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Placebo and Nocebo Responses, Cortisol, and Circulating Beta-Endorphin
Psychosomatic Medicine, 2003The experiment tested whether the placebo and nocebo responses could be mediated via modulation of stress.Ischemic pain was induced in healthy volunteers (N = 59). When pain reached "7" on a 10-point scale, two groups of subjects received information that a pain relieving (the Placebo group) or a pain increasing (the Nocebo group) substance was ...
Oddmund, Johansen +2 more
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Drug-Related Information Generates Placebo and Nocebo Responses That Modify the Drug Response
Psychosomatic Medicine, 1999Administration of the muscle relaxant carisoprodol and placebo was crossed with information that was agonistic or antagonistic to the effect of carisoprodol. It was investigated whether information alone induced physiological and psychological responses, and whether information modified the response to the drug.Half of the subjects received capsules ...
M A, Flaten, T, Simonsen, H, Olsen
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Placebo and nocebo responses in painful diabetic neuropathy: systematic review and meta-analysis
Pain, 2023Abstract This preregistered (CRD42021223379) systematic review and meta-analysis aimed to characterize the placebo and nocebo responses in placebo-controlled randomized clinical trials (RCTs) on painful diabetic neuropathy (PDN), updating the previous literature by a decade. Four databases were searched for PDN trials published in the past 20
Elisa Frisaldi +4 more
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What influences placebo and nocebo responses in Parkinson's disease?
Movement Disorders, 2018AbstractPlacebo treatment is associated with clinical improvements in many medical conditions, but is particularly important in Parkinson's disease because improvements are common, marked, and associated with objective neurochemical and neurophysiologic changes.
Natalie, Witek +2 more
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Mechanisms Involved in Placebo and Nocebo Responses and Implications for Drug Trials
Clinical Pharmacology & Therapeutics, 2011Drug trials often compare active drugs with inert placebos under double-blind conditions. This standard design is increasingly being questioned in light of recent progress in understanding the mechanisms behind the placebo response.1,2 The growing knowledge of the neurobiology of placebo is forcing us to reconsider the significance of the placebo in ...
Rief, W. +3 more
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Metaforest Algorithm Insights: Predictors of Nocebo Response in ADHD
Current PsychopharmacologyBackground: Predicting the nocebo response in randomized controlled trials (RCTs) is crucial as it can help minimize its influence and improve the evaluation of the side effects of interventions for ADHD. The aim of this study is to determine the effect of covariates related to study design, intervention, and patients’ characteristics on the nocebo ...
Mireia Porta +7 more
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Nocebo responses to high-voltage power lines: Evidence from a prospective field study
Science of The Total Environment, 2016Experimental studies suggest that nocebo responses might occur after exposure to equipment emitting electromagnetic fields such as high voltage power lines (HVPLs) or mobile phone base stations.The present study investigates to what extent health responses to a new HVPL can be explained by beliefs of residents regarding the health effects of HVPLs.We ...
Porsius, JT +4 more
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Placebo and nocebo responses in Parkinson's disease
2020Benedetti Fabrizio +6 more
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The placebo and nocebo responses in patients with epilepsy
2015Placebo and nocebo responses in epilepsy have been mainlyinvestigated by meta-analytic approaches aimed to evaluate the extent ofsuch phenomenon in randomized, controlled, clinical trials. These studiesreported placebo response rates (defined as proportion of patients with =50% improvement of seizures compared to baseline observations) rangingfrom 9.9%
Giovannelli F. +2 more
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