Results 101 to 110 of about 85,874 (280)
Models of Visceral Nociception [PDF]
ILAR Journal, 1999 Pains arising from the viscera constitute a large portion of clinically treated pains. They are characterized by poor localization; immobility with tonic increases in muscle tone; and vigorous but nonspecific changes in autonomic function, such as changes in respiration, heart rate, and blood pressure.
openaire +3 more sources
STING controls nociception via type I interferon signalling in sensory neurons
Nature, 2021 C. Donnelly +12 more
semanticscholar +1 more source
Advances in understanding nociception and neuropathic pain
Journal of Neurology, 2017 Pain results from the activation of a subset of sensory neurones termed nociceptors and has evolved as a “detect and protect” mechanism. However, lesion or disease in the sensory system can result in neuropathic pain, which serves no protective function.
Ewan St. John Smith
semanticscholar +1 more source
Scientific Reports, 2019 A pivotal role of the lateral hypothalamus (LH) in regulating appetitive and reward-related behaviors has been evident for decades. However, the contributions of LH circuits to other survival behaviors have been less explored. Here we examine how lateral
Justin N. Siemian +4 more
doaj +1 more source
Impaired pain sensation in mice lacking prokineticin 2
Molecular Pain, 2006 Prokineticins (PKs), consisting of PK1 and PK2, are a pair of newly identified regulatory peptides. Two closely related G-protein coupled receptors, PKR1 and PKR2, mediate the signaling of PKs. PKs/PKRs participate in the regulation of diverse biological
Amadesi Silvia +6 more
doaj +1 more source
Opioid regulation of Mu receptor internalisation: relevance to the development of tolerance and dependence [PDF]
, 2010 Internalisation of the mu opioid receptor from the surface of cells is generally achieved by receptor occupancy with agonist ligands of high efficacy. However, in many situations the potent analgesic morphine fails to promote internalisation effectively ...
Lopez-Gimenez, J.F., Milligan, G.
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The role of cGMP and PKG-I in spinal nociceptive processing [PDF]
, 2005 First paragraph (this article has no abstract) Persistent stimulation of nociceptors results in sensitization of nociceptive sensory neurons, which is associated with hyperalgesia and allodynia.
Geisslinger, Gerd +5 more
core +1 more source
Activated Microglia in Nociception
Pain Physician, 2010 Microglial cells appear to play a vital role in the initiation of certain neuropathic pain states. In order to initiate neuropathic pain, microglia need to be activated. Microglia activation in the spinal cord involves both hypertrophy as well as hyperplasia, progressing through a hypertrophic morphology, with thickened and retracted processes ...
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An assay for chemical nociception in Drosophila larvae
Philosophical Transactions of the Royal Society of London. Biological Sciences, 2019 Chemically induced nociception has not yet been studied intensively in genetically tractable models. Hence, our goal was to establish a Drosophila assay that can be used to study the cellular and molecular/genetic bases of chemically induced nociception.
R. Lopez-Bellido +4 more
semanticscholar +1 more source
TrpA1 regulates thermal nociception in Drosophila.
PLoS ONE, 2011 Pain is a significant medical concern and represents a major unmet clinical need. The ability to perceive and react to tissue-damaging stimuli is essential in order to maintain bodily integrity in the face of environmental danger.
G Gregory Neely +10 more
doaj +1 more source