Results 21 to 30 of about 6,271 (203)

Nobiletin Decreases Inflammatory Mediator Expression in Tumor Necrosis Factor-Stimulated Human Periodontal Ligament Cells

Mediators of Inflammation, 2021
Nobiletin, a biologically active substance in the skin of citrus fruits, has been reported to be an effective anti-inflammatory, anticancer, and antimicrobial agent.
Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki   +2 more
doaj   +1 more source

Modulation of neurotrophic signaling pathways by polyphenols [PDF]

, 2015
Polyphenols are an important class of phytochemicals, and several lines of evidence have demonstrated their beneficial effects in the context of a number of pathologies including neurodegenerative disorders such as Alzheimer's and Parkinson's disease. In
Firuzi, Omidreza, Hosseini, Razieh, Moosavi, Fatemeh, Saso, Luciano   +3 more
core   +1 more source

Nobiletin, a NF‐κB signaling antagonist, promotes BMP‐induced bone formation

FASEB BioAdvances, 2023
The NF‐κB family of transcription factors plays an important role in skeletal development and bone homeostasis. In osteoblast cells, NF‐κB signaling has been shown to suppress survival, proliferation, and differentiation.
Thira Rojasawasthien, Michihiko Usui, William N. Addison, Takuma Matsubara, Tomohiko Shirakawa, Toshiyuki Tsujisawa, Keisuke Nakashima, Shoichiro Kokabu   +7 more
doaj   +1 more source

Nobiletin Induces Ferroptosis in Human Skin Melanoma Cells Through the GSK3β-Mediated Keap1/Nrf2/HO-1 Signalling Pathway

Frontiers in Genetics, 2022
Melanoma is an aggressive malignant skin tumour with an increasing global incidence. However, current treatments have limitations owing to the acquired tumour drug resistance.
Senling Feng, Yongheng Zhou, Hongliang Huang, Ying Lin, Yifeng Zeng, Shanshan Han, Kaikai Huang, Quanzhi Liu, Wenting Zhu, Zhongwen Yuan, Baoying Liang   +10 more
doaj   +1 more source

The potential for dietary factors to prevent or treat osteoarthritis [PDF]

, 2014
Osteoarthritis (OA) is a degenerative joint disease for which there are no disease-modifying drugs. It is a leading cause of disability in the UK. Increasing age and obesity are both major risk factors for OA and the health and economic burden of this ...
Bao, Yongping, Cassidy, Aedín, Clark, Ian M., Davidson, Rose K., Donell, Simon T., Green, Jonathan A., Hirst-Jones, Kimberley L., Jupp, Orla, Macgregor, Alexander J.   +8 more
core   +1 more source

Myricetin, the main flavonoid in Syzygium cumini leaf, is a novel inhibitor of platelet thiol isomerases PDI and ERp5 [PDF]

, 2020
Background: Flavonoids have been characterized as a prominent class of compounds to treat thrombotic diseases through the inhibition of thiol isomerases. Syzygium cumini is a flavonoid-rich medicinal plant that contains myricetin and gallic acid.
Ayyanar, Banno, Bekendam, Bi, Chagas, Chagas, Chang, Chen, Chung, Dang, De Bona, Dutta-Roy, Essex, Essex, Essex, Ghoshal, Giamogante, Giamogante, Holbrook, Inoue, Jarvis, Jasuja, Jayakumar, Jordan, Kang, Kehrel, Kim, Lahav, Lakowicz, Lescano, Lin, Lu, Mangin, Masuda, Navarro-Nuñez, Park, Raffaelli, Raturi, Sharma, Sousa, Stopa, Taylor, Trnkova, Wang, Ware, Wendelboe   +45 more
core   +1 more source

The impact of fruit flavonoids on memory and cognition [PDF]

, 2010
There is intense interest in the studies related to the potential of phytochemical-rich foods to prevent age-related neurodegeneration and cognitive decline.
Bhat, Haque, Jeremy P. E. Spencer, Joseph, Joseph, Joseph, Kempermann, Kuhn, Kuriyama, Spencer, Spencer   +10 more
core   +1 more source

Multifunctional role of Nobiletin in cancer chemoprevention.

Cellular and molecular biology (Noisy-le-Grand, France), 2022
The diversity of highly bioactive and pharmacologically active natural products which recognize essential biological targets having exquisite specificity, constitutes a massive pharmacological database for discovery of valuable drugs. The rapid accumulation of information has revealed chemopreventive role of nobiletin against wide variety of cancers ...
Durr-E-Shahwar, Malik, Rukset, Attar, Ulku, Ozbey, Mirna Azalea, Romero, Ishmuratova Margarita, Yulaevna, Jelena, Purenovic   +5 more
openaire   +3 more sources

The citrus flavone nobiletin reduces pro-inflammatory and pro-labour mediators in fetal membranes and myometrium: implications for preterm birth. [PDF]

PLoS ONE, 2014
Spontaneous preterm birth is the leading cause of infant death and of neurological disabilities in survivors. A significant proportion of spontaneous preterm births are associated with infection.
Carrington J Morwood, Martha Lappas
doaj   +1 more source

The pharmacokinetic study on the interaction between nobiletin and anemarsaponin BII in vivo and in vitro

Pharmaceutical Biology, 2021
Context The interaction between nobiletin and anemarsaponin BII could affect the pharmacological activity of these two drugs during their combination.
Jie Zhang, Meiling Fan, Xia Yu, Bin Zhang   +3 more
doaj   +1 more source