Results 21 to 30 of about 1,885,648 (256)

Conclusions of the French Food Safety Agency on the toxicity of bisphenol A [PDF]

open access: yes, 2011
Since more than 10 years, risk assessment of bisphenol A (BPA) is debated at the international level. In 2008, the U.S. National Toxicology Program (NTP) expressed some concern for adverse effects, at current level of exposure to BPA, on developmental ...
Arnich, Nathalie   +12 more
core   +3 more sources

Statistical issues on the no-observed-adverse-effect level in categorical response. [PDF]

open access: yesEnvironmental Health Perspectives, 1994
The determination of the value of the no-observed-adverse-effect level (NOAEL) when observed responses can be categorized by severity (categorical data) and sample sizes are small is discussed. The common situation of only two categories, where only the presence or absence of an effect is observed, is addressed first (dichotomous data). Three tests for
T, Yanagawa, Y, Kikuchi, K G, Brown
openaire   +2 more sources

Expression profiling of key pathways in rat liver after a one-year feeding trial with transgenic maize MON810 [PDF]

open access: yes, 2019
In a recent one-year feeding study, we observed no adverse effects on tissue level in organs of rats fed with the genetically-modified maize MON810. Here, we assessed RNA expression levels of 86 key genes of the apoptosis-, NF-кB-, DNA-damage response ...
Bohmer, Marc   +4 more
core   +1 more source

Toxicity and Hypolipidemic Activity of Lansiumamide B in Mice [PDF]

open access: yesShipin Kexue
Objective: To explore the hypolipidemic activity and toxic side effect of lansiumamide B (LB) from chicken-heart shaped wampee (Clausena lansium) seeds in C57BL/6J mice fed on a high-fat-diet (HFD) model.
CHEN Danni, WANG Sainan, YIN Zhaochun, XU Zewen, GUO Xiaomin, LI Kangyuan, WANG Jiawei, CHEN Liping, CAO Yong, XIAO Suyao
doaj   +1 more source

Safety Evaluation for Restorin® NMN, a NAD+ Precursor

open access: yesFrontiers in Pharmacology, 2021
NAD+ is an abundant molecule in the body and vital to all living cells. NAD+ levels decline with age, and this decline correlates with age-related diseases. Therefore, sustaining NAD+ levels offers potential benefits to healthspan and longevity.
John Turner   +3 more
doaj   +1 more source

In Silico Prediction of Organ Level Toxicity: Linking Chemistry to Adverse Effects [PDF]

open access: yes, 2017
In silico methods to predict toxicity include the use of (Quantitative) Structure-Activity Relationships ((Q)SARs as well as grouping (category formation) allowing for read-across.
Cronin, M.T.D   +5 more
core   +1 more source

Firm efficiency, foreign ownership and CEO gender in corrupt environments [PDF]

open access: yes, 2017
We study the effects of corruption on firm efficiency using a unique dataset of private firms from 14 Central and Eastern European countries from 2000 to 2013.
Hanousek, Jan   +2 more
core   +2 more sources

The no-observed-adverse-effect level of phthalates promotes proliferation and cell cycle progression in normal human breast cells

open access: yesTaiwanese Journal of Obstetrics & Gynecology, 2023
Objective: The data on the association between phthalates and breast cancer risk remains inconsistent. This study aimed to explore the possible mechanism of low-dose exposures of phthalates, including Butyl benzyl phthalate (BBP), di(n-butyl) phthalate ...
Fang-Ping Chen   +2 more
doaj   +1 more source

Preexisting diabetes mellitus had no effect on the no-observed-adverse-effect-level of acetaminophen in rats

open access: yesThe Journal of Toxicological Sciences, 2020
Information on the safety of chemical substances in patients with various preexisting conditions remains limited. Acetaminophen was added to the basal diet at 0, 80, 253, 800, 2530, or 8000 ppm and administered to type 2 diabetes mellitus rats (GK/Jcl) and the control male rats (Wistar) for 13 weeks.
Sosuke, Kishi   +8 more
openaire   +3 more sources

Objective Assessment of Surgical Operative Performance by Observational Clinical Human Reliability Analysis (OC-HRA):A Systematic Review [PDF]

open access: yes, 2020
Background: Both morbidity and mortality data (MMD) and learning curves (LCs) do not provide information on the nature of intraoperative errors and their mechanisms when these adversely impact on patient outcome.
Cuschieri, Alfred, Tang, Benjie
core   +2 more sources

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