Results 121 to 130 of about 86,806 (345)
STING controls nociception via type I interferon signalling in sensory neurons
Nature, 2021 C. Donnelly +12 more
semanticscholar +1 more source
Cutaneous nociception: Role of keratinocytes
Experimental Dermatology, 2019 Recent years have brought an enhanced understanding of keratinocyte contribution to cutaneous nociception. While intra‐epidermal nerve endings were classically considered as the exclusive transducers of cutaneous noxious stimuli, it has now been ...
M. Talagas +3 more
semanticscholar +1 more source
Intratumoral Nerve Phased Development: A Promising Therapeutic Target
Medicine Bulletin, EarlyView.ABSTRACT The nervous system has emerged as a critical regulator of tumor biology, engaging in dynamic crosstalk with cancer cells. Although the protumorigenic role of innervation is well established, increasing attention is now directed toward reciprocal influences—how tumors actively shape and remodel local nerve networks within the tumor ...
Xiangxian Che +3 more
wiley +1 more source
Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain [PDF]
, 2017 Background: L-acetylcarnitine, a drug marketed for the treatment of chronic pain, causes analgesia by epigenetically up-regulating type-2 metabotropic glutamate (mGlu2) receptors in the spinal cord.
Battaglia, Giuseppe +10 more
core +1 more source
Advanced Biomedical Research, 2016 Background: Stress can alter response to nociception. Under certain circumstances stress enhances nociception, a phenomenon which is called stress-induced hyperalgesia (SIH).
Masoud Nazeri +6 more
doaj +1 more source
Ion Channels Involved in Substance P-Mediated Nociception and Antinociception
International Journal of Molecular Sciences, 2019 Substance P (SP), an 11-amino-acid neuropeptide, has long been considered an effector of pain. However, accumulating studies have proposed a paradoxical role of SP in anti-nociception.
Chu-Ting Chang +2 more
semanticscholar +1 more source
Neurourology and Urodynamics, EarlyView.ABSTRACT Aims While many patients with lower urinary tract symptoms (LUTS) improve by treating peripheral causes, a substantial proportion continue to experience symptoms despite apparently successful interventions. Central nervous system (CNS) mechanisms could potentially contribute to persisting symptoms after the initial peripheral cause has been ...
Mathijs M. de Rijk +7 more
wiley +1 more source
Scientific Reports, 2019 A pivotal role of the lateral hypothalamus (LH) in regulating appetitive and reward-related behaviors has been evident for decades. However, the contributions of LH circuits to other survival behaviors have been less explored. Here we examine how lateral
Justin N. Siemian +4 more
doaj +1 more source
Advances in understanding nociception and neuropathic pain
Journal of Neurology, 2017 Pain results from the activation of a subset of sensory neurones termed nociceptors and has evolved as a “detect and protect” mechanism. However, lesion or disease in the sensory system can result in neuropathic pain, which serves no protective function.
Ewan St. John Smith
semanticscholar +1 more source
Veterinary Record, EarlyView.Background This study measured serum biomarkers at baseline and during an ovariohysterectomy in healthy female Spanish greyhounds, aiming to enhance the objectivity of current methods for assessing acute postoperative pain in dogs. Methods Blood samples from 20 Spanish greyhounds were collected before drug administration (T0‐baseline).
Rocio Navarrete‐Calvo +8 more
wiley +1 more source