Results 61 to 70 of about 85,874 (280)
The Neurobiology of Nociceptive and Anti-nociceptive Systems
Pain Physician, 2005 Pain is both a sensory event of the peripheral and central nervous systems and an experience that arises from, and reciprocally can affect processes of higher consciousness. Alterations in peripheral and central neuraxes can lead to sensitization, structural modification and long-term potentiation that can overcome modulatory influence(s) and change ...
openaire +2 more sources
Lifting the veil on the keratinocyte contribution to cutaneous nociception
Protein & Cell, 2020 Cutaneous nociception is essential to prevent individuals from sustaining injuries. According to the conventional point of view, the responses to noxious stimuli are thought to be exclusively initiated by sensory neurons, whose activity would be at most ...
M. Talagas +3 more
semanticscholar +1 more source
Nociceptor-Enriched Genes Required for Normal Thermal Nociception
Cell Reports, 2016 Here, we describe a targeted reverse genetic screen for thermal nociception genes in Drosophila larvae. Using laser capture microdissection and microarray analyses of nociceptive and non-nociceptive neurons, we identified 275 nociceptor-enriched genes ...
Ken Honjo +4 more
doaj +1 more source
Genetic study in patients operated dentally and anesthetized with articaine-epinephrine [PDF]
, 2019 Aims: In this study we wanted to figure out if there was a correlation between OPRM1 N40D, TRPV1 I316M, TRPV1 I585V, NOS3 −786T>C and IL6 −174C>G polymorphisms and the response to locally applied articaine-epinephrine anesthetic.
Cieza-Borrella, C +5 more
core +2 more sources
PAIN Reports. Introduction:. The nuclear mitogen- and stress-activated kinases (MSKs) play a critical role in the development and persistence of pain after tissue injury. Objectives:. Here, we ascertained the MSK isoform, the cells and mechanisms, which mediate MSKs'
Jahanzaib Irfan +11 more
doaj +1 more source
, 2017 Pain is an integrative phenomenon that results from dynamic interactions between sensory and contextual (i.e., cognitive, emotional, and motivational) processes.
Gross, Joachim +2 more
core +1 more source
Nature Communications, 2019 In humans, gamma-band oscillations in the primary somatosensory cortex (S1) correlate with subjective pain perception. However, functional contributions to pain and the nature of underlying circuits are unclear.
L. L. Tan +6 more
semanticscholar +1 more source
TRP Channel Cooperation for Nociception: Therapeutic Opportunities.
Annual Review of Pharmacology and Toxicology, 2020 Chronic pain treatment remains a sore challenge, and in our aging society, the number of patients reporting inadequate pain relief continues to grow. Current treatment options all have their drawbacks, including limited efficacy and the propensity of ...
Dorien Bamps +3 more
semanticscholar +1 more source
Analgesia Nociception Index: assessment of acute postoperative pain [PDF]
Revista Brasileira de AnestesiologiaBackground and objectives Patient self-rating based scales such as Numerical Rating Scale, Visual Analog Scale that is used for postoperative pain assessment may be problematic in geriatric or critically ill patients with communication problems. A method
Ruslan Abdullayev +2 more
doaj +3 more sources
In vitro and in vivo pharmacological activities of 14-o-phenylpropyloxymorphone, a potent mixed mu/delta/kappa-opioid receptor agonist with reduced constipation in mice [PDF]
, 2018 Pain, particularly chronic pain, is still an unsolved medical condition. Central goals in pain control are to provide analgesia of adequate efficacy and to reduce complications associated with the currently available drugs.
Lattanzi, Roberta +4 more
core +2 more sources