Results 31 to 40 of about 40,810 (316)
SmartMat, 2023 Artificial synapses and neurons are crucial milestones for neuromorphic computing hardware, and memristors with resistive and threshold switching characteristics are regarded as the most promising candidates for the construction of hardware neural ...
Fu‐Dong Wang +11 more
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Advanced Science, 2022 A biological receptor serves as sensory transduction from an external stimulus to an electrical signal. It allows humans to better match the environment by filtering out repetitive innocuous information and recognize potentially damaging stimuli through ...
Young Geun Song +10 more
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Peripheralized sepiapterin reductase inhibition as a safe analgesic therapy
Frontiers in Pharmacology, 2023 The development of novel analgesics for chronic pain in the last 2 decades has proven virtually intractable, typically failing due to lack of efficacy and dose-limiting side effects.
Shane J. F. Cronin +2 more
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Nociceptive neuropeptide increases and periorbital allodynia in a model of traumatic brain injury. [PDF]
, 2012 OBJECTIVE: This study tests the hypothesis that injury to the somatosensory cortex is associated with periorbital allodynia and increases in nociceptive neuropeptides in the brainstem in a mouse model of controlled cortical impact (CCI) injury.
Amenta, Peter S. +4 more
core +2 more sources
Nanoscale all-oxide-heterostructured bio-inspired optoresponsive nociceptor [PDF]
, 2020 Retina nociceptor, as a key sensory receptor, not only enables the transport of warning signals to the human central nervous system upon its exposure to noxious stimuli, but also triggers the motor response that minimizes potential sensitization. In this
Hu, Jie +4 more
core +2 more sources
Acta Scientiarum. Health Sciences, 2012 Nervous System Mobilization is used to restore the biomechanics of the nervous system and adjacent structures, promoting the return to their duties. This study evaluated the pain threshold to pressure, to cold, and the cold pain intensity in healthy ...
Anaíma Lopes Frutos +3 more
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Translating nociceptor sensitivity: the role of axonal protein synthesis in nociceptor physiology [PDF]
European Journal of Neuroscience, 2009 AbstractThe increased sensitivity of peripheral pain‐sensing neurons, or nociceptors, is a major cause of the sensation of pain that follows injury. This plasticity is thought to contribute to the maintenance of chronic pain states. Although we have a broad knowledge of the factors that stimulate changes in nociceptor sensitivity, the cellular ...
Sandrine M Géranton, Theodore J. Price
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Emergence of functional sensory subtypes as defined by transient receptor potential channel expression [PDF]
, 2007 The existence of heterogeneous populations of dorsal root ganglion (DRG) neurons conveying different somatosensory information is the basis for the perception of touch, temperature, and pain. A differential expression of transient receptor potential (TRP)
AlQatari, M +3 more
core +1 more source
Contribution of Piezo2 to endothelium-dependent pain. [PDF]
, 2015 BackgroundWe evaluated the role of a mechanically-gated ion channel, Piezo2, in mechanical stimulation-induced enhancement of hyperalgesia produced by the pronociceptive vasoactive mediator endothelin-1, an innocuous mechanical stimulus-induced ...
Bogen, Oliver +3 more
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Nociceptors—Noxious Stimulus Detectors [PDF]
Neuron, 2007 In order to deal effectively with danger, it is imperative to know about it. This is what nociceptors do--these primary sensory neurons are specialized to detect intense stimuli and represent, therefore, the first line of defense against any potentially threatening or damaging environmental inputs.
Qiufu Ma, Clifford J. Woolf
openaire +3 more sources