Contemporary management of pain in cirrhosis: Toward precision therapy for pain
Hepatology, EarlyView., 2022 Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman +4 more
wiley +1 more source
Meis1 Regulates Nociceptor Development and Behavioral Response to Tactile Stimuli
Frontiers in Molecular Neuroscience, 2022 Nociceptors in the dorsal root ganglia (DRG) and trigeminal ganglia (TG) are necessary for transmitting pain and itch signals. However, the molecular mechanism regulating nociceptor development remains largely unknown.
Zheng Cao +9 more
doaj +1 more source
Inhibiting endocytosis in CGRP+ nociceptors attenuates inflammatory pain-like behavior
Nature Communications, 2021 The advantage of locally applied anesthetics is that they are not associated with the many adverse effects, including addiction liability, of systemically administered analgesics.
Rasheen Powell +6 more
semanticscholar +1 more source
Spatial transcriptomics reveals unique molecular fingerprints of human nociceptors
bioRxiv, 2021 Nociceptors are specialized sensory neurons that detect damaging or potentially damaging stimuli and are found in the dorsal root (DRG) and trigeminal ganglia.
Diana Tavares-Ferreira +14 more
semanticscholar +1 more source
Deletion of Tsc2 in nociceptors reduces target innervation, ion channel expression, and sensitivity to heat [PDF]
, 2018 The mechanistic target of rapamycin complex 1 (mTORC1) is known to regulate cellular growth pathways, and its genetic activation is sufficient to enhance regenerative axon growth following injury to the central or peripheral nervous systems.
Carlin, Dan +6 more
core +2 more sources
γδ T Cells Participating in Nervous Systems: A Story of Jekyll and Hyde
Frontiers in Immunology, 2021 γδ T cells are distributed in various lymphoid and nonlymphoid tissues, and act as early responders in many conditions. Previous studies have proven their significant roles in infection, cancer, autoimmune diseases and tissue maintenance.
Yunxuan Li, Yixi Zhang, Xun Zeng
doaj +1 more source
On the G-protein-coupled receptor heteromers and their allosteric receptor-receptor interactions in the central nervous system: focus on their role in pain modulation [PDF]
, 2013 The modulatory role of allosteric receptor-receptor interactions in the pain pathways of the Central Nervous System and the peripheral nociceptors has become of increasing interest.
Agnati, Luigi F +6 more
core +3 more sources
Pain, 2020 SARS-CoV-2 has created a global crisis. COVID-19, the disease caused by the virus, is characterized by pneumonia, respiratory distress and hypercoagulation and can be fatal.
Stephanie I. Shiers +9 more
semanticscholar +1 more source
The Role of Kv7/M Potassium Channels in Controlling Ectopic Firing in Nociceptors
Frontiers in Molecular Neuroscience, 2017 Peripheral nociceptive neurons encode and convey injury-inducing stimuli toward the central nervous system. In normal conditions, tight control of nociceptive resting potential prevents their spontaneous activation.
Omer Barkai +11 more
doaj +1 more source
Cutaneous Neuroimmune Interactions in Peripheral Neuropathic Pain States
Frontiers in Immunology, 2021 Bidirectional interplay between the peripheral immune and nervous systems plays a crucial role in maintaining homeostasis and responding to noxious stimuli. This crosstalk is facilitated by a variety of cytokines, inflammatory mediators and neuropeptides.
Daniel B. Lowy +2 more
doaj +1 more source