Results 21 to 30 of about 49,496 (354)
bioRxiv, 2023 Objective Knee joints are densely innervated by nociceptors. Sprouting of nociceptors has been reported in late-stage osteoarthritis (OA), both in human knees and in rodent models.
A. Obeidat +9 more
semanticscholar +1 more source
Pain perception in schizophrenia: A neglected phenomenon with a great impact
European Psychiatry, 2021 Introduction A decrease in pain sensitivity has been observed in patients with schizophrenia since the beginning of the twentieth century. This hypothesis further emerged during the last decades due to many clinical findings. Objectives To study pain
N. Faouel +4 more
doaj +1 more source
Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis
bioRxiv, 2022 Osteoarthritis is characterized by mechanically driven pain but lacks adequate treatments. Here, the authors show that inhibiting a mechanically-sensitive ion channel expressed by nociceptors reduces pain behaviors in mouse models of joint pain.
A. Obeidat +10 more
semanticscholar +1 more source
Studying human nociceptors: from fundamentals to clinic
Brain : a journal of neurology, 2021 Chronic pain affects one in five of the general population and is the third most important cause of disability-adjusted life-years globally. Unfortunately, treatment remains inadequate due to poor efficacy and tolerability.
Steven J. Middleton +11 more
semanticscholar +1 more source
Molecular taxonomy of nociceptors and pruriceptors
Pain, 2023 The ability to feel the warmth of the sun or the coolness of a breeze on a summer’s day; a pleasant caress of skin; to explore the texture, size, and shape of an object; and to feel pain as a mechanism to protect us from what is dangerous around us has ...
Jussi Kupari, P. Ernfors
semanticscholar +1 more source
Pathophysiology, 2022 Pain and nociception are different phenomena. Nociception is the result of complex activity in sensory pathways. On the other hand, pain is the effect of interactions between nociceptive processes, and cognition, emotions, as well as the social context ...
Marco Cascella +6 more
doaj +1 more source
Journal of Neuroscience, 2022 Neuropathic pain is a major, inadequately treated challenge for people with spinal cord injury (SCI). While SCI pain mechanisms are often assumed to be in the CNS, rodent studies have revealed mechanistic contributions from primary nociceptors.
A. Bavencoffe +7 more
semanticscholar +1 more source
Nociceptive Sensory Neurons Mediate Inflammation Induced by Bacillus Anthracis Edema Toxin
Frontiers in Immunology, 2021 Bacterial products are able to act on nociceptive neurons during pathogenic infection. Neurogenic inflammation is an active part of pain signaling and has recently been shown to impact host-pathogen defense.
Nicole J. Yang +7 more
doaj +1 more source
HMGB1 released from nociceptors mediates inflammation
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Nociceptors are sensory neurons that detect changes in the body’s internal and external milieu. Although occupying a primary role in signaling these changes to the nervous system, nociceptors also initiate neurogenic inflammation by sending ...
Huan Yang +17 more
semanticscholar +1 more source
GTL-1, a Calcium Activated TRPM Channel, Enhances Nociception
Frontiers in Pharmacology, 2020 C. elegans PVD neurons are conserved for morphology, function and molecular determinants with mammalian polymodal nociceptors. Functions of polymodal nociceptors require activities of multiple ion channels and receptors including members of the TRP ...
Emiliano Cohen +4 more
doaj +1 more source