Results 151 to 160 of about 2,763 (207)
British Journal of Pharmacology, Volume 183, Issue 16, Page 4512-4531, August 2026.The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
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European Journal of Dental Education, Volume 30, Issue 3, Page 907-914, August 2026.ABSTRACT Introduction The aim of this paper is to assess the prevalence, impact, and understanding of Lower Back Pain (LBP) amongst final year dental students to inform the development of a module in the dental curriculum. LBP has a significant impact on the dental workforce; yet little is reported about the profession's knowledge, or the necessity for
Samuel Cope +3 more
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European Journal of Neuroscience, Volume 64, Issue 3, August 2026.Pharmacological modulation of the R2 blink reflex was comparable whether responses were elicited using standard patch or concentric electrodes. Across nine studies, noradrenergic and GABAergic interventions produced the most consistent effects, supporting the R2 blink reflex as a sensitive biomarker of trigeminofacial nociceptive processing.
Josh Murphy +5 more
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Journal of Neurochemistry, Volume 170, Issue 8, August 2026.This work reviews how the metabolic by‐product methylglyoxal may contribute to the development of diabetic peripheral neuropathy (DPN), a common complication of diabetes characterized by nerve damage and chronic pain in the extremities. In diabetes, methylglyoxal levels rise due to increased glucose metabolism and reduced detoxification capacity. While
Gentry Totta‐Griese, Douglas E. Wright
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Journal of Small Animal Practice, Volume 67, Issue 8, Page 663-679, August 2026.Myxomatous mitral valve disease, an acquired valvular degeneration, is the most common cardiac disorder in dogs, affecting approximately 10% of dogs in primary care veterinary practice. Dogs with myxomatous mitral valve disease frequently require anaesthesia for routine procedures.
I. Levinzon +3 more
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Suicide and Life-Threatening Behavior, Volume 56, Issue 4, August 2026.ABSTRACT Introduction Non‐suicidal self‐injury (NSSI) is commonly understood as a behavior that serves to regulate affect, yet less is known about how specific emotional states relate to physical sensations during NSSI. This study examined whether high‐arousal negative emotions (HANEs) and low‐arousal negative emotions (LANEs) before NSSI were ...
Michelle K. Hiner +4 more
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Therapeutic potential of spexin in diabetic neuropathy: Insights from in vitro and in vivo models
Experimental Physiology, Volume 111, Issue 8, Page 3800-3817, 1 August 2026.Abstract The present study investigated the therapeutic potential of spexin (SPX) on both in vitro and in vivo models of diabetic neuropathy (DN). A total of 40 male BALB/c mice were randomly allocated into four experimental groups (n = 10 per group): a normoglycaemic control, an untreated DN group and two SPX treatment groups (DN+SPX‐12.5 and DN+SPX ...
Mehmet Refik Bahar +5 more
wiley +1 more source
Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 6475-6477, August 2026.
Jacopo Ciaffi +2 more
wiley +1 more source
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Revue Neurologique, 2021
Understanding intracranial nociceptive innervation is essential to understand the pathophysiology of headaches. Our knowledge about human intracranial nociception comes from sparse observations during neurosurgical procedures performed in awake patients, from human anatomical studies and from experimental studies in animals.
L.-M. Terrier, D. Fontaine
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Understanding intracranial nociceptive innervation is essential to understand the pathophysiology of headaches. Our knowledge about human intracranial nociception comes from sparse observations during neurosurgical procedures performed in awake patients, from human anatomical studies and from experimental studies in animals.
L.-M. Terrier, D. Fontaine
openaire +2 more sources
Monitoring the nociception–anti-nociception balance
Best Practice & Research Clinical Anaesthesiology, 2013At present, short-acting drugs are used in order to achieve the three components of anaesthesia, that is, analgesia, hypnosis and immobility. Assessment of the 'analgesia' component in daily clinical routine is, in contrast to the other components, still based on very unspecific clinical 'end' points such as movement, tearing, tachycardia or ...
Matthias, Gruenewald, Christoph, Ilies
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