Results 11 to 20 of about 6,271 (203)

Endothelium-independent vasodilator effects of nobiletin in rat aorta

Journal of Pharmacological Sciences, 2019
Nobiletin is a one of the polymethoxyflavones contained in the peel of citrus fruits, such as Citrus depressa. In this study, the effect of nobiletin-induced relaxation on phenylephrine (PE)-induced contraction of endothelium-denuded rat aorta was ...
Hisako Kaneda, Rieko Otomo, Noriyasu Sasaki, Toshinori Omi, Tsuyhoshi Sato, Takeharu Kaneda   +5 more
doaj   +3 more sources

Pharmacological actions of nobiletin in the modulation of platelet function [PDF]

British Journal of Pharmacology, 2015
Background and Purpose The discovery that flavonoids are capable of inhibiting platelet function has led to their investigation as potential antithrombotic agents.
Ali, Marfoua, Crescente, Marilena, Flora, Gagan, Gibbins, Jon, Jones, Chris, Moraes, Leo, Roweth, Harvey, Stainer, Alexander, Unsworth, Amanda, Vaiyapuri, Sakthivel   +9 more
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Effect of nobiletin on experimental model of epilepsy [PDF]

Translational Neuroscience, 2018
The effects of nobiletin, a plant-derived flavonoid was examined against pentylenetetrazole (PTZ)-induced seizures. The study also aimed to assess whether nobiletin potentiated the effects of antiepileptic drug clonazepam (CZP).
Yang Baowang, Wang Jing, Zhang Ni
doaj   +3 more sources

Nobiletin and 3′-Demethyl Nobiletin Activate Brown Adipocytes upon β-Adrenergic Stimulation

Biological and Pharmaceutical Bulletin, 2022
Brown adipose tissue (BAT) specifically regulates energy expenditure via heat production. Nobiletin (NOB), a natural polymethoxylated flavone present in citrus fruits, can activate thermogenesis in the BAT of high-fat diet-induced obese mice. The activity of BAT is directly regulated by β-adrenergic stimulation.
Fumiko, Kihara-Negishi, Naoki, Ohkura, Yuka, Takahashi, Toshiyuki, Fujita, Yasuhiro, Nakamura, Keiji, Maruyama, Tetsuta, Oshitari, Shinji, Yamaguchi   +7 more
openaire   +2 more sources

Mitochondrial Target of Nobiletin's Action [PDF]

Natural Product Communications, 2016
Nobiletin is an O-methylated flavonoid found in citrus peels that have anticancer, antiviral, neuroprotective, anti-inflammatory activities and depending on the cell types exhibits both pro- or anti-apoptotic properties. We have found that nobiletin decreases oxygen consumption by bovine brain isolated mitochondria in the presence of glutamate and ...
Nino, Sharikadze, Natia, Jojua, Maia, Sepashvili, Elene, Zhuravliova, David G, Mikeladze   +4 more
openaire   +2 more sources

Nobiletin: A Citrus Isolate to Make Sepsis Less Sour [PDF]

Inflammation, 2016
Septic shock remains a major concern in critically ill patients. Morbidity, as reflected by cardiovascular instability and sequential organ failure, is high and mortality ranges from 20 to 50 % [1]. Treatment options are scarce and mainly causeoriented and symptomatic.
Honoré, Patrick M, Jacobs, Rita, Hendrickx, Inne, De Waele, Elisabeth, Spapen, Herbert D   +4 more
openaire   +3 more sources

A review on recent advances on nobiletin in central and peripheral nervous system diseases

European Journal of Medical Research, 2023
In recent years, the role of nobiletin in neuronal disorders has received extensive attention. However, the study of nobiletin in the peripheral nervous system is limited.
Yueshan Pang, Juan Xiong, You Wu, Weijun Ding   +3 more
doaj   +1 more source

The citrus flavonoid nobiletin confers protection from metabolic dysregulation in high-fat-fed mice independent of AMPK[S]

Journal of Lipid Research, 2020
Obesity, dyslipidemia, and insulin resistance, the increasingly common metabolic syndrome, are risk factors for CVD and type 2 diabetes that warrant novel therapeutic interventions.
Nadya M. Morrow, Amy C. Burke, Joshua P. Samsoondar, Kyle E. Seigel, Andrew Wang, Dawn E. Telford, Brian G. Sutherland, Conor O'Dwyer, Gregory R. Steinberg, Morgan D. Fullerton, Murray W. Huff   +10 more
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Nobiletin suppresses cholangiocarcinoma proliferation via inhibiting GSK3β

International Journal of Biological Sciences, 2022
Background: Cholangiocarcinoma (CCA) is a type of hepatobiliary cancer characterized by uncontrolled cell proliferation, with a poor prognosis and high mortality. Nobiletin (NBT) is a promising anti-tumor compound derived from the peels of oranges and other citrus plants, citrus plant. But the effect of NBT on CCA remains unknown.
You, Liping, Lin, Jiacheng, Yu, Zhuo, Qian, Yihan, Bi, Yuting, Wang, Fang, Zhang, Lei, Zheng, Chao, Zhang, Jinghao, Li, Wenxuan, Cai, Yaxuan, Gao, Yueqiu, Kong, Xiaoni, Sun, Xuehua   +13 more
openaire   +2 more sources

Nobiletin, a Polymethoxy Flavonoid, Suppresses Bone Resorption by Inhibiting NFκB-Dependent Prostaglandin E Synthesis in Osteoblasts and Prevents Bone Loss Due to Estrogen Deficiency

Journal of Pharmacological Sciences, 2011
Nobiletin, a polymethoxy flavonoid, prevents cancer and inflammation, but the roles of nobiletin in bone are unclear. We examined the effects of nobiletin on bone resorption in vitro and on bone mass in ovariectomized (OVX) mice in vivo.
Suguru Harada, Tsukasa Tominari, Chiho Matsumoto, Michiko Hirata, Morichika Takita, Masaki Inada, Chisato Miyaura   +6 more
doaj   +1 more source