The role of pain expectancy and its confidence in placebo hypoalgesia and nocebo hyperalgesia. [PDF]
Camerone EM, Tosi G, Romano D.
europepmc +1 more source
Study protocols for the GEPard project: systematic analysis of sex- and gender-specific differences in the efficacy of perioperative pain management - a two-pronged approach. [PDF]
Floren S +7 more
europepmc +1 more source
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Placebo and nocebo responses in drug trials of epilepsy
Epilepsy & Behavior, 2015Placebo response can be defined as any therapeutic change on placebo, while the nocebo response is any ill effect during placebo exposure. Several meta-analytic approaches have investigated the extent of placebo response in randomized, placebo-controlled, clinical trials of focal epilepsies.
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Nocebo response in Parkinson's disease: A systematic review and meta-analysis
Parkinsonism & Related Disorders, 2019To estimate the magnitude of the nocebo response in Parkinson's disease and explore possible associations with study characteristics.Databases were searched up to February 2017. Placebo-controlled, parallel-group randomized controlled trials investigating pharmacological interventions in people with Parkinson's disease were included.
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The nocebo effect is the adverse effects of treatment that cannot be attributed to a medicine. We investigated if we could increase or decrease nocebo responding following medicine taking. A nocebo explanation to reduce side effects was compared with a negative medication news item designed to increase side effects and a control condition.108 healthy ...
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The placebo–nocebo response: Controversies and challenges from clinical and research perspective
European Neuropsychopharmacology, 2014Placebo and nocebo responses fascinate, confuse, mystify and challenge. They are genuine social, cultural and psychobiological phenomena which can significantly modify the overall treatment outcome. The placebo-nocebo phenomenon represents a very good model for our better understanding the role of treatment context and how the words, indices, symbols ...
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Nocebo responses in randomized controlled trials of COVID-19 vaccines
Int. Journal of Clinical Pharmacology and Therapeutics, 2022The aim of this study was to evaluate the frequency and magnitude of nocebo responses in -COVID-19 vaccine trials.We performed a meta-analysis of adverse effects (AEs), severe adverse effects (SAEs), withdrawal due to AEs, death, and immune-mediated SAEs observed in randomized controlled trials (RCTs) of COVID-19 vaccines.Four RCTs with a total of 119 ...
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Nocebo response: individual differences, network structure, and heterogeneity
2022Nocebo effects have been well documented throughout the health and medical literature and are defined as the worsening of symptoms due to prior beliefs, negative-health information or suggestion (Colloca et al., 2020, New England Journal of Medicine).
Cottam, Martha, Terhune, Devin
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Nonmaleficence, Nondisclosure, and Nocebo: Response to Open Peer Commentaries
The American Journal of Bioethics, 2017In our target article, “When Respecting Autonomy Is Harmful: A Clinically Relevant Approach to the Nocebo Effect,” we advocate for selective nondisclosure of medication-related side effects based o...
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Gender and the nocebo response following conditioning and expectancy
Journal of Psychosomatic Research, 2009To investigate the role of Pavlovian conditioning and expectancy and of gender on the nocebo effects.Conditioning experiment: Forty-eight healthy male and female volunteers were investigated for 3 days using a standard rotation procedure. Subjects in the experimental group received a salient oral stimulus prior to rotation; subjects in the control ...
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