Results 1 to 10 of about 39,072 (265)
Frontiers in Systems Neuroscience, 2023 The assessment and management of pain and nociception is very challenging in patients unable to communicate functionally such as patients with disorders of consciousness (DoC) or in locked-in syndrome (LIS).
Estelle A. C. Bonin +17 more
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Optogenetics and photopharmacology in pain research and therapeutics
STEMedicine, 2020 Pain afflicts billions of people worldwide, who suffer especially from long-term chronic pain. This gruelling condition affects the nervous system at all levels: from the brain to the spinal cord, the Dorsal Root Ganglia (DRG) and the peripheral fibres ...
Federico Iseppon, Manuel Arcangeletti
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Drosophila as a Model to Study the Mechanism of Nociception
Frontiers in Physiology, 2022 Nociception refers to the process of encoding and processing noxious stimuli, which allow animals to detect and avoid potentially harmful stimuli. Several types of stimuli can trigger nociceptive sensory transduction, including thermal, noxious chemicals,
Jianzheng He +15 more
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The ankyrin repeat domain of the TRPA protein painless is important for thermal nociception but not mechanical nociception. [PDF]
PLoS ONE, 2012 The Drosophila TRPA channel Painless is required for the function of polymodal nociceptors which detect noxious heat and noxious mechanical stimuli. These functions of Painless are reminiscent of mammalian TRPA channels that have also been implicated in ...
Richard Y Hwang +2 more
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Wellcome Open Research, 2018 Background: Sensory neurons play an essential role in almost all pain conditions, and have recently been classified into distinct subsets on the basis of their transcriptomes. Here we have analysed alterations in dorsal root ganglia (DRG) gene expression
M.A. Bangash +17 more
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Leptin and fractalkine: novel subcutaneous cytokines in burn injury
Disease Models & Mechanisms, 2020 Burn injury is a pathology underpinned by progressive and aberrant inflammation. It is a major clinical challenge to survival and quality of life. Although the complex local and disseminating pathological processes of a burn injury ultimately stem from ...
Dominic Friston +7 more
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Pain without Nociceptors? Nav1.7-Independent Pain Mechanisms
Cell Reports, 2014 Nav1.7, a peripheral neuron voltage-gated sodium channel, is essential for pain and olfaction in mice and humans. We examined the role of Nav1.7 as well as Nav1.3, Nav1.8, and Nav1.9 in different mouse models of chronic pain.
Michael S. Minett +6 more
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Wellcome Open Research, 2018 Background: Functional deletion of the Scn9a (sodium voltage-gated channel alpha subunit 9) gene encoding sodium channel Nav1.7 makes humans and mice pain-free. Opioid signalling contributes to this analgesic state.
Vanessa Pereira +5 more
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Changes in Activity of the Same Thalamic Neurons to Repeated Nociception in Behaving Mice. [PDF]
PLoS ONE, 2015 The sensory thalamus has been reported to play a key role in central pain sensory modulation and processing, but its response to repeated nociception at thalamic level is not well known.
Yeowool Huh, Jeiwon Cho
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PLoS Neglected Tropical Diseases, 2023 Scorpion sting envenomations (SSE) are feared by the intense pain that they produce in victims. Pain from SSE is triggered mainly by the presence of neurotoxins in the scorpion venom that modulates voltage-gated ion channels.
Felipe Cerni +8 more
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