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Placebo and nocebo responses in drug trials of epilepsy

Epilepsy & Behavior, 2015
Placebo response can be defined as any therapeutic change on placebo, while the nocebo response is any ill effect during placebo exposure. Several meta-analytic approaches have investigated the extent of placebo response in randomized, placebo-controlled, clinical trials of focal epilepsies.
Zaccara, Gaetano   +2 more
openaire   +4 more sources

Nocebo response in Parkinson's disease: A systematic review and meta-analysis

Parkinsonism & Related Disorders, 2019
To estimate the magnitude of the nocebo response in Parkinson's disease and explore possible associations with study characteristics.Databases were searched up to February 2017. Placebo-controlled, parallel-group randomized controlled trials investigating pharmacological interventions in people with Parkinson's disease were included.
Leal Rato, Miguel   +8 more
openaire   +5 more sources

Increasing and dampening the nocebo response following medicine-taking: A randomised controlled trial

Journal of Psychosomatic Research, 2021
The nocebo effect is the adverse effects of treatment that cannot be attributed to a medicine. We investigated if we could increase or decrease nocebo responding following medicine taking. A nocebo explanation to reduce side effects was compared with a negative medication news item designed to increase side effects and a control condition.108 healthy ...
Kate, MacKrill   +2 more
openaire   +4 more sources

The placebo–nocebo response: Controversies and challenges from clinical and research perspective

European Neuropsychopharmacology, 2014
Placebo and nocebo responses fascinate, confuse, mystify and challenge. They are genuine social, cultural and psychobiological phenomena which can significantly modify the overall treatment outcome. The placebo-nocebo phenomenon represents a very good model for our better understanding the role of treatment context and how the words, indices, symbols ...
openaire   +4 more sources

Nocebo responses in randomized controlled trials of COVID-19 vaccines

Int. Journal of Clinical Pharmacology and Therapeutics, 2022
The aim of this study was to evaluate the frequency and magnitude of nocebo responses in -COVID-19 vaccine trials.We performed a meta-analysis of adverse effects (AEs), severe adverse effects (SAEs), withdrawal due to AEs, death, and immune-mediated SAEs observed in randomized controlled trials (RCTs) of COVID-19 vaccines.Four RCTs with a total of 119 ...
Young Ho, Lee, Gwan Gyu, Song
openaire   +2 more sources

Nocebo response: individual differences, network structure, and heterogeneity

2022
Nocebo effects have been well documented throughout the health and medical literature and are defined as the worsening of symptoms due to prior beliefs, negative-health information or suggestion (Colloca et al., 2020, New England Journal of Medicine).
Cottam, Martha, Terhune, Devin
openaire   +1 more source

Nonmaleficence, Nondisclosure, and Nocebo: Response to Open Peer Commentaries

The American Journal of Bioethics, 2017
In our target article, “When Respecting Autonomy Is Harmful: A Clinically Relevant Approach to the Nocebo Effect,” we advocate for selective nondisclosure of medication-related side effects based o...
John T. Fortunato   +2 more
openaire   +2 more sources

Gender and the nocebo response following conditioning and expectancy

Journal of Psychosomatic Research, 2009
To investigate the role of Pavlovian conditioning and expectancy and of gender on the nocebo effects.Conditioning experiment: Forty-eight healthy male and female volunteers were investigated for 3 days using a standard rotation procedure. Subjects in the experimental group received a salient oral stimulus prior to rotation; subjects in the control ...
Sibylle, Klosterhalfen   +6 more
openaire   +2 more sources

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