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Drosophila as a Model to Study the Mechanism of Nociception [PDF]
Frontiers in Physiology, 2022 Nociception refers to the process of encoding and processing noxious stimuli, which allow animals to detect and avoid potentially harmful stimuli. Several types of stimuli can trigger nociceptive sensory transduction, including thermal, noxious chemicals,
Jianzheng He +15 more
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The ankyrin repeat domain of the TRPA protein painless is important for thermal nociception but not mechanical nociception. [PDF]
PLoS ONE, 2012 The Drosophila TRPA channel Painless is required for the function of polymodal nociceptors which detect noxious heat and noxious mechanical stimuli. These functions of Painless are reminiscent of mammalian TRPA channels that have also been implicated in ...
Richard Y Hwang +2 more
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INDEX OF ANALGESIA-NOCICEPTION: OPPORTUNITIES AND LIMITS
Вестник анестезиологии и реаниматологии, 2017 The review includes clinical opportunities of the new technique for evaluation balance of nociception/anti-nociception with help of medication of ANI-Monitor (MetroDoloris®, France), used abroad, with the calculation of original index of analgesia ...
A. P. Spasova +2 more
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Nociceptor-Enriched Genes Required for Normal Thermal Nociception
Cell Reports, 2016 Here, we describe a targeted reverse genetic screen for thermal nociception genes in Drosophila larvae. Using laser capture microdissection and microarray analyses of nociceptive and non-nociceptive neurons, we identified 275 nociceptor-enriched genes ...
Ken Honjo +4 more
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Daily rhythm of nociception in rats
Journal of Circadian Rhythms, 2004 Background Many behavioral and physiological variables exhibit daily rhythmicity. Few investigations of the daily rhythmicity in nociception have been conducted, and conflicting results have been obtained.
Jayaprakash S +4 more
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Analgesia Nociception Index for perioperative analgesia monitoring in spinal surgery
Revista Brasileira de Anestesiologia, 2016 Background and objectives: The Analgesia Nociception Index is an index used to measure the levels of pain, sympathetic system activity and heart rate variability during general anesthesia.
Guldem Turan +6 more
doaj +3 more sources
Ion Channels of Nociception [PDF]
International Journal of Molecular Sciences, 2020 The special issue “Ion Channels of Nociception” contains 13 articles published by 73 authors from different countries united by the main focusing on the peripheral mechanisms of pain. The content covers the mechanisms of neuropathic, inflammatory, and dental pain as well as pain in migraine and diabetes, nociceptive roles of P2X3, ASIC, Piezo and TRP ...
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TrpA1 regulates thermal nociception in Drosophila.
PLoS ONE, 2011 Pain is a significant medical concern and represents a major unmet clinical need. The ability to perceive and react to tissue-damaging stimuli is essential in order to maintain bodily integrity in the face of environmental danger.
G Gregory Neely +10 more
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Current Biology, 2017 Nociception, the sensory mechanism that allows animals to sense and avoid potentially tissue-damaging stimuli, is critical for survival. This process relies on nociceptors, which are specialized neurons that detect and respond to potentially damaging forms of energy - heat, mechanical and chemical - in the environment.
Nathan Risch +2 more
openaire +3 more sources
Wellcome Open Research, 2021 Background: Somatosensation depends on primary sensory neurons of the trigeminal and dorsal root ganglia (DRG). Transcriptional profiling of mouse DRG sensory neurons has defined at least 18 distinct neuronal cell types.
Ana P. Luiz +12 more
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