Results 51 to 60 of about 6,271 (203)

Nobiletin ameliorates high fat-induced disruptions in rhythmic glucagon-like peptide-1 secretion

Scientific Reports, 2022
The incretin hormone glucagon-like peptide-1 (GLP-1) is secreted by the intestinal L cell in response to nutrient intake. However, GLP-1 secretion also follows a circadian rhythm which is disrupted by the saturated fatty acid palmitate in vitro and high ...
Alexandre Martchenko, Andrew D. Biancolin, Sarah E. Martchenko, Patricia L. Brubaker   +3 more
doaj   +1 more source

Nobiletin ameliorates cardiac impairment and alleviates cardiac remodeling after acute myocardial infarction in rats via JNK regulation

Pharmacology Research & Perspectives, 2021
Nobiletin was found to protect against acute myocardial infarction (AMI)‐induced cardiac function decline and myocardial remodeling, although the dose–effect relationship and underlying pathways remained unclear.
Zumei Liu, Zhimin Gao, Lihuan Zeng, Zhenye Liang, Dechong Zheng, Xiaoqian Wu   +5 more
doaj   +1 more source

Inhibitory Effects of Metabolites of Nobiletin and 5‐hydroxy Nobiletin on Human Lung Cancer Cells

The FASEB Journal, 2012
Nobiletin (NBT) and 5‐hydroxy nobiletin (5HN) are unique polymethoxyflavones found in citrus fruits. We investigated the effects of NBT, 5HN, and their major metabolites, namely 4′‐hydroxy nobiletin (M1), 3′,4′‐dihydroxy nobiletin (M2), 3′,5‐dihydroxy nobiletin (M3), 4′,5‐dihydroxy nobiletin (M4), and 3′,4′,5‐trihydroxy nobiletin ...
Noppawat Charoensinphon, Jinkai Zheng, Ping Dong, Peiju Qiu, Thony Tran, Hang Xiao   +5 more
openaire   +1 more source

Polymethoxy Flavonoids, Nobiletin and Tangeretin, Prevent Lipopolysaccharide-Induced Inflammatory Bone Loss in an Experimental Model for Periodontitis

Journal of Pharmacological Sciences, 2012
Nobiletin, a polymethoxy flavonoid (PMF), inhibits systemic bone resorption and maintains bone mass in estrogen-deficient ovariectomized mice. This study examined the antiinflammatory effects of PMFs, nobiletin, and tangeretin on lipopolysaccharide (LPS)-
Tsukasa Tominari, Michiko Hirata, Chiho Matsumoto, Masaki Inada, Chisato Miyaura   +4 more
doaj   +1 more source

The leaves of Mediterranean mandarin could be used as an important source of hesperidin, nobiletin and tangeretin. : S20P04 [PDF]

, 2012
Citrus are rich in flavonoids such as flavones and flavanones. Recent studies have shown that these phytonutrients play a beneficial role for human health.
Bidel, Luc P.R., Durand, Marie V.S, Fanciullino, Anne Laure, Froelicher, Yann, Jay-Allemand, Christian, Ollitrault, Patrick   +5 more
core  

Preparation of nobiletin in self-microemulsifying systems and its intestinal permeability in rats

Journal of Pharmacy & Pharmaceutical Sciences, 2008
: PURPOSE. The objective of this study was to prepare nobiletin self-microemulsifying drug delivery systems (SMEDDS) and investigate its intestinal transport behavior using the single-pass intestinal perfusion (SPIP) method in rat. METHODS.
Jing Yao, Yun Lu, Jian Ping Zhou
doaj   +1 more source

Citrus phenylpropanoids and defence against pathogens. Part I: Metabolic profiling in elicited fruits [PDF]

, 2016
Penicillium spp. are among the major postharvest pathogens of citrus fruit. Induction of natural resistance in fruits constitutes one of the alternatives to chemical fungicides.
Ballester Frutos, Ana Rosa, Bovy, A.G., De Vos, R.C.H., González-Candelas, Luis, Lafuente, María Teresa   +4 more
core   +1 more source

Nobiletin alleviates cisplatin-induced ototoxicity via activating autophagy and inhibiting NRF2/GPX4-mediated ferroptosis

Scientific Reports
Nobiletin, a citrus polymethoxy flavonoid with antiapoptotic and antioxidative properties, could safeguard against cisplatin-induced nephrotoxicity and neurotoxicity.
Wenao Song, Li Zhang, Xiaolin Cui, Rongrong Wang, Jingyu Ma, Yue Xu, Yan Jin, Dawei Wang, Zhiming Lu   +8 more
doaj   +1 more source

Impact of flavonoids on cellular and molecular mechanisms underlying age-related cognitive decline and neurodegeneration [PDF]

, 2018
Purpose of Review: This review summarises the most recent evidence regarding the effects of dietary flavonoids on age-related cognitive decline and neurodegenerative diseases.
Flanagan, Emma, Hornberger, Michael, Müller, Michael, Vauzour, David   +3 more
core   +1 more source

Nobiletin inhibits breast cancer via p38 mitogen-activated protein kinase, nuclear transcription factor-κB, and nuclear factor erythroid 2-related factor 2 pathways in MCF-7 cells

Food & Nutrition Research, 2018
Introduction: Breast cancer is one of the most commonly diagnosed cancers in women, with a high mortality rate. Objective: In the present study, we evaluated the anticancer effect of nobiletin, a flavone glycoside, on the breast cancer cell line MCF-7 ...
Jianli Liu, Shuai Wang, Siqi Tian, Yin He, Hong Lou, Zhijun Yang, Yuchi Kong, Xiangyu Cao   +7 more
doaj   +1 more source