Results 11 to 20 of about 87,919 (361)

Drosophila as a Model to Study the Mechanism of Nociception

Frontiers in Physiology, 2022
Nociception refers to the process of encoding and processing noxious stimuli, which allow animals to detect and avoid potentially harmful stimuli. Several types of stimuli can trigger nociceptive sensory transduction, including thermal, noxious chemicals,
Jianzheng He, Jianzheng He, Jianzheng He, Botong Li, Botong Li, Shuzhen Han, Shuzhen Han, Yuan Zhang, Yuan Zhang, Kai Liu, Simeng Yi, Yongqi Liu, Yongqi Liu, Minghui Xiu, Minghui Xiu, Minghui Xiu   +15 more
doaj   +2 more sources

ATF4 selectively regulates heat nociception and contributes to kinesin-mediated TRPM3 trafficking

Nature Communications, 2021
The molecular mechanisms mediating nociception are unclear. Here, the authors show that the Activating Transcription Factor 4 (ATF4) is important for the response to heat nociception in mice and ATF4 role in mediating protein trafficking in dorsal root ...
Man-Xiu Xie, Xian-Ying Cao, Wei-An Zeng, Ren-Chun Lai, Lan Guo, Jun-Chao Wang, Yi-Bin Xiao, Xi Zhang, Di Chen, Xian-Guo Liu, Xiao-Long Zhang   +10 more
doaj   +2 more sources

Nociception monitors vs. standard practice for titration of opioid administration in general anesthesia: A meta-analysis of randomized controlled trials

Frontiers in Medicine, 2022
BackgroundNociception monitors are being increasingly used during surgery, but their effectiveness in guiding intraoperative opioid administration is still uncertain.
Dandan Ma, Dandan Ma, Jiahui Ma, Huayong Chen, Dongliang Mu, Hao Kong, Lingzhi Yu   +6 more
doaj   +2 more sources

Divergent modulation of nociception by glutamatergic and GABAergic neuronal subpopulations in the periaqueductal gray [PDF]

eNeuro, 2017
The ventrolateral periaqueductal gray (vlPAG) constitutes a major descending pain modulatory system and is a crucial site for opioid-induced analgesia. A number of previous studies have demonstrated that glutamate and GABA play critical opposing roles in
Bruchas, Michael R, Copits, Bryan A, Gereau, Robert W, IV, Gomez, Adrian M, Grajales-Reyes, Jose G, O\u27Brien, Daniel E, Samineni, Vijay K, Trigg, Sarah L   +7 more
core   +3 more sources

Effect of nociception level index‐guided intra‐operative analgesia on early postoperative pain and opioid consumption: a systematic review and meta‐analysis

Anaesthesia, 2023
Acute postoperative pain remains a critical treatment priority and has prompted a search for technologies and techniques to assist with intra‐operative analgesic monitoring and management.
H. Bornemann-Cimenti, K. Lang-Illievich, K. Kovalevska, C. T. A. Brenna, C. Klivinyi   +4 more
semanticscholar   +1 more source

From nociception in aneural animals to human suffering: toward a comparative biology of pain. [PDF]

J Exp Biol
Walters ET.
europepmc   +3 more sources

Intraoperative Assessment of Surgical Stress Response Using Nociception Monitor under General Anesthesia and Postoperative Complications: A Narrative Review

Journal of Clinical Medicine, 2022
We present a narrative review focusing on the new role of nociception monitor in intraoperative anesthetic management. Higher invasiveness of surgery elicits a higher degree of surgical stress responses including neuroendocrine-metabolic and inflammatory-
Munetaka Hirose, H. Okutani, Kazuma Hashimoto, R. Ueki, N. Shimode, N. Kariya, Yumiko Takao, T. Tatara   +7 more
semanticscholar   +1 more source

Reduced postoperative pain in patients receiving nociception monitor guided analgesia during elective major abdominal surgery: a randomized, controlled trial

Journal of clinical monitoring and computing, 2022
The Nociception Level index (NOL™) is a multiparameter index, based on artificial intelligence for the monitoring of nociception during anesthesia. We studied the influence of NOL-guided analgesia on postoperative pain scores in patients undergoing major
Rivka Fuica, Carlos Krochek, R. Weissbrod, Dimitri Greenman, Andres Freundlich, Y. Gozal   +5 more
semanticscholar   +1 more source

Analgesia nociception index and high frequency variability index: promising indicators of relative parasympathetic tone

Journal of Anesthesia, 2022
At present, there is no objective and absolute measure of nociception, although various monitoring techniques have been developed. One such technique is the Analgesia Nociception Index (ANI), which is calculated from heart rate variability that reflects ...
Keisuke Yoshida, Shinju Obara, Satoki Inoue   +2 more
semanticscholar   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source