Results 121 to 130 of about 14,156 (228)
The c‐Src inhibitor eCF506 diminishes opioid tolerance and reduces β‐arrestin2 recruitment
British Journal of Pharmacology, EarlyView.Morphine activation of μ receptors causes tolerance through c‐Src activation and β‐arrestin2 recruitment. c‐Src inhibition or degradation reduces β‐arrestin2 recruitment, μ receptor endocytosis, while causing receptor upregulation, all likely contributing to reduced morphine tolerance.
Samuel Singleton +6 more
wiley +1 more source
Research progress on functional brain network mechanisms of acupuncture intervention for migraine
针刺研究Migraine is a chronic neurological disorder involving multidimensional functional alterations of nociception， cognition， emotion and other domains. Abnormal changes in brain networks associated with sensation， cognition and emotion are closely linked to ...
Wei Hailin. Li Shujuan +3 more
doaj +2 more sources
The nociception coma scale: A new tool to assess nociception in disorders of consciousness.
, 2010 peer reviewedAssessing behavioral responses to nociception is difficult in severely brain-injured patients recovering from coma. We here propose a new scale developed for assessing nociception in vegetative (VS) and minimally conscious (MCS) coma ...
Demertzi, Athina +10 more
core +1 more source
TRPM3 regulates fear memory encoding and seizure susceptibility in the lateral amygdala
British Journal of Pharmacology, EarlyView.Abstract Background and purpose TRPM3 is best known for its role as a peripheral sensor of pain and heat. Recent studies reporting gain‐of‐function TRPM3 mutations in patients with neurodevelopmental and epilepsy‐associated disorders suggest a previously unrecognized role of this channel in the brain.
Attila Gyéresi +12 more
wiley +1 more source
Brain Research BulletinHere we assess whether neuropathic pain hypersensitivity is attenuated by spinal administration of the imidazoline I1-receptor agonist LNP599 and whether the attenuation involves co-activation of α2-adrenoceptors.
Hong Wei +5 more
doaj +1 more source
Equine Veterinary Education, EarlyView.Summary Background Adipose tissue‐derived mesenchymal stem cells (AT‐MSCs) are entering the market of orthobiologics suitable for managing musculoskeletal disorders in horses, due to their accessibility and reparative capacity. Ethical considerations in developing allogeneic products require a low‐morbidity approach to tissue harvest.
A. Nedergaard +2 more
wiley +1 more source
Basic and Clinical Neuroscience, 2020 Introduction: Broad neural circuits originate from the hypothalamic arcuate nucleus and project to many parts of the brain which are related to pain perception. Insulin receptors are found in the arcuate nucleus. Since nociception may be affected in type
Hossein Khaleghzadeh-Ahangar +4 more
doaj
The FEBS Journal, EarlyView.Using 1H NMR metabolomics, we measured polar and lipid metabolites from human blood neutrophils from people with frailty (n = 31, mean age 84Y), people with rheumatoid arthritis (n = 16, mean age 55Y), robust older (n = 24, mean age 66Y) and healthy younger people (n = 21, mean age 22Y).
Genna Ali Abdullah +5 more
wiley +1 more source
A lipid‐sensitive food choice behavior influences aging outcomes from a longevity‐promoting diet
The FEBS Journal, EarlyView.C. elegans are exposed to a variety of bacteria in their natural environment and must be able to distinguish between beneficial and detrimental food sources. We show that C. elegans exposed to the bacterium from their natural habitat, Methylobacterium, disrupts lipid homeostasis, causing worms to avoid this bacterial species and choose the laboratory ...
Nicole L. Stuhr +4 more
wiley +1 more source