Results 91 to 100 of about 49,496 (354)
Cephalalgia, 2019 Background Botulinum neurotoxin type A, an FDA-approved prophylactic drug for chronic migraine, is thought to achieve its therapeutic effect through blocking activation of unmyelinated meningeal nociceptors and their downstream communications with ...
A. Melo-Carrillo +7 more
semanticscholar +1 more source
Journal of Neuroscience, 2020 Chronic pain caused by spinal cord injury (SCI) is notoriously resistant to treatment, particularly by opioids. After SCI, DRG neurons show hyperactivity and chronic depolarization of resting membrane potential (RMP) that is maintained by cAMP signaling ...
Anibal Garza Carbajal +3 more
semanticscholar +1 more source
Fetal Pain Perception: Legislative Assertions and Developmental Neuroscience
Annals of the Child Neurology Society, EarlyView.ABSTRACT Background Pain perception is a conscious experience, but neither pain nor consciousness is defined in the developing human fetus. Emergent consciousness may be regarded as a phenomenon that ultimately arises from an essential minimum of functional neuronal connectivity. Proposed U.S.
William D. Graf +9 more
wiley +1 more source
A-Type KV Channels in Dorsal Root Ganglion Neurons: Diversity, Function, and Dysfunction [PDF]
, 2018 A-type voltage-gated potassium (Kv) channels are major regulators of neuronal excitability that have been mainly characterized in the central nervous system. By contrast, there is a paucity of knowledge about the molecular physiology of these Kv channels
Covarrubias, Manuel +3 more
core +1 more source
Philosophical Transactions of the Royal Society of London. Biological Sciences, 2019 Chronic pain is considered maladaptive by clinicians because it provides no apparent protective or recuperative benefits. Similarly, evolutionary speculations have assumed that chronic pain represents maladaptive or evolutionarily neutral dysregulation ...
E. Walters
semanticscholar +1 more source
Opioid-Induced Hyperalgesic Priming in Single Nociceptors
Journal of Neuroscience, 2020 Clinical µ-opioid receptor (MOR) agonists produce hyperalgesic priming, a form of maladaptive nociceptor neuroplasticity, resulting in pain chronification. We have established an in vitro model of opioid-induced hyperalgesic priming (OIHP), in male rats,
E. Khomula +3 more
semanticscholar +1 more source
Nociceptor neurons promote IgE class switch in B cells
JCI Insight, 2021 Nociceptors, the high-threshold primary sensory neurons that trigger pain, interact with immune cells in the periphery to modulate innate immune responses. Whether they also participate in adaptive and humoral immunity is, however, not known.
Shreya Mathur +10 more
doaj +1 more source
Fibromyalgia: A Unifying Neuroendocrinologic Model for Understanding Its Pathophysiology [PDF]
, 2008 Fibromyalgia is believed to affect at least 2% of the population. Despite advances in the scientific understanding of the derangements of central and peripheral pain processing mechanisms in fibromyalgia, no current models of its pathophysiology account ...
Peter Dorsher
core +1 more source
OP0195 TARGETED ABLATION OF KNEE-INNERVATING NOCICEPTORS HAS PROFOUND EFFECTS ON JOINT DAMAGE IN EXPERIMENTAL OSTEOARTHRITIS [PDF]
, 2023 Luwei Wang +5 more
openalex +1 more source
Journal of Periodontology, EarlyView.Abstract Background This first‐in‐human clinical study aimed to evaluate the safety and efficacy of a bioglass incorporated in a toothpaste, in reducing dentin hypersensitivity (DH) compared to a sodium fluoride (NaF) toothpaste over a 2‐week period. Methods A double‐blind, randomized, parallel‐arm, proof‐of‐concept clinical trial was conducted with 46
Hatice Hasturk +6 more
wiley +1 more source