Results 121 to 130 of about 40,810 (316)
Artificial Organs, EarlyView.Transverse placement of electrical muscle stimulation (EMS) electrodes across muscle fibers elicits localized contractions, facilitating greater active stretching (AS) of regions containing myofascial trigger points. This EMS + AS approach mimics passive stretching, with EMS providing resistance force similar to that typically applied by a therapist's ...
Seekaow Churproong +3 more
wiley +1 more source
Psilocybin as a novel treatment for chronic pain
British Journal of Pharmacology, EarlyView.Abstract Psychedelic drugs are under active consideration for clinical use and have generated significant interest for their potential as anti‐nociceptive treatments for chronic pain, and for addressing conditions like depression, frequently co‐morbid with pain.
Tate Askey +3 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Psoriasis is a chronic, relapsing, immune‐mediated inflammatory skin disease. The transient receptor potential ankyrin 1 (TRPA1) ion channel plays a protective role in the formation of psoriasiform skin reactions. Here, we investigated the pharmacological activation and blockade of TRPA1 in human skin (patho)physiology ...
Ágnes Kemény +10 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose Migraine is a neurovascular disorder largely mediated by calcitonin gene‐related peptide (CGRP). This study explores the role of the nociceptin/orphanin FQ (N/OFQ)–N/OFQ receptor (NOP) system in CGRP‐induced periorbital mechanical allodynia (PMA) in mice.
Chiara Sturaro +14 more
wiley +1 more source
Pain pathways and mechanisms of neuropathic pain
Acta Neurológica Colombiana, 2007 Several neural steps are involved in the processing of noxious signals that can lead to the experience of pain. Nociceptors readily respond to different noxious modalities such as thermal, mechanical or chemical stimuli, but nociceptors do not respond ...
Oscar A. de Leon-Casasola
doaj +2 more sources
Sex-specific nociceptor modulation of the apical periodontitis transcriptome
Frontiers in Molecular BiosciencesIntroduction: Apical periodontitis (AP) is a painful disease that develops quickly following dental infections and is primarily characterized by robust inflammation surrounding the tissues of the affected tooth, resulting in disruption of bone ...
Katherine V. Lillis +2 more
doaj +1 more source
Nociceptors: Their Role in Body’s Defenses, Tissue Specific Variations and Anatomical Update
Journal of Pain Research, 2022 Vladimir N Nikolenko,1,2 Ekaterina M Shelomentseva,2 Maria M Tsvetkova,2 Elina I Abdeeva,1 Dmitriy B Giller,1 Juliya V Babayeva,1 Evgeny E Achkasov,1 Liliya V Gavryushova,3 Mikhail Y Sinelnikov1,4 1First Moscow State Medical University Named After I.M ...
Nikolenko VN +8 more
doaj
A dominant role of acid pH in inflammatory excitation and sensitization of nociceptors in rat skin, in vitro [PDF]
, 1995 Steen Kh, AE Steen, Peter W. Reeh
openalex +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose The functional organization of corneal cold nerve endings, critical structures in maintaining the ocular surface, remains poorly understood. Here, the photoisomerizable small‐molecule diethylamine‐azobenzene‐quaternary ammonium (DENAQ) was used to photomodulate activity of cold‐sensing nerve terminals in control and chronic tear ...
David Ares‐Suárez +11 more
wiley +1 more source