Results 1 to 10 of about 52,502 (285)

Assessment and management of pain/nociception in patients with disorders of consciousness or locked-in syndrome: A narrative review

Frontiers in Systems Neuroscience, 2023
The assessment and management of pain and nociception is very challenging in patients unable to communicate functionally such as patients with disorders of consciousness (DoC) or in locked-in syndrome (LIS).
Estelle A. C. Bonin, Estelle A. C. Bonin, Nicolas Lejeune, Nicolas Lejeune, Nicolas Lejeune, Emilie Szymkowicz, Emilie Szymkowicz, Vincent Bonhomme, Vincent Bonhomme, Charlotte Martial, Charlotte Martial, Olivia Gosseries, Olivia Gosseries, Steven Laureys, Steven Laureys, Steven Laureys, Aurore Thibaut, Aurore Thibaut   +17 more
doaj   +2 more sources

Drosophila as a Model to Study the Mechanism of Nociception

Frontiers in Physiology, 2022
Nociception refers to the process of encoding and processing noxious stimuli, which allow animals to detect and avoid potentially harmful stimuli. Several types of stimuli can trigger nociceptive sensory transduction, including thermal, noxious chemicals,
Jianzheng He, Jianzheng He, Jianzheng He, Botong Li, Botong Li, Shuzhen Han, Shuzhen Han, Yuan Zhang, Yuan Zhang, Kai Liu, Simeng Yi, Yongqi Liu, Yongqi Liu, Minghui Xiu, Minghui Xiu, Minghui Xiu   +15 more
doaj   +2 more sources

ATF4 selectively regulates heat nociception and contributes to kinesin-mediated TRPM3 trafficking

Nature Communications, 2021
The molecular mechanisms mediating nociception are unclear. Here, the authors show that the Activating Transcription Factor 4 (ATF4) is important for the response to heat nociception in mice and ATF4 role in mediating protein trafficking in dorsal root ...
Man-Xiu Xie, Xian-Ying Cao, Wei-An Zeng, Ren-Chun Lai, Lan Guo, Jun-Chao Wang, Yi-Bin Xiao, Xi Zhang, Di Chen, Xian-Guo Liu, Xiao-Long Zhang   +10 more
doaj   +2 more sources

Nociception monitors vs. standard practice for titration of opioid administration in general anesthesia: A meta-analysis of randomized controlled trials

Frontiers in Medicine, 2022
BackgroundNociception monitors are being increasingly used during surgery, but their effectiveness in guiding intraoperative opioid administration is still uncertain.
Dandan Ma, Dandan Ma, Jiahui Ma, Huayong Chen, Dongliang Mu, Hao Kong, Lingzhi Yu   +6 more
doaj   +2 more sources

A descending inhibitory mechanism of nociception mediated by an evolutionarily conserved neuropeptide system in Drosophila

eLife, 2023
Nociception is a neural process that animals have developed to avoid potentially tissue-damaging stimuli. While nociception is triggered in the peripheral nervous system, its modulation by the central nervous system is a critical process in mammals ...
Izumi Oikawa, Shu Kondo, Kao Hashimoto, Akiho Yoshida, Megumi Hamajima, Hiromu Tanimoto, Katsuo Furukubo-Tokunaga, Ken Honjo   +7 more
doaj   +2 more sources

Tools for analysis and conditional deletion of subsets of sensory neurons [version 1; peer review: 4 approved]

Wellcome Open Research, 2021
Background: Somatosensation depends on primary sensory neurons of the trigeminal and dorsal root ganglia (DRG). Transcriptional profiling of mouse DRG sensory neurons has defined at least 18 distinct neuronal cell types.
Ana P. Luiz, Federico Iseppon, James J. Cox, John N. Wood, Jing Zhao, Sonia Santana-Varela, Yury D. Bogdanov, Andrei L. Okorokov, Samuel J. Gossage, Larissa de Clauser, Shengnan Li, Jane E. Sexton, Marta Alves-Simoes   +12 more
doaj   +1 more source

Effect of nociception level index‐guided intra‐operative analgesia on early postoperative pain and opioid consumption: a systematic review and meta‐analysis

Anaesthesia, 2023
Acute postoperative pain remains a critical treatment priority and has prompted a search for technologies and techniques to assist with intra‐operative analgesic monitoring and management.
H. Bornemann-Cimenti, K. Lang-Illievich, K. Kovalevska, C. T. A. Brenna, C. Klivinyi   +4 more
semanticscholar   +1 more source

Guiding opioid-free intravenous antinociception with the Analgesia Nociception Index: a case report [PDF]

Revista Brasileira de Anestesiologia, 2021
Background: Opioid-free anesthesia decreases the incidence of opioid adverse events, but its optimal antinociceptive depth has not been clearly defined.
Sean Coeckelenbergh, Jean-Pierre Estebe
doaj   +3 more sources

TRPV1 feed-forward sensitisation depends on COX2 upregulation in primary sensory neurons

Scientific Reports, 2021
Increased activity and excitability (sensitisation) of a series of molecules including the transient receptor potential ion channel, vanilloid subfamily, member 1 (TRPV1) in pain-sensing (nociceptive) primary sensory neurons are pivotal for developing ...
Tianci Li, Gaoge Wang, Vivian Chin Chin Hui, Daniel Saad, Joao de Sousa Valente, Paolo La Montanara, Istvan Nagy   +6 more
doaj   +1 more source

In vivo antinociceptive and anti-inflammatory potential of hesperidin and its cyclodextrin inclusion compounds [PDF]

Balneo and PRM Research Journal, 2021
Introduction. This study aims to evaluate the antinociceptive activity on inflammatory and non-inflammatory nociception models, as well as the anti-inflammatory action of hesperidin and its inclusion compounds with beta-cyclodextrin and hydroxypropyl ...
CORCIOVĂ Andreia, IVĂNESCU Bianca, ABABEI Daniela Carmen, BURLEC Ana Flavia, MIRCEA Cornelia, BILD Veronica   +5 more
doaj   +1 more source