaluations [PDF]

MethodsX, 2021
The number of studies reporting hormetic responses is rapidly increasing, and quantitative evaluations are needed to improve the understanding of hormetic dose responses.
Evgenios Agathokleous, Michael N Moore, Edward J Calabrese   +2 more
doaj   +4 more sources

Glyphosate below no-observed-adverse-effect level exacerbates fatty liver hemorrhagic syndrome in laying hens [PDF]

Poultry Science
Glyphosate (GLY) can disturb gut microbiota homeostasis through inhibiting bacterial shikimate pathway to pose a health challenge to animals and humans.
Jingbo Liu, Guozheng Sun, Hongna Zhang, Hui Liu, Xiaohan Wang, Zengmin Miao   +5 more
doaj   +4 more sources

A change-point regression approach for estimating no observed adverse effect level from systematic review. [PDF]

J Clin Biochem Nutr, 2023
Systematic reviews can be used not only to evaluate the efficacy and usefulness of a drug or food ingredient, but also as a safety assessment method. One of the aims of safety assessment is to estimate the no observed adverse effect level and the lowest observed adverse effect level.
Kuramochi Y, Hayamizu K.
europepmc   +3 more sources

CORAL: model for no observed adverse effect level (NOAEL). [PDF]

Mol Divers, 2015
Abstract The in vivo repeated dose toxicity (RDT) test is intended to provide information on the possible risk caused by repeated exposure to a substance over a limited period of time. The measure of the RDT is the no observed adverse effect level (NOAEL) that is the dose at which no effects are observed, i.e., this endpoint indicates the ...
Toropov AA, Toropova AP, Pizzo F, Lombardo A, Gadaleta D, Benfenati E.   +5 more
europepmc   +4 more sources

Hypercalcemia and a "no observed adverse effect level" intake of vitamin D. [PDF]

CMAJ, 2019
There are many reasons why the diagnosis of vitamin D toxicity in the recent case report by Auguste and colleagues[1][1] was probably wrong and the result of a red herring. The patient had been taking 8000–10 000 IU of vitamin D daily for 2.5 years, during which time serum creatinine levels ...
Vieth R.
europepmc   +4 more sources

Transgenerational effects of developmental neurotoxicity induced by exposure to a no-observed-adverse-effect level (NOAEL) of neonicotinoid pesticide clothianidin. [PDF]

J Vet Med Sci, 2023
Neonicotinoid pesticides (NNs) transfer rapidly from mother to offspring, which exhibit neurobehavioral effects. However, no studies have investigated NNs' transgenerational effects. We exposed F0 generation mice (mothers) to a no-observed-adverse-effect level (NOAEL) of clothianidin (CLO) during gestation and lactation, and examined the adult ...
Shoda A, Murata M, Kimura M, Hara Y, Yonoichi S, Ishida Y, Mantani Y, Yokoyama T, Hirano T, Ikenaka Y, Hoshi N.   +10 more
europepmc   +3 more sources

Acute Oral Toxicity of Tetrodotoxin in Mice: Determination of Lethal Dose 50 (LD50) and No Observed Adverse Effect Level (NOAEL) [PDF]

Toxins, 2017
Tetrodotoxin (TTX) is starting to appear in molluscs from the European waters and is a hazard to seafood consumers. This toxin blocks sodium channels resulting in neuromuscular paralysis and even death. As a part of the risk assessment process leading to
Paula Abal, M. Carmen Louzao, Alvaro Antelo, Mercedes Alvarez, Eva Cagide, Natalia Vilariño, Mercedes R. Vieytes, Luis M. Botana   +7 more
doaj   +2 more sources

Effect of clothianidin exposure at the no-observed-adverse-effect level (NOAEL) in a mouse model of atopic dermatitis. [PDF]

J Vet Med Sci
The effects of exposure to clothianidin (CLO), a neonicotinoid pesticide (NN), on the thymus and intestinal microbiota were recently revealed. Immune cells express nicotinic acetylcholine receptors (nAChRs), an NN target, suggesting CLO may disrupt the immune system. However, the relationship between CLO and atopic dermatitis (AD) is unknown.
Ishida Y, Yonoichi S, Hara Y, Shoda A, Kimura M, Murata M, Ito M, Nunobiki S, Yoshimoto A, Mantani Y, Yokoyama T, Hirano T, Matsuo E, Ikenaka Y, Hoshi N.   +14 more
europepmc   +4 more sources