Results 21 to 30 of about 87,919 (361)
Nociception and pain in humans lacking a functional TRPV1 channel
Journal of Clinical Investigation, 2022 BACKGROUND Chronic pain is a debilitating illness with currently limited therapy, in part due to difficulties in translating treatments derived from animal models to patients.
Ben Katz +12 more
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International Journal of Molecular Sciences, 2020 The special issue “Ion Channels of Nociception” contains 13 articles published by 73 authors from different countries united by the main focusing on the peripheral mechanisms of pain.
Rashid Giniatullin
semanticscholar +1 more source
Different perspectives for monitoring nociception during general anesthesia
Korean Journal of Anesthesiology, 2022 Safe anesthesia is achieved using objective methods that estimate the patient’s state during different phases of surgery. A patient’s state under anesthesia is characterized by three major aspects, which are linked to the main effects produced by each of
Pablo Martinez-Vazquez, E. Jensen
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Optogenetics and photopharmacology in pain research and therapeutics
STEMedicine, 2020 Pain afflicts billions of people worldwide, who suffer especially from long-term chronic pain. This gruelling condition affects the nervous system at all levels: from the brain to the spinal cord, the Dorsal Root Ganglia (DRG) and the peripheral fibres ...
Federico Iseppon, Manuel Arcangeletti
doaj +1 more source
Pathophysiology, 2022 Pain and nociception are different phenomena. Nociception is the result of complex activity in sensory pathways. On the other hand, pain is the effect of interactions between nociceptive processes, and cognition, emotions, as well as the social context ...
M. Cascella +6 more
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The ankyrin repeat domain of the TRPA protein painless is important for thermal nociception but not mechanical nociception. [PDF]
PLoS ONE, 2012 The Drosophila TRPA channel Painless is required for the function of polymodal nociceptors which detect noxious heat and noxious mechanical stimuli. These functions of Painless are reminiscent of mammalian TRPA channels that have also been implicated in ...
Richard Y Hwang +2 more
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Descending control of nociception in insects?
Proceedings of the Royal Society B, 2022 Modulation of nociception allows animals to optimize chances of survival by adapting their behaviour in different contexts. In mammals, this is executed by neurons from the brain and is referred to as the descending control of nociception.
M. Gibbons, Sajedeh Sarlak, L. Chittka
semanticscholar +1 more source
Wellcome Open Research, 2018 Background: Sensory neurons play an essential role in almost all pain conditions, and have recently been classified into distinct subsets on the basis of their transcriptomes. Here we have analysed alterations in dorsal root ganglia (DRG) gene expression
M.A. Bangash +17 more
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Leptin and fractalkine: novel subcutaneous cytokines in burn injury
Disease Models & Mechanisms, 2020 Burn injury is a pathology underpinned by progressive and aberrant inflammation. It is a major clinical challenge to survival and quality of life. Although the complex local and disseminating pathological processes of a burn injury ultimately stem from ...
Dominic Friston +7 more
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Myristic acid reduces skin inflammation and nociception.
Journal of food biochemistry, 2021 This study evaluated the inhibitory effect of myristic acid (MA) on models of inflammation and nociception. The in vitro anti-inflammatory activities of MA were assessed on LPS-stimulated macrophages, membrane stabilization assay, and inhibition of ...
Á. Alonso-Castro +4 more
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