BMP signaling downstream of the Highwire E3 ligase sensitizes nociceptors. [PDF]
PLoS Genetics, 2018 A comprehensive understanding of the molecular machinery important for nociception is essential to improving the treatment of pain. Here, we show that the BMP signaling pathway regulates nociception downstream of the E3 ubiquitin ligase highwire (hiw ...
Ken Honjo, W Daniel Tracey
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Intense isolectin-B4 binding in rat dorsal root ganglion neurons distinguishes c-fiber nociceptors with broad action potentials and high nav1.9 expression [PDF]
, 2006 Binding to isolectin-B4 (IB4) and expression of tyrosine kinase A (trkA) (the high-affinity NGF receptor) have been used to define two different subgroups of nociceptive small dorsal root ganglion (DRG) neurons. We previously showed that only nociceptors
Berry, Carol +6 more
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Cutaneous inflammation alters nociceptor electrophysiology in guinea pigs but not rats [PDF]
Biomolecules & BiomedicineInflammatory pain hypersensitivity is believed to result, in part, from increased excitability of nociceptive dorsal root ganglion (DRG) neurons. We previously demonstrated in guinea pigs that hindlimb inflammation induces electrophysiological changes ...
Laiche Djouhri +7 more
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Pain perception in schizophrenia: A neglected phenomenon with a great impact
European Psychiatry, 2021 Introduction A decrease in pain sensitivity has been observed in patients with schizophrenia since the beginning of the twentieth century. This hypothesis further emerged during the last decades due to many clinical findings. Objectives To study pain
N. Faouel +4 more
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Participation of Potential Transient Receptors in the Antinociceptive Effect of Pharmacopuncture
Journal of Acupuncture & Meridian Studies, 2022 Background : Despite the widespread clinical use of acupuncture in painful situations, the use of this treatment should be further clarified. Nociception is mediated by the activation of nociceptors, such as transient receptor potentials (TRPs).
Isabella de Paula Ribeiro Argôlo +3 more
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TTX-Resistant Sodium Channels Functionally Separate Silent From Polymodal C-nociceptors
Frontiers in Cellular Neuroscience, 2020 Pronounced activity-dependent slowing of conduction has been used to characterize mechano-insensitive, “silent” nociceptors and might be due to high expression of NaV1.8 and could, therefore, be characterized by their tetrodotoxin-resistance (TTX-r ...
Robin Jonas +10 more
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Nociceptive Sensory Neurons Mediate Inflammation Induced by Bacillus Anthracis Edema Toxin
Frontiers in Immunology, 2021 Bacterial products are able to act on nociceptive neurons during pathogenic infection. Neurogenic inflammation is an active part of pain signaling and has recently been shown to impact host-pathogen defense.
Nicole J. Yang +7 more
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GTL-1, a Calcium Activated TRPM Channel, Enhances Nociception
Frontiers in Pharmacology, 2020 C. elegans PVD neurons are conserved for morphology, function and molecular determinants with mammalian polymodal nociceptors. Functions of polymodal nociceptors require activities of multiple ion channels and receptors including members of the TRP ...
Emiliano Cohen +4 more
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Cellular and Molecular Mechanisms Underlying Pain Chronicity
Cells, 2023 Chronic pain affects a significant amount of the population and is responsible for vast worldwide socio-economic costs [...]
Manuela Simonetti, Daniela Mauceri
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Life, 2022 In recent years, extracorporeal shock wave therapy (ESWT) has received increasing attention for its potential beneficial effects on various bone and soft-tissue pathologies, yielding promising outcomes for pain relief and functional recovery.
Larisa Ryskalin +4 more
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