Comparison of the qCON and qNOX indices for the assessment of unconsciousness level and noxious stimulation response during surgery [PDF]
, 2016 The objective of this work is to compare the performances of two electroencephalogram based indices for detecting loss of consciousness and loss of response to nociceptive stimulation.
Agustí, Mercé +8 more
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A novel multivariate STeady-state index during general ANesthesia (STAN) [PDF]
, 2017 The assessment of the adequacy of general anesthesia for surgery, namely the nociception/anti-nociception balance, has received wide attention from the scientific community. Monitoring systems based on the frontal EEG/EMG, or autonomic state reactions (e.
A Albertin +34 more
core +1 more source
Role of NHE1 in Nociception [PDF]
Pain Research and Treatment, 2013 Intracellular pH is a fundamental parameter to cell function that requires tight homeostasis. In the absence of any regulation, excessive acidification of the cytosol would have the tendency to produce cellular damage. Mammalian Na+/H+exchangers (NHEs) are electroneutral Na+-dependent proteins that exchange extracellular Na+for intracellular H+.
Jorge Elías Torres-López +3 more
openaire +3 more sources
Pain without Nociceptors? Nav1.7-Independent Pain Mechanisms
Cell Reports, 2014 Nav1.7, a peripheral neuron voltage-gated sodium channel, is essential for pain and olfaction in mice and humans. We examined the role of Nav1.7 as well as Nav1.3, Nav1.8, and Nav1.9 in different mouse models of chronic pain.
Michael S. Minett +6 more
doaj +1 more source
Comparison of clinical signs and outcomes between dogs with presumptive ischemic myelopathy and dogs with acute non compressive nucleus pulposus extrusion [PDF]
, 2016 OBJECTIVE To compare clinical signs and outcomes between dogs with presumptive ischemic myelopathy and dogs with presumptive acute noncompressive nucleus pulposus extrusion (ANNPE). DESIGN Retrospective study. ANIMALS 51 dogs with ischemic myelopathy and
De Decker, S +3 more
core +3 more sources
Nociception and the neonatal brain [PDF]
Seminars in Fetal and Neonatal Medicine, 2019 Measuring brain activity in infants provides an objective surrogate approach with which to infer pain perception following noxious events. Here we discuss different approaches which can be used to measure noxious-evoked brain activity, and discuss how these measures can be used to assess the analgesic efficacy of pharmacological and non-pharmacological
Deniz Gursul +2 more
openaire +3 more sources
Wellcome Open Research, 2018 Background: Functional deletion of the Scn9a (sodium voltage-gated channel alpha subunit 9) gene encoding sodium channel Nav1.7 makes humans and mice pain-free. Opioid signalling contributes to this analgesic state.
Vanessa Pereira +5 more
doaj +1 more source
Conditional gene deletion reveals functional redundancy of GABAB receptors in peripheral nociceptors in vivo [PDF]
, 2009 Background Gamma-aminobutyric acid (GABA) is an important inhibitory neurotransmitter which mainly mediates its effects on neurons via ionotropic (GABAA) and metabotropic (GABAB) receptors.
Bernhard Bettler +9 more
core +3 more sources
Quantification of the influence of drugs on zebrafish larvae swimming kinematics and energetics [PDF]
, 2020 The use of zebrafish larvae has aroused wide interest in the medical field for its potential role in the development of new therapies. The larvae grow extremely quickly and the embryos are nearly transparent which allows easy examination of its internal ...
Jiang, Hui-Rong +13 more
core +2 more sources
Changes in Activity of the Same Thalamic Neurons to Repeated Nociception in Behaving Mice. [PDF]
PLoS ONE, 2015 The sensory thalamus has been reported to play a key role in central pain sensory modulation and processing, but its response to repeated nociception at thalamic level is not well known.
Yeowool Huh, Jeiwon Cho
doaj +1 more source