Results 1 to 10 of about 86,481 (293)

Assessment and management of pain/nociception in patients with disorders of consciousness or locked-in syndrome: A narrative review

Frontiers in Systems Neuroscience, 2023
The assessment and management of pain and nociception is very challenging in patients unable to communicate functionally such as patients with disorders of consciousness (DoC) or in locked-in syndrome (LIS).
Estelle A. C. Bonin, Estelle A. C. Bonin, Nicolas Lejeune, Nicolas Lejeune, Nicolas Lejeune, Emilie Szymkowicz, Emilie Szymkowicz, Vincent Bonhomme, Vincent Bonhomme, Charlotte Martial, Charlotte Martial, Olivia Gosseries, Olivia Gosseries, Steven Laureys, Steven Laureys, Steven Laureys, Aurore Thibaut, Aurore Thibaut   +17 more
doaj   +2 more sources

Drosophila as a Model to Study the Mechanism of Nociception

Frontiers in Physiology, 2022
Nociception refers to the process of encoding and processing noxious stimuli, which allow animals to detect and avoid potentially harmful stimuli. Several types of stimuli can trigger nociceptive sensory transduction, including thermal, noxious chemicals,
Jianzheng He, Jianzheng He, Jianzheng He, Botong Li, Botong Li, Shuzhen Han, Shuzhen Han, Yuan Zhang, Yuan Zhang, Kai Liu, Simeng Yi, Yongqi Liu, Yongqi Liu, Minghui Xiu, Minghui Xiu, Minghui Xiu   +15 more
doaj   +2 more sources

Nociception monitors vs. standard practice for titration of opioid administration in general anesthesia: A meta-analysis of randomized controlled trials

Frontiers in Medicine, 2022
BackgroundNociception monitors are being increasingly used during surgery, but their effectiveness in guiding intraoperative opioid administration is still uncertain.
Dandan Ma, Dandan Ma, Jiahui Ma, Huayong Chen, Dongliang Mu, Hao Kong, Lingzhi Yu   +6 more
doaj   +2 more sources

ATF4 selectively regulates heat nociception and contributes to kinesin-mediated TRPM3 trafficking

Nature Communications, 2021
The molecular mechanisms mediating nociception are unclear. Here, the authors show that the Activating Transcription Factor 4 (ATF4) is important for the response to heat nociception in mice and ATF4 role in mediating protein trafficking in dorsal root ...
Man-Xiu Xie, Xian-Ying Cao, Wei-An Zeng, Ren-Chun Lai, Lan Guo, Jun-Chao Wang, Yi-Bin Xiao, Xi Zhang, Di Chen, Xian-Guo Liu, Xiao-Long Zhang   +10 more
doaj   +2 more sources

Divergent modulation of nociception by glutamatergic and GABAergic neuronal subpopulations in the periaqueductal gray [PDF]

eNeuro, 2017
The ventrolateral periaqueductal gray (vlPAG) constitutes a major descending pain modulatory system and is a crucial site for opioid-induced analgesia. A number of previous studies have demonstrated that glutamate and GABA play critical opposing roles in
Bruchas, Michael R, Copits, Bryan A, Gereau, Robert W, IV, Gomez, Adrian M, Grajales-Reyes, Jose G, O\u27Brien, Daniel E, Samineni, Vijay K, Trigg, Sarah L   +7 more
core   +3 more sources

TRPV1 activity and substance P release are required for corneal cold nociception [PDF]

Nature Communications, 2019
As a protective mechanism, the cornea is sensitive to noxious stimuli. Here, we show that in mice, a high proportion of corneal TRPM8+ cold-sensing fibers express the heat-sensitive TRPV1 channel.
Guo, Changxiong, Hu, Hongzhen, Huang, Andrew J.W., Jiang, Haowu, Li, Fengxian, Liu, Qin, Yang, Weishan   +6 more
core   +3 more sources

Daily rhythm of nociception in rats

Journal of Circadian Rhythms, 2004
Background Many behavioral and physiological variables exhibit daily rhythmicity. Few investigations of the daily rhythmicity in nociception have been conducted, and conflicting results have been obtained.
Jayaprakash S, Vijaya C, Merlin NJ, Christina AJM, Murugesh N   +4 more
doaj   +2 more sources

A Multimodal Deep Learning Approach to Intraoperative Nociception Monitoring: Integrating Electroencephalogram, Photoplethysmography, and Electrocardiogram [PDF]

Sensors
Monitoring nociception under general anesthesia remains challenging due to the complexity of pain pathways and the limitations of single-parameter methods.
Omar M. T. Abdel Deen, Shou-Zen Fan, Jiann-Shing Shieh   +2 more
doaj   +2 more sources

Tools for analysis and conditional deletion of subsets of sensory neurons [version 1; peer review: 4 approved]

Wellcome Open Research, 2021
Background: Somatosensation depends on primary sensory neurons of the trigeminal and dorsal root ganglia (DRG). Transcriptional profiling of mouse DRG sensory neurons has defined at least 18 distinct neuronal cell types.
Ana P. Luiz, Federico Iseppon, James J. Cox, John N. Wood, Jing Zhao, Sonia Santana-Varela, Yury D. Bogdanov, Andrei L. Okorokov, Samuel J. Gossage, Larissa de Clauser, Shengnan Li, Jane E. Sexton, Marta Alves-Simoes   +12 more
doaj   +1 more source

Effect of nociception level index‐guided intra‐operative analgesia on early postoperative pain and opioid consumption: a systematic review and meta‐analysis

Anaesthesia, 2023
Acute postoperative pain remains a critical treatment priority and has prompted a search for technologies and techniques to assist with intra‐operative analgesic monitoring and management.
H. Bornemann-Cimenti, K. Lang-Illievich, K. Kovalevska, C. T. A. Brenna, C. Klivinyi   +4 more
semanticscholar   +1 more source