Results 41 to 50 of about 6,271 (203)

Nobiletin Inhibits Cell Viability via the SRC/AKT/STAT3/YY1AP1 Pathway in Human Renal Carcinoma Cells

Frontiers in Pharmacology, 2019
Nobiletin is a polymethoxy flavonoid isolated from Citrus depressa and Citrus reticulata. It has been reported that nobiletin can suppress tumors. We primarily explored the antitumor effects of nobiletin and the associated potential mechanisms in ACHN ...
Di Wei, Geng Zhang, Zheng Zhu, Yu Zheng, Fei Yan, Chongxian Pan, Zhiyong Wang, Xian Li, Fuli Wang, Ping Meng, Wanxiang Zheng, Zhao Yan, Dongsheng Zhai, Zifan Lu, Jianlin Yuan   +14 more
doaj   +1 more source

Nobiletin Protects Endothelial Cell Function via Upregulation of eNOS/ET-1 and Antioxidant Status-Related Genes under Nonstimulated and Inflammatory Conditions

Journal of Food Quality, 2022
Nobiletin, a natural polymethoxylated flavonoid compound, has been shown to exert a wide range of biological activities. However, there is limited evidence on the molecular mechanisms by which nobiletin modulates endothelial cell function. Our aim was to
Lu Li, Biyun Zhang, Ludovica De Pieri, Yue Wu, Karen Birch, Christine Boesch   +5 more
doaj   +1 more source

Nöroprotektif Etkili Bir Flavonoid: Nobiletin

Harran Üniversitesi Veteriner Fakültesi Dergisi, 2017
The use of flavonoids promises new approach for the treatment of neurodegenerative diseases. Nobiletine is a polymethoxy flavonoid found in the citrus peel. The neuroprotective effect of nobiletin has been demonstrated in vivo and in vitro. Nobiletine affects the signaling cascades associated with learning and memory, ...
Gül Fatma YARIM, Metin ÇENESİZ, Murat YARIM, Filiz KAZAK   +3 more
openaire   +2 more sources

Nobiletin, a Citrus Flavonoid That Improves Memory Impairment, Rescues Bulbectomy-Induced Cholinergic Neurodegeneration in Mice

Journal of Pharmacological Sciences, 2007
We have recently reported that nobiletin, a citrus flavonoid, improves impaired memory in olfactory-bulbectomized (OBX) mice, which have been widely utilized as a useful paradigm that shares some major clinical features of Alzheimer’s disease.
Akira Nakajima, Tohru Yamakuni, Mitsuya Haraguchi, Naoki Omae, Si-Young Song, Chieko Kato, Osamu Nakagawasai, Takeshi Tadano, Akihito Yokosuka, Yoshihiro Mimaki, Yutaka Sashida, Yasushi Ohizumi   +11 more
doaj   +1 more source

Nobiletin protected against hypertrophic cardiomyopathy via targeting PPARα. [PDF]

Front Pharmacol
BackgroundHypertrophic cardiomyopathy is an independent risk factor for heart failure. Citrus reticulata (C. reticulata) is a traditional Chinese medicine with a variety of chemical components and pharmacological effects. The mechanisms of C. reticulata for treating hypertrophic cardiomyopathy are still unclear.MethodsIn this study, we used network ...
Zhou K, Chen C, Cai H, Lian Z, Wang L, Li Q, Wang C, Wu X, Wang P.   +8 more
europepmc   +4 more sources

Cytoprotective Effect of Tangeretin in Hydrogen Peroxyde-inducedoxydative Stress on Human Umbilical Vein Endothelial Cells (HUVECs) [PDF]

, 2015
Oxydative stress is known as a major trigger in cardiovascular dysfunction that leads to hypertension, atherosclerosis, and chronic heart failure. Polymethoxyflavone such as tangeretin and nobiletin has been reported to have biological activity including
Jenie, I. M. (Ikhlas), Jenie, R. I. (Riris), Muflikhasari, H. A. (Haruma), Setiawan, I. M. (Irfan)   +3 more
core   +1 more source

Nobiletin and Xanthohumol Sensitize Colorectal Cancer Stem Cells to Standard Chemotherapy [PDF]

Cancers, 2021
Colorectal cancer (CRC) mortality is mainly caused by patient refractoriness to common anti-cancer therapies and consequent metastasis formation. Besides, the notorious toxic side effects of chemotherapy are a concurrent obstacle to be tackled. Thus, new treatment approaches are needed to effectively improve patient outcomes.
Alice Turdo, Antonino Glaviano, Giacomo Pepe, Federica Calap??, Stefania Raimondo, Micol Eleonora Fiori, Daniela Carbone, Manuela Giovanna Basilicata, Veronica Di Sarno, Carmine Ostacolo, Barbara Parrino, Stella Cascioferro, Camilla Pecoraro, Simone Di Franco, Diana Bellavia, Miriam Gaggianesi, Veronica Veschi, Melania Lo Iacono, Gloria Ganduscio, Vincenzo Davide Pantina, Laura Rosa Mangiapane, Maria Rita Bongiorno, Riccardo Alessandro, Matilde Todaro, Ruggero De Maria, Patrizia Diana, Pietro Campiglia, Giorgio Stassi, OSTACOLO, Carmine   +28 more
openaire   +3 more sources

Nobiletin enhances the development and quality of bovine embryos in vitro during two key periods of embryonic genome activation

Scientific Reports, 2021
In vitro culture can alter the development and quality of bovine embryos. Therefore, we aimed to evaluate whether nobiletin supplementation during EGA improves embryonic development and blastocyst quality and if it affects PI3K/AKT signaling pathway.
Karina Cañón-Beltrán, Yulia N. Cajas, Serafín Peréz-Cerezales, Claudia L. V. Leal, Ekaitz Agirregoitia, Alfonso Gutierrez-Adán, Encina M. González, Dimitrios Rizos   +7 more
doaj   +1 more source

Phytochemicals in regulating fatty acid β-oxidation: Potential underlying mechanisms and their involvement in obesity and weight loss [PDF]

, 2016
Excessive accumulation of fat as the result of more energy intake and less energy expenditure is known as obesity. Lipids are essential components in the human body and are vital for maintaining homeostasis and physiological as well as cellular ...
Mantso, Theodora, Panagiotidis, Mihalis, Rupasinghe, Vasantha, Sekhhon-Loodu, Satvir   +3 more
core   +1 more source

Nobiletin Induces Protective Autophagy Accompanied by ER-Stress Mediated Apoptosis in Human Gastric Cancer SNU-16 Cells

Molecules, 2016
Nobiletin, a major component of citrus fruits, is a polymethoxyflavone derivative that exhibits anticancer activity against several forms of cancer, including SNU-16 human gastric cancer cells.
Jeong Yong Moon, Somi Kim Cho
doaj   +1 more source