Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli [PDF]
, 2009 Behavioral responses to painful stimuli require peripheral sensory neurons called nociceptors. Electrophysiological studies show that most C-fiber nociceptors are polymodal (i.e., respond to multiple noxious stimulus modalities, such as mechanical and ...
A. I. Basbaum +41 more
core +4 more sources
Functional and Molecular Characterization of Mechanoinsensitive “Silent” Nociceptors
Cell Reports, 2017 Mechanical and thermal hyperalgesia (pain hypersensitivity) are cardinal signs of inflammation. Although the mechanism underlying thermal hyperalgesia is well understood, the cellular and molecular basis of mechanical hyperalgesia is poorly described ...
Vincenzo Prato +10 more
doaj +1 more source
Emulating Nociceptive Receptor and LIF Neuron Behavior via ZrOx‐based Threshold Switching Memristor
Advanced Electronic Materials, 2023 For the progress of artificial neural networks, the imitation of multiple biological functions is indispensable for processing more tasks in a complex working environment.
Jia‐He Yang +3 more
doaj +1 more source
Nociceptive neuropeptide increases and periorbital allodynia in a model of traumatic brain injury. [PDF]
, 2012 OBJECTIVE: This study tests the hypothesis that injury to the somatosensory cortex is associated with periorbital allodynia and increases in nociceptive neuropeptides in the brainstem in a mouse model of controlled cortical impact (CCI) injury.
Amenta, Peter S. +4 more
core +2 more sources
Frontiers in Pain ResearchOrthodontic forces are strongly associated with pain, the primary complaint among patients wearing orthodontic braces. Compared to other side effects of orthodontic treatment, orthodontic pain is often overlooked, with limited clinical management ...
Sheng Wang +3 more
doaj +1 more source
Molecular Mechanisms That Contribute to Bone Marrow Pain
Frontiers in Neurology, 2017 Pain associated a bony pathology puts a significant burden on individuals, society, and the health-care systems worldwide. Pathology that involves the bone marrow activates sensory nerve terminal endings of peripheral bone marrow nociceptors, and is the ...
Jason J. Ivanusic
doaj +1 more source
Emergence of functional sensory subtypes as defined by transient receptor potential channel expression [PDF]
, 2007 The existence of heterogeneous populations of dorsal root ganglion (DRG) neurons conveying different somatosensory information is the basis for the perception of touch, temperature, and pain. A differential expression of transient receptor potential (TRP)
AlQatari, M +3 more
core +1 more source
GABA increases electrical excitability in a subset of human unmyelinated peripheral axons [PDF]
, 2010 A proportion of small diameter primary sensory neurones innervating human skin are chemosensitive. They respond in a receptor dependent manner to chemical mediators of inflammation as well as naturally occurring algogens, thermogens and pruritogens.
Carr, Richard W +3 more
core +7 more sources
Periosteal nociceptors induced hypotension and bradycardia under spinal anesthesia -A report of two cases- [PDF]
Korean Journal of Anesthesiology, 2011 The sudden hemodynamic disturbance in the perioperative period can occur because of various surgical and anesthetic reasons but hemodynamic collapse due to noxious stimulus of periosteum stripping has not been described.
Rakesh Garg +2 more
doaj +1 more source
Metabotropic glutamate receptor 2/3 (mGluR2/3) activation suppresses TRPV1 sensitization in mouse, but not human sensory neurons [PDF]
, 2018 The use of human tissue to validate putative analgesic targets identified in rodents is a promising strategy for improving the historically poor translational record of preclinical pain research.
Baranger, David A.A. +5 more
core +2 more sources