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A Multimodal Deep Learning Approach to Intraoperative Nociception Monitoring: Integrating Electroencephalogram, Photoplethysmography, and Electrocardiogram [PDF]
SensorsMonitoring nociception under general anesthesia remains challenging due to the complexity of pain pathways and the limitations of single-parameter methods.
Omar M. T. Abdel Deen +2 more
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Histone lactylation regulates DOCK4 to control heat nociception and supports Dynein-mediated Nav1.7 trafficking [PDF]
Nature CommunicationsHeat nociception involves thermosensors like transient receptor potential channel V1 in dorsal root ganglion (DRG) neurons, but their loss only partially impairs heat sensing, suggesting other mechanisms.
Man-Xiu Xie +12 more
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Daily rhythm of nociception in rats
Journal of Circadian Rhythms, 2004 Background Many behavioral and physiological variables exhibit daily rhythmicity. Few investigations of the daily rhythmicity in nociception have been conducted, and conflicting results have been obtained.
Jayaprakash S +4 more
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Animal Models of Nociception [PDF]
Pharmacological Reviews, 2001 The study of pain in awake animals raises ethical, philosophical, and technical problems. We review the ethical standards for studying pain in animals and emphasize that there are scientific as well as moral reasons for keeping to them. Philosophically, there is the problem that pain cannot be monitored directly in animals but can only be estimated by ...
Daniel Le Bars +2 more
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Wellcome Open Research, 2021 Background: Somatosensation depends on primary sensory neurons of the trigeminal and dorsal root ganglia (DRG). Transcriptional profiling of mouse DRG sensory neurons has defined at least 18 distinct neuronal cell types.
Ana P. Luiz +12 more
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Guiding opioid-free intravenous antinociception with the Analgesia Nociception Index: a case report [PDF]
Revista Brasileira de Anestesiologia, 2021 Background: Opioid-free anesthesia decreases the incidence of opioid adverse events, but its optimal antinociceptive depth has not been clearly defined.
Sean Coeckelenbergh, Jean-Pierre Estebe
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In vivo antinociceptive and anti-inflammatory potential of hesperidin and its cyclodextrin inclusion compounds [PDF]
Balneo and PRM Research Journal, 2021 Introduction. This study aims to evaluate the antinociceptive activity on inflammatory and non-inflammatory nociception models, as well as the anti-inflammatory action of hesperidin and its inclusion compounds with beta-cyclodextrin and hydroxypropyl ...
CORCIOVĂ Andreia +5 more
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TRPV1 feed-forward sensitisation depends on COX2 upregulation in primary sensory neurons
Scientific Reports, 2021 Increased activity and excitability (sensitisation) of a series of molecules including the transient receptor potential ion channel, vanilloid subfamily, member 1 (TRPV1) in pain-sensing (nociceptive) primary sensory neurons are pivotal for developing ...
Tianci Li +6 more
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Calcium imaging for analgesic drug discovery
Neurobiology of Pain, 2022 Somatosensation and pain are complex phenomena involving a rangeofspecialised cell types forming different circuits within the peripheral and central nervous systems.
Federico Iseppon +2 more
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eLife, 2023 Nociception is a neural process that animals have developed to avoid potentially tissue-damaging stimuli. While nociception is triggered in the peripheral nervous system, its modulation by the central nervous system is a critical process in mammals ...
Izumi Oikawa +7 more
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