Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain [PDF]
, 2017 Background: L-acetylcarnitine, a drug marketed for the treatment of chronic pain, causes analgesia by epigenetically up-regulating type-2 metabotropic glutamate (mGlu2) receptors in the spinal cord.
Battaglia, Giuseppe +10 more
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The Journal of Clinical Pharmacology, EarlyView.Abstract Autism spectrum disorders are characterized by some difficulties with social interactions and communication, atypical patterns of behavior, and unusual reactions to emotions. Studies have found promising results regarding the effects of cannabis on autism.
Rachel Riera +9 more
wiley +1 more source
Genetically‐targeted control of the spinal cord and peripheral nervous system
Journal of Intelligent Medicine, EarlyView.Application of genetically‐targeted stimulation for treating diseases or injuries outside the brain. Optogenetic and chemogenetic systems have been developed for dysfunction in the cochlea, spinal cord, dorsal root ganglia (DRGs), peripheral nerves, lower urinary tract, and enteric nervous system (ENS). Created with Biorender.com.
Anakaren Romero Lozano +3 more
wiley +1 more source
Somatosensory and nociceptive changes in chronic post-stroke shoulder pain [PDF]
, 2008 Preliminary results from a cross-sectional study that investigated the relation between the presence of post-stroke shoulder pain and somatosensory and nociceptive changes are presented.
Buitenweg, J.R. +5 more
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An Inversion Disrupting FAM134B Is Associated with Sensory Neuropathy in the Border Collie Dog Breed [PDF]
, 2016 Sensory neuropathy in the Border Collie is a severe neurological disorder caused by the degeneration of sensory and, to a lesser extent, motor nerve cells with clinical signs starting between 2 and 7 months of age.
Beltran, E +9 more
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The Role of Sinoaortic and Cardiopulmonary Baroreceptor Reflex Arcs in Nociception and Stress‐Induced Analgesiaa [PDF]
, 1986 Alan Randich, William Maixner
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Chronic sequelae and owner burdens are common following canine intervertebral disc disease
Veterinary Record, EarlyView.Abstract Background Canine intervertebral disc disease (IVDD) is common and may be managed conservatively or surgically. However, little is known about long‐term sequelae, quality of life and owners’ emotional burden after diagnosis. Methods Information regarding signalment, neuroanatomical lesion localisation, diagnostic imaging results and treatment ...
Frederik Samsøe‐Schmidt +2 more
wiley +1 more source
Transcriptional reprogramming post-peripheral nerve injury: A systematic review
Neurobiology of DiseaseNeuropathic pain is characterised by periodic or continuous hyperalgesia, numbness, or allodynia, and results from insults to the somatosensory nervous system.
R. Hayward +6 more
doaj
Systemic and Intra-Habenular Activation of the Orphan G Protein-Coupled Receptor GPR139 Decreases Compulsive-Like Alcohol Drinking and Hyperalgesia in Alcohol-Dependent Rats. [PDF]
, 2018 GPR139 is an orphan G protein-coupled receptor (GPCR) that is expressed mainly in the brain, with the highest expression in the medial habenula. The modulation of GPR139 receptor function has been hypothesized to be beneficial in the treatment of some ...
Conlisk, Dana +5 more
core
Effects of codeine, morphine and a novel opioid pentapeptide BW443C, on cough, nociception and ventilation in the unanaesthetized guinea‐pig [PDF]
, 1988 John J. Adcock, C. Schneider, T.W. Smith
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