Results 11 to 20 of about 49,496 (354)
Molecular Mechanisms Underlying the Pain-Relieving Effects of Extracorporeal Shock Wave Therapy: A Focus on Fascia Nociceptors [PDF]
Life, 2022 In recent years, extracorporeal shock wave therapy (ESWT) has received increasing attention for its potential beneficial effects on various bone and soft-tissue pathologies, yielding promising outcomes for pain relief and functional recovery.
Larisa Ryskalin +4 more
doaj +3 more sources
Role of TMEM100 in mechanically insensitive nociceptor un-silencing [PDF]
Nature Communications, 2023 Silent nociceptors remained enigmatic ever since they were first described decades ago. Here, Nees. et al. show that inflammation-induced upregulation of TMEM100 unsilences silent nociceptors, which triggers secondary mechanical pain hypersensitivity.
Timo A. Nees +17 more
doaj +2 more sources
BMP signaling downstream of the Highwire E3 ligase sensitizes nociceptors. [PDF]
PLoS Genetics, 2018 A comprehensive understanding of the molecular machinery important for nociception is essential to improving the treatment of pain. Here, we show that the BMP signaling pathway regulates nociception downstream of the E3 ubiquitin ligase highwire (hiw ...
Ken Honjo, W Daniel Tracey
doaj +4 more sources
Advancing the Understanding of Acupoint Sensitization and Plasticity Through Cutaneous C-Nociceptors
Frontiers in Neuroscience, 2022 Acupoint is the key area for needling treatment, but its physiology is not yet understood. Nociceptors, one of the responders in acupoints, are responsible for acupuncture manipulation and delivering acupuncture signals to the spinal or supraspinal level.
Xiang Cui, Kun Liu, Xinyan Gao, Bing Zhu
doaj +2 more sources
TTX-Resistant Sodium Channels Functionally Separate Silent From Polymodal C-nociceptors [PDF]
Frontiers in Cellular Neuroscience, 2020 Pronounced activity-dependent slowing of conduction has been used to characterize mechano-insensitive, “silent” nociceptors and might be due to high expression of NaV1.8 and could, therefore, be characterized by their tetrodotoxin-resistance (TTX-r ...
Robin Jonas +10 more
doaj +2 more sources
Cutaneous inflammation alters nociceptor electrophysiology in guinea pigs but not rats [PDF]
Biomolecules & BiomedicineInflammatory pain hypersensitivity is believed to result, in part, from increased excitability of nociceptive dorsal root ganglion (DRG) neurons. We previously demonstrated in guinea pigs that hindlimb inflammation induces electrophysiological changes ...
Laiche Djouhri +7 more
doaj +2 more sources
Spatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptors
Science Translational Medicine, 2022 Nociceptors are specialized sensory neurons that detect damaging or potentially damaging stimuli and are found in the dorsal root ganglia (DRG) and trigeminal ganglia.
Diana Tavares-Ferreira +14 more
semanticscholar +1 more source
Multimodal control of dendritic cell functions by nociceptors
Science, 2023 It is known that interactions between nociceptors and dendritic cells (DCs) can modulate immune responses in barrier tissues. However, our understanding of the underlying communication frameworks remains rudimentary.
P. Hanč +7 more
semanticscholar +1 more source
bioRxiv, 2023 Objective Knee joints are densely innervated by nociceptors. Sprouting of nociceptors has been reported in late-stage osteoarthritis (OA), both in human knees and in rodent models.
A. Obeidat +9 more
semanticscholar +1 more source