Frontiers in Physiology, 2021 Non-alcoholic steatohepatitis (NASH) is an inflammatory disorder that is characterized by chronic activation of the hepatic inflammatory response and subsequent liver damage.
Si-wei Wang +10 more
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Potensi Kemopreventif Ekstrak Etanolik Kulit Jeruk Keprok (Citrus Reticulata) Pada Karsinogenesis Sel Hepar Tikus Galur Sprague Dawley Terinduksi Dmba [PDF]
, 2011 Salah satu titik tangkap strategi penemuan agen kemopreventif kanker khususnya kanker hepar adalah melalui penghambatan proliferasi dan penekanan ekspresi onkogen c-Myc. Tangeretin, nobiletin, dan hesperidin adalah beberapa senyawa aktif dari kulit jeruk
Meiyanto, E. (Edy)
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Nobiletin affects circadian rhythms and oncogenic characteristics in a cell-dependent manner.
PLoS ONE, 2020 The natural product nobiletin is a small molecule, widely studied with regard to its therapeutic effects, including in cancer cell lines and tumors. Recently, nobiletin has also been shown to affect circadian rhythms via their enhancement, resulting in ...
Sujeewa S Lellupitiyage Don +6 more
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Journal of Pharmacological Sciences, 2011 .: To prove the pharmacological actions of honeybee royal jelly (RJ) on the nervous system, we examined the effects of RJ on CRE-mediated transcription. RJ increased CRE-mediated transcription in PC12D cells.
Hironori Fujiwara +8 more
doaj +1 more source
, 1998 現在日本は高齢化社会を迎えて疾病構造が大きく変わりつつある。最近でこそ病原性大腸菌O157の問題が浮上しているが，疾病全体から見ると従来の感染症は主要な疾患ではなくなり，これに替わって自己免疫疾患，悪性腫蕩，高齢に伴う退行性の心臓及び腎臓疾患，老年性痴呆，肝硬変などが治療の難しい疾病になってきている。このような疾病構造の変化は和漢薬方剤のニーズを徐々に増やしている。方剤の効果はそれを構成する生薬の品質の優劣に係わっているが，生薬は天然物に由来するため種々の品質のものが存在し ...
伏見 裕利 +3 more
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Pharmaceuticals, 2018 Polymethoxyflavonoids (PMFs) are a family of the natural compounds that mainly compise nobiletin, tangeretin, heptamethoxyflavone (HMF), and tetramethoxyflavone (TMF) in citrus fruits.
Shigeru Matsumoto +9 more
doaj +1 more source
Potency of Citrus Peels (Citrus Aurantiifolia (Cristm.) Swingle) Ethanolic Extract as Chemopreventive Agent Through Downregulation of C-myc Expression and Inhibition of 7.12-dimethylbenz[a]antrachene Induced Female Sprague Dawley Rats Breast Cell Proliferation [PDF]
, 2010 The using of natural-based medicine is growing rapidly in societies. Besides being cheap and affordable, natural-based medicine is relatively safer than the synthetic drugs.
Armandari, I. (Inna) +6 more
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Tangeretin regulates platelet function through inhibition of phosphoinositide 3-Kinase and cyclic nucleotide signaling [PDF]
, 2013 OBJECTIVE: Dietary flavonoids have long been appreciated in reducing cardiovascular disease risk factors, but their mechanisms of action are complex in nature.
Ali, Marfoua S. +6 more
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The Production Of Flavonoids (Quercetin And Hesperetin) From Callus Culture Of Citrus Aurantifolia (Christm & Panzer) Swingle [PDF]
, 1999 The application of plant tissue culture technique for plant flavonoids production shows some promising results. However, certain limitation exist mainly because many cultures do not produce significant amount of the characteristic compounds from the ...
Siti Mahyuni,
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Characterization and Antiproliferative Activity of Nobiletin‐Loaded Chitosan Nanoparticles
Journal of Nanomaterials, 2012 Nobiletin is a polymethoxyflavonoid with a remarkable antiproliferative effect. In order to overcome its low aqueous solubility and chemical instability, the use of nanoparticles as carriers has been proposed. This study explores the possibility of binding nobiletin to chitosan nanoparticles, as well as to evaluate their antiproliferative activity. The
Ana G. Luque-Alcaraz +7 more
openaire +1 more source