Results 41 to 50 of about 49,496 (354)
Epineural optogenetic activation of nociceptors initiates and amplifies inflammation
Nature Biotechnology, 2020 Activation of nociceptor sensory neurons by noxious stimuli both triggers pain and increases capillary permeability and blood flow to produce neurogenic inflammation 1 , 2 , but whether nociceptors also interact with the immune system remains poorly ...
F. Michoud +18 more
semanticscholar +1 more source
Loss of Prdm12 during development, but not in mature nociceptors, causes defects in pain sensation
Cell Reports, 2021 Summary: Prdm12 is a key transcription factor in nociceptor neurogenesis. Mutations of Prdm12 cause congenital insensitivity to pain (CIP) from failure of nociceptor development.
Mark A. Landy +4 more
doaj +1 more source
Intense isolectin-B4 binding in rat dorsal root ganglion neurons distinguishes c-fiber nociceptors with broad action potentials and high nav1.9 expression [PDF]
, 2006 Binding to isolectin-B4 (IB4) and expression of tyrosine kinase A (trkA) (the high-affinity NGF receptor) have been used to define two different subgroups of nociceptive small dorsal root ganglion (DRG) neurons. We previously showed that only nociceptors
Berry, Carol +6 more
core +1 more source
SmartMat, 2023 Artificial synapses and neurons are crucial milestones for neuromorphic computing hardware, and memristors with resistive and threshold switching characteristics are regarded as the most promising candidates for the construction of hardware neural ...
Fu‐Dong Wang +11 more
doaj +1 more source
Frontiers in Physiology, 2012 Spinal cord injury (SCI) causes chronic peripheral sensitization of nociceptors and persistent generation of spontaneous action potentials (SA) in peripheral branches and the somata of hyperexcitable nociceptors within dorsal root ganglia (DRG).
Edgar T Walters
doaj +1 more source
Conditional gene deletion reveals functional redundancy of GABAB receptors in peripheral nociceptors in vivo [PDF]
, 2009 Background Gamma-aminobutyric acid (GABA) is an important inhibitory neurotransmitter which mainly mediates its effects on neurons via ionotropic (GABAA) and metabotropic (GABAB) receptors.
Bernhard Bettler +9 more
core +3 more sources
Advanced Science, 2022 A biological receptor serves as sensory transduction from an external stimulus to an electrical signal. It allows humans to better match the environment by filtering out repetitive innocuous information and recognize potentially damaging stimuli through ...
Young Geun Song +10 more
doaj +1 more source
Peripheralized sepiapterin reductase inhibition as a safe analgesic therapy
Frontiers in Pharmacology, 2023 The development of novel analgesics for chronic pain in the last 2 decades has proven virtually intractable, typically failing due to lack of efficacy and dose-limiting side effects.
Shane J. F. Cronin +2 more
doaj +1 more source
Use of Capsaicin to Treat Pain: Mechanistic and Therapeutic Considerations
Pharmaceuticals, 2016 Capsaicin is the pungent ingredient of chili peppers and is approved as a topical treatment of neuropathic pain. The analgesia lasts for several months after a single treatment. Capsaicin selectively activates TRPV1, a Ca2+-permeable cationic ion channel
Man-Kyo Chung, James N. Campbell
doaj +1 more source
Deletion of annexin 2 light chain p11 in nociceptors causes deficits in somatosensory coding and pain behavior [PDF]
, 2006 The S100 family protein p11 (S100A10, annexin 2 light chain) is involved in the trafficking of the voltage-gated sodium channel Na(V)1.8, TWIK-related acid-sensitive K+ channel (TASK-1), the ligand-gated ion channels acid-sensing ion channel 1a (ASIC1a ...
Baker, MD +8 more
core +1 more source