Results 21 to 30 of about 39,072 (265)

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Distinct nociception processing in the dysgranular and barrel regions of the mouse somatosensory cortex

Nature Communications, 2022
The processing of nociception in the somatosensory cortex (S1) has yet to be fully understood. Here, the authors demonstrate that the dysgranular region in S1 has an affinity for nociception and is critically involved in pain-like behavior.
Hironobu Osaki, Moeko Kanaya, Yoshifumi Ueta, Mariko Miyata   +3 more
doaj   +1 more source

ATF4 selectively regulates heat nociception and contributes to kinesin-mediated TRPM3 trafficking

Nature Communications, 2021
The molecular mechanisms mediating nociception are unclear. Here, the authors show that the Activating Transcription Factor 4 (ATF4) is important for the response to heat nociception in mice and ATF4 role in mediating protein trafficking in dorsal root ...
Man-Xiu Xie, Xian-Ying Cao, Wei-An Zeng, Ren-Chun Lai, Lan Guo, Jun-Chao Wang, Yi-Bin Xiao, Xi Zhang, Di Chen, Xian-Guo Liu, Xiao-Long Zhang   +10 more
doaj   +1 more source

INDEX OF ANALGESIA-NOCICEPTION: OPPORTUNITIES AND LIMITS

Вестник анестезиологии и реаниматологии, 2017
The review includes clinical opportunities of the new technique for evaluation balance of nociception/anti-nociception with help of medication of ANI-Monitor (MetroDoloris®, France), used abroad, with the calculation of original index of analgesia ...
A. P. Spasova, G. P. Tikhova, R. O. Bazarov   +2 more
doaj   +1 more source

Do decapod crustaceans have nociceptors for extreme pH? [PDF]

PLoS ONE, 2010
Nociception is the physiological detection of noxious stimuli. Because of its obvious importance, nociception is expected to be widespread across animal taxa and to trigger robust behaviours reliably. Nociception in invertebrates, such as crustaceans, is
Sakshi Puri, Zen Faulkes
doaj   +1 more source

The validity and applications of the analgesia nociception index: a narrative review

Frontiers in Surgery, 2023
Pain refers to the subjective, unpleasant experience that is related to illness or injury. In contrast to pain, nociception refers to the physiological neural processing of noxious stimuli, such as intra-operative surgical stimuli.
Bill Hum, Alexa Christophides, Zhaosheng Jin, Murad Elias, Kamil Taneja, Sergio D. Bergese   +5 more
doaj   +1 more source

Analgesic targets identified in mouse sensory neuron somata and terminal pain translatomes

Cell Reports
Summary: The relationship between transcription and protein expression is complex. We identified polysome-associated RNA transcripts in the somata and central terminals of mouse sensory neurons in control, painful (plus nerve growth factor), and pain ...
M. Ali Bangash, Cankut Cubuk, Federico Iseppon, Rayan Haroun, Chloe Garcia, Ana P. Luiz, Manuel Arcangeletti, Samuel J. Gossage, Sonia Santana-Varela, James J. Cox, Myles J. Lewis, John N. Wood, Jing Zhao   +12 more
doaj   +1 more source

Mitogen- and stress-activated kinase 1 in primary sensory neurons contributes to formalin-induced tonic pain

PAIN Reports
. Introduction:. The nuclear mitogen- and stress-activated kinases (MSKs) play a critical role in the development and persistence of pain after tissue injury. Objectives:. Here, we ascertained the MSK isoform, the cells and mechanisms, which mediate MSKs'
Jahanzaib Irfan, Rizki M. Febrianto, Paolo La Montanara, Michelle Y Meng, Thomas H. Hutson, David Zimmermann, Krisztina Deak-Pocsai, Deemah Aldossary, Jianglin Wang, Simone Di Giovanni, Michaela Kress, Istvan Nagy   +11 more
doaj   +1 more source

Mechanisms involved in the nociception triggered by the venom of the armed spider Phoneutria nigriventer.

PLoS Neglected Tropical Diseases, 2013
BackgroundThe frequency of accidental spider bites in Brazil is growing, and poisoning due to bites from the spider genus Phoneutria nigriventer is the second most frequent source of such accidents.
Camila Gewehr, Sara Marchesan Oliveira, Mateus Fortes Rossato, Gabriela Trevisan, Gerusa Duarte Dalmolin, Flávia Karine Rigo, Célio José de Castro Júnior, Marta Nascimento Cordeiro, Juliano Ferreira, Marcus V Gomez   +9 more
doaj   +1 more source

Visceral nociception

Current Review of Pain, 2000
Visceral pain is of great concern to the medical community because it remains particularly resistant to current clinical treatments. A serendipitous and initially unexplainable clinical finding that a punctate midline dorsal column lesion is effective in eliminating visceral pain, however, has initiated a resurgence of interest in the study of the ...
openaire   +3 more sources