Results 11 to 20 of about 1,885,648 (256)

Effect of chronic T-2 toxin exposure in rabbit bucks, determination of the No Observed Adverse Effect Level (NOAEL) [PDF]

Animal Reproduction Science, 2013
T-2 toxin (T-2) was administered to adult Pannon White (n = 10/group) male rabbits for 65 days, first in a suspension by gavage (0.05, 0.1 or 0.2 mg/animal/day), and secondly mixed into the feed (0.33 and 0.66 mg/kg feed). In the first experiment 0.1 mg T-2 exposure resulted in temporary decrease in feed intake, slower increase in the gonadotropin ...
Kovács, Melinda, Tornyos, Gábor, Matics, Zsolt, Mézes, Miklós, Balogh, Krisztián, Rajli, Veronika, Bodnár, Zsófia, Rusvai, Miklós, Mándoki, Míra, Cseh, Sándor   +9 more
openaire   +4 more sources

Bisphenol A impairs mitochondrial function in the liver at doses below the no observed adverse effect level. [PDF]

J Korean Med Sci, 2012
Bisphenol A (BPA) has been reported to possess hepatic toxicity. We investigated the hypothesis that BPA, below the no observed adverse effect level (NOAEL), can induce hepatic damage and mitochondrial dysfunction by increasing oxidative stress in the liver. Two doses of BPA, 0.05 and 1.2 mg/kg body weight/day, were administered intraperitoneally for 5
Moon MK, Kim MJ, Jung IK, Koo YD, Ann HY, Lee KJ, Kim SH, Yoon YC, Cho BJ, Park KS, Jang HC, Park YJ.   +11 more
europepmc   +3 more sources

Interpretation of toxicological research data in establishing the no observed adverse effect level (NOAEL) for medicinal products

Регуляторные исследования и экспертиза лекарственных средств
INTRODUCTION. Toxicological studies of new pharmaceuticals in laboratory animals represent an obligatory stage in drug risk assessment, designed to identify toxic effects, their potential reversibility, and dependence on dose and/or systemic exposure ...
K. L. Kryshen, Ya. A. Gushchin, N. M. Faustova, S. V. Gushchina, Zh. Yu. Ustenko, A. E. Katelnikova, K. T. Sultanova, A. A. Matichin, V. A. Vavilova, Ya. G. Murazov, M. V. Miroshnikov, M. A. Kovaleva, D. V. Shubin, V. G. Makarov, M. N. Makarova   +14 more
doaj   +2 more sources

Toxicity of diclofenac sodium salt in Yucatan minipigs (Sus scrofa) following 4 weeks of daily intramuscular administration

Toxicology Reports, 2021
Diclofenac sodium salt (DSS) is a widely used nonsteroidal anti-inflammatory drug. The present study was performed under good laboratory practice (GLP) regulations to investigate the toxicity of DSS after 4 weeks of repeated intramuscular administration ...
Hyung-Sun Kim, Goo-Hwa Kang, Mi-Jin Yang, Hee-Jeong Ahn, Su-Cheol Han, Jeong Ho Hwang   +5 more
doaj   +1 more source

Subchronic safety evaluation of hot-water extract from thinned immature mangos (Mangifera indica ‘Irwin’): 90-days oral toxicity study in rats

Toxicology Reports, 2021
Thinned immature fruit of the mango tree (Mangifera indica ‘Irwin’) are handled as waste. In this study, we conducted a 90-days toxicity study in male and female Sprague Dawley rats to evaluate the safety of a hot-water extract of thinned immature mango ...
Hayato Tajiri, Wataru Tanaka, Masakatsu Takashima, Hiroki Matsuyama, Takuya Sugita, Kenta Hidaka, Hiroyuki Sakakibara   +6 more
doaj   +1 more source

DETERMINING THE NO-OBSERVED-ADVERSE-EFFECT LEVEL IN CATEGORICAL DATA [PDF]

Bulletin of informatics and cybernetics, 1994
Summary: We discuss the determination of the no-observed-adverse-effect level (NOAEL) from categorical data. Recently a method which incorporated the order restriction into the multiple testing was proposed by \textit{K. G. Brown} and \textit{L. S. Erdreich} [Fund. Appl. Toxicology 13, 235-244 (1989)].
Nishiyama, Harutoshi, Yanagawa, Takashi
openaire   +2 more sources

Repeated dose (90 days) oral toxicity study of ursolic acid in Han-Wistar rats

Toxicology Reports, 2020
Background: Ursolic acid (UA) has been used in alternative medicine for decades, and there has been a great interest in its medicinal properties. Despite this increased interest, a detailed long-term toxicity study has not been performed.
Lotte Geerlofs, Zhiyong He, Sa Xiao, Zhi-Cheng Xiao   +3 more
doaj   +1 more source

Safety, toxicity and pharmacokinetic assessment of oral Withaferin-A in mice

Toxicology Reports, 2022
Withaferin-A (WA) is the principle component of Withania somnifera (Ashwagandha). It has several biological activities including anti-cancer, anti-diabetic, neuroprotective, hepatoprotective and immune-modulatory properties.
Saurabh Kumar Gupta, Shraddha Jadhav, Dievya Gohil, Girish Ch. Panigrahi, Rajiv Kumar Kaushal, Khushboo Gandhi, Anand Patil, Preeti Chavan, Vikram Gota   +8 more
doaj   +1 more source

Effect of imidacloprid on hepatotoxicity and nephrotoxicity in male albino mice

Toxicology Reports, 2014
Imidacloprid (IC) is a systemic insecticide related to the tobacco toxin nicotine. IC is a toxic substance frequently used into combat insects, rodents and plants pests and other creatures that can pose problems for agriculture.
Yasir Arfat, Nasir Mahmood, Muhammad Usman Tahir, Maryam Rashid, Sameer Anjum, Fan Zhao, Di-Jie Li, Yu-Long Sun, Lifang Hu, Chen Zhihao, Chong Yin, Peng Shang, Ai-Rong Qian   +12 more
doaj   +1 more source

Diminishment of Nrf2 Antioxidative Defense Aggravates Nephrotoxicity of Melamine and Oxalate Coexposure

Antioxidants, 2021
Chronic kidney disease (CKD) usually causes devastating healthy impacts on patients. However, the causes affecting the decline of kidney function are not fully revealed, especially the involvement of environmental pollutants.
Chia-Fang Wu, Chia-Chu Liu, Yi-Chun Tsai, Chu-Chih Chen, Ming-Tsang Wu, Tusty-Jiuan Hsieh   +5 more
doaj   +1 more source