Results 11 to 20 of about 86,806 (345)

Ion Channels of Nociception [PDF]

International Journal of Molecular Sciences, 2020
The special issue “Ion Channels of Nociception” contains 13 articles published by 73 authors from different countries united by the main focusing on the peripheral mechanisms of pain.
Rashid Giniatullin
semanticscholar   +3 more sources

Divergent Modulation of Nociception by Glutamatergic and GABAergic Neuronal Subpopulations in the Periaqueductal Gray [PDF]

eNeuro, 2017
The ventrolateral periaqueductal gray (vlPAG) constitutes a major descending pain modulatory system and is a crucial site for opioid-induced analgesia. A number of previous studies have demonstrated that glutamate and GABA play critical opposing roles in
V. Samineni, J. Grajales-Reyes, B. Copits, Daniel E. O'Brien, Sarah L Trigg, A. Gomez, M. Bruchas, R. Gereau   +7 more
semanticscholar   +4 more sources

TRPV1 activity and substance P release are required for corneal cold nociception [PDF]

Nature Communications, 2019
As a protective mechanism, the cornea is sensitive to noxious stimuli. Here, we show that in mice, a high proportion of corneal TRPM8+ cold-sensing fibers express the heat-sensitive TRPV1 channel.
Fengxian Li, Weishan Yang, Haowu Jiang, Changxiong J. Guo, A. Huang, Hongzhen Hu, Qin Liu   +6 more
semanticscholar   +3 more sources

Nociception [PDF]

Current Biology, 2017
Nociception, the sensory mechanism that allows animals to sense and avoid potentially tissue-damaging stimuli, is critical for survival. This process relies on nociceptors, which are specialized neurons that detect and respond to potentially damaging forms of energy - heat, mechanical and chemical - in the environment.
Nathan Risch, François Pointeau, Nolwenn Poquet   +2 more
openaire   +3 more sources

Role of NHE1 in Nociception [PDF]

Pain Research and Treatment, 2013
Intracellular pH is a fundamental parameter to cell function that requires tight homeostasis. In the absence of any regulation, excessive acidification of the cytosol would have the tendency to produce cellular damage. Mammalian Na+/H+exchangers (NHEs) are electroneutral Na+-dependent proteins that exchange extracellular Na+for intracellular H+.
Jorge E. Torres‐López, Crystell Guadalupe Guzmán‐Priego, Héctor Isaac Rocha‐González, Vinicio Granados‐Soto   +3 more
openalex   +4 more sources

Nociception, Pain, Negative Moods, and Behavior Selection [PDF]

Neuron, 2015
Marwan N. Baliki, A. Vania Apkarian
openalex   +2 more sources

Calcium imaging for analgesic drug discovery

Neurobiology of Pain, 2022
Somatosensation and pain are complex phenomena involving a rangeofspecialised cell types forming different circuits within the peripheral and central nervous systems.
Federico Iseppon, John E. Linley, John N. Wood   +2 more
doaj   +1 more source

Different perspectives for monitoring nociception during general anesthesia

Korean Journal of Anesthesiology, 2022
Safe anesthesia is achieved using objective methods that estimate the patient’s state during different phases of surgery. A patient’s state under anesthesia is characterized by three major aspects, which are linked to the main effects produced by each of
Pablo Martinez-Vazquez, E. Jensen
semanticscholar   +1 more source

Cardiac Nociception [PDF]

Circulation, 2006
Mechanisms underlying cardiac pain are of major importance in cardiovascular medicine. In this review we address a fundamental clinical and experimental aspect. In particular neural circuitry involved justify a stepwise involvement of central structures responsible of reflex adjustments initiated by peripheral ischemia that can be associated with pain ...
P. G. Camici, M. Pagani
openaire   +2 more sources

Application of the Analgesia Nociception Index and Visual Analog Scale to Assess Pain During Hysteroscopy Under Local Anesthesia. [PDF]

J Clin Med
Nowak A, Chmaj-Wierzchowska K, Malinger A, Wilczak M.   +3 more
europepmc   +3 more sources