Results 61 to 70 of about 39,072 (265)

5-HT3-Receptor Antagonist Inhibits Visceral Pain Differently in Chemical and Mechanical Stimuli in Rats

Journal of Pharmacological Sciences, 2004
The present study was designed to compare the effects of a selective 5-HT3-receptor antagonist, alosetron, on the glycerol- and colorectal distention (CRD)-induced visceral nociception as measured by changes in EMG of the external oblique muscle in ...
Tomohisa Mori, Ken-ichi Kawano, Takashi Shishikura   +2 more
doaj   +1 more source

Testing the Role of Glutamate NMDA Receptors in Peripheral Trigeminal Nociception Implicated in Migraine Pain [PDF]

, 2022
Cindy Guerrero-Toro, Kseniia Koroleva, Elizaveta V. Ermakova, Oleg Gafurov, П. А. Абушик, Pasi Tavi, Г. Ф. Ситдикова, Rashid Giniatullin   +7 more
openalex   +1 more source

Impaired pain sensation in mice lacking prokineticin 2

Molecular Pain, 2006
Prokineticins (PKs), consisting of PK1 and PK2, are a pair of newly identified regulatory peptides. Two closely related G-protein coupled receptors, PKR1 and PKR2, mediate the signaling of PKs. PKs/PKRs participate in the regulation of diverse biological
Amadesi Silvia, Luo Z David, Li Jia-Da, Zhang Chengkang, Hu Wang-Ping, Bunnett Nigel, Zhou Qun-Yong   +6 more
doaj   +1 more source

Parabrachial Nucleus Activity in Nociception and Pain in Awake Mice [PDF]

, 2023
Jesse A. Smith, Yadong Ji, Rebecca M. Lorsung, Macauley Smith Breault, Jeffrey A. Koenig, Nathan Cramer, Radi Masri, Asaf Keller   +7 more
openalex   +1 more source

Research progress on the depth of anesthesia monitoring based on the electroencephalogram

Ibrain, Volume 11, Issue 1, Page 32-43, Spring 2025.
Electroencephalogram (EEG) can noninvasive, continuous, and real‐time monitor the state of brain electrical activity, and the monitoring of EEG can reflect changes in the depth of anesthesia (DOA). The development of artificial intelligence can enable anesthesiologists to extract, analyze, and quantify DOA from complex EEG data.
Xiaolan He, Tingting Li, Xiao Wang
wiley   +1 more source

Things We Do for No Reason™: Prescribing gabapentinoids for pain

Journal of Hospital Medicine, EarlyView.
Abstract Gabapentin and pregabalin are among the most frequently prescribed medications in the United States, with gabapentin in the top 10 and pregabalin in the top 100. Despite FDA approval for only select neuropathic conditions, most use is for off‐label pain indications.
Niti G. Patel, David Goese, Steven M. Belknap, Charles L. Madeira, Jeffrey H. Barsuk   +4 more
wiley   +1 more source

Methods Used to Evaluate Pain Behaviors in Rodents

Frontiers in Molecular Neuroscience, 2017
Rodents are commonly used to study the pathophysiological mechanisms of pain as studies in humans may be difficult to perform and ethically limited.
Jennifer R. Deuis, Lucie S. Dvorakova, Irina Vetter, Irina Vetter   +3 more
doaj   +1 more source

Spinal Excitatory Dynorphinergic Interneurons Contribute to Burn Injury-Induced Nociception Mediated by Phosphorylated Histone 3 at Serine 10 in Rodents [PDF]

, 2021
Angelika Varga, Zoltán Mészár, Miklós Sivadó, Tímea Bácskai, Bence Végh, Éva Kókai, I. Nagy, Péter Szűcs   +7 more
openalex   +1 more source

Traditional Chinese Medicine as an Integrative Adjunct in Oncology Perioperative Practice: Analgesia, Immune Modulation, and Translational Challenges

Medicine Bulletin, EarlyView.
ABSTRACT Traditional Chinese medicine (TCM), including herbal analgesic adjuvants and acupuncture‐based interventions, has gained increasing attention as an integrative strategy for perioperative pain management in oncology. Bioactive phytochemicals—such as terpenoids, flavonoids, alkaloids, and polyphenols—exert multimodal pharmacological effects ...
Yuqin Tang, Zheng Luo, Xu Zhao, Yongqiang Zhang, Mingyang Sun, Jiaqiang Zhang   +5 more
wiley   +1 more source

Antinociceptive activity of the ethanolic extract, fractions, and aggregatin D isolated from Sinningia aggregata tubers.

PLoS ONE, 2015
The present study investigated the effects of the ethanolic extract (ESa), fractions, and compounds isolated from Sinningia aggregata in male Swiss mice on carrageenan-induced paw edema, neutrophil migration, mechanical hyperalgesia, formalin-induced ...
Geórgea V Souza, Alex S Simas, Amanda L Bastos-Pereira, Gisele R A Frois, João L C Ribas, Maria H Verdan, Cândida A L Kassuya, Maria E Stefanello, Aleksander R Zampronio   +8 more
doaj   +1 more source