Results 41 to 50 of about 40,810 (316)

Functional and Molecular Characterization of Mechanoinsensitive “Silent” Nociceptors

Cell Reports, 2017
Mechanical and thermal hyperalgesia (pain hypersensitivity) are cardinal signs of inflammation. Although the mechanism underlying thermal hyperalgesia is well understood, the cellular and molecular basis of mechanical hyperalgesia is poorly described ...
Vincenzo Prato, Francisco J. Taberner, James R.F. Hockley, Gerard Callejo, Alice Arcourt, Bassim Tazir, Leonie Hammer, Paulina Schad, Paul A. Heppenstall, Ewan S. Smith, Stefan G. Lechner   +10 more
doaj   +1 more source

Deletion of annexin 2 light chain p11 in nociceptors causes deficits in somatosensory coding and pain behavior [PDF]

, 2006
The S100 family protein p11 (S100A10, annexin 2 light chain) is involved in the trafficking of the voltage-gated sodium channel Na(V)1.8, TWIK-related acid-sensitive K+ channel (TASK-1), the ligand-gated ion channels acid-sensing ion channel 1a (ASIC1a ...
Baker, MD, Dickenson, AH, Foulkes, T, Gerke, V, Lane, T, Matthews, EA, Nassar, MA, Okuse, K, Wood, JN   +8 more
core   +1 more source

Nociceptor mechanisms underlying pain and bone remodeling via orthodontic forces: toward no pain, big gain

Frontiers in Pain Research
Orthodontic forces are strongly associated with pain, the primary complaint among patients wearing orthodontic braces. Compared to other side effects of orthodontic treatment, orthodontic pain is often overlooked, with limited clinical management ...
Sheng Wang, Ching-Chang Ko, Man-Kyo Chung, Man-Kyo Chung   +3 more
doaj   +1 more source

Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli [PDF]

, 2009
Behavioral responses to painful stimuli require peripheral sensory neurons called nociceptors. Electrophysiological studies show that most C-fiber nociceptors are polymodal (i.e., respond to multiple noxious stimulus modalities, such as mechanical and ...
A. I. Basbaum, Abrahamsen, Barclay, Bautista, Bautista, Binshtok, Cain, Caterina, Caterina, Caterina, Caterina, Caterina, Chandrashekar, D. J. Anderson, D. J. Cavanaugh, Davis, Dong, Fitzgerald, Gamse, H. Lee, Holzer, Julius, Karai, L. Lo, Lawson, Lee, Lewinter, Luquet, M. J. Zylka, MELZACK, Molliver, Perl, Perl, Potrebic, Price, S. D. Shields, Saito, Story, Stucky, Tarpley, Vulchanova, Yaksh   +41 more
core   +4 more sources

Molecular Mechanisms That Contribute to Bone Marrow Pain

Frontiers in Neurology, 2017
Pain associated a bony pathology puts a significant burden on individuals, society, and the health-care systems worldwide. Pathology that involves the bone marrow activates sensory nerve terminal endings of peripheral bone marrow nociceptors, and is the ...
Jason J. Ivanusic
doaj   +1 more source

Nociceptor neurons promote IgE class switch in B cells

JCI Insight, 2021
Nociceptors, the high-threshold primary sensory neurons that trigger pain, interact with immune cells in the periphery to modulate innate immune responses. Whether they also participate in adaptive and humoral immunity is, however, not known.
Shreya Mathur, Jo-Chiao Wang, Corey R. Seehus, Florence Poirier, Theo Crosson, Yu-Chen Hsieh, Benjamin Doyle, Seungkyu Lee, Clifford J. Woolf, Simmie L. Foster, Sebastien Talbot   +10 more
doaj   +1 more source

Periosteal nociceptors induced hypotension and bradycardia under spinal anesthesia -A report of two cases- [PDF]

Korean Journal of Anesthesiology, 2011
The sudden hemodynamic disturbance in the perioperative period can occur because of various surgical and anesthetic reasons but hemodynamic collapse due to noxious stimulus of periosteum stripping has not been described.
Rakesh Garg, Pradeep Karunagaran, Mridula Pawar   +2 more
doaj   +1 more source

Mrgprd Enhances Excitability in Specific Populations of Cutaneous Murine Polymodal Nociceptors [PDF]

, 2009
The Mas-related G protein-coupled receptor D (Mrgprd) is selectively expressed in nonpeptidergic nociceptors that innervate the outer layers of mammalian skin.
Anderson, David J., Jankowski, Michael P., Koerber, H. Richard, Lawson, Jeffrey J., McIlwrath, Sabrina L., Rau, Kristofer K., Wang, Hong, Zylka, Mark J.   +7 more
core   +3 more sources

Emulating Nociceptive Receptor and LIF Neuron Behavior via ZrOx‐based Threshold Switching Memristor

Advanced Electronic Materials, 2023
For the progress of artificial neural networks, the imitation of multiple biological functions is indispensable for processing more tasks in a complex working environment.
Jia‐He Yang, Shi‐Cheng Mao, Kuan‐Ting Chen, Jen‐Sue Chen   +3 more
doaj   +1 more source

Contemporary views on inflammatory pain mechanisms: TRPing over innate and microglial pathways. [PDF]

, 2016
Tissue injury, whether by trauma, surgical intervention, metabolic dysfunction, ischemia, or infection, evokes a complex cellular response (inflammation) that is associated with painful hyperalgesic states.
Guan, Zhonghui, Hellman, Judith, Schumacher, Mark   +2 more
core   +2 more sources