Nobiletin mitigates benign prostatic hyperplasia by suppressing prostate cell proliferation through regulation of cell cycle progression, signaling pathways, transcription factor activity, and the androgen-signaling axis [PDF]
Frontiers in PharmacologyBackground and aimBenign prostatic hyperplasia (BPH) involves androgen-driven proliferation with reduced apoptosis. Current 5α-reductase inhibitors can cause adverse effects, motivating safer options.
Jun-Hui Song +12 more
doaj +2 more sources
Co-administration of nobiletin and tetrahydrocurcumin enhanced the cytotoxicity to breast cancer through inhibiting CYP1A1 enzyme: from the perspective of pharmacokinetic interactions [PDF]
Discover OncologyBackground & objectives The introduction of traditional Chinese medicine to the treatment of breast cancer increases the risk of adverse herb-herb interactions.
Hongming Song +6 more
doaj +2 more sources
Nobiletin Attenuates Adipogenesis and Promotes Browning in 3T3-L1 Adipocytes Through Exosomal miRNA-Mediated AMPK Activation [PDF]
Current Issues in Molecular BiologyNobiletin, a citrus-derived polymethoxylated flavone, has been reported to exert anti-obesity effects, but its molecular mechanisms remain poorly understood.
Shweta Chauhan +4 more
doaj +2 more sources
Experimental and Molecular Medicine, 2019 Liver injury: Citrus peel to the rescue Nobiletin, an antioxidant found in citrus peel, may protect the liver from reperfusion injury, damage following blood flow interruption.
Theodomir Dusabimana, Sang Won Park
exaly +2 more sources
Nobiletin restores the intestinal barrier of HFD-induced obese mice by promoting MHC-II expression and lipid metabolism [PDF]
Molecular MedicineThe incidence of obesity is increasing annually worldwide. A high-fat diet (HFD) causes intestinal barrier damage, but effective interventions are currently unavailable.
Ni Yang +4 more
doaj +2 more sources
Nobiletin enhances Pirarubicin chemosensitivity of breast cancer cell MDA-MB-231 by regulating PER2 [PDF]
E3S Web of Conferences, 2021 To explore the potential mechanism of nobiletin in improving the sensitivity of breast cancer MDA-MB-231 cells to Pirarubicin. MDA-MB-231 cells were randomly divided into Control group, Nobiletin group, Pirarubicin group and Nobiletin co-Pirarubicin ...
Yuan Fahu, Liao Xinghua, Zhang Tongcun
doaj +1 more source
Phytomedicine Plus, 2022 Background: Nobiletin, a polymethoxy flavone contained in the peel of Citrus reticulata, has been known to have health benefits especially those related to improvement of type 2 diabetes.
Yukiko K. Kaneko +5 more
doaj +1 more source
Nobiletin resolves left ventricular and renal changes in 2K-1C hypertensive rats
Scientific Reports, 2022 This study investigated the effects of nobiletin on cardiorenal changes and the underlying mechanisms involved in two-kidney, one-clip (2K-1C) hypertension.
Metee Iampanichakul +7 more
doaj +1 more source
Cancer Biology & Medicine, 2021 Objective: Natural extracts, including nobiletin, have been reported to enhance the efficacy and sensitivity of chemotherapeutic drugs. However, whether and how nobiletin affects tumor growth and progression in renal cell carcinoma (RCC) are still ...
Tingting Chen +8 more
doaj +1 more source
Nobiletin promotes the pyroptosis of breast cancer via regulation of miR‐200b/JAZF1 axis
Kaohsiung Journal of Medical Sciences, 2021 Nobiletin is a polymethoxylated flavone present in citrus fruits, which has been reported to have inhibitory effects on tumorigenesis of cancers. However, the biological function of nobiletin in breast cancer (BC) is largely unknown.
Ji‐Guo Wang +3 more
doaj +1 more source