Results 41 to 50 of about 41,919 (235)
Contribution of Piezo2 to endothelium-dependent pain. [PDF]
, 2015 BackgroundWe evaluated the role of a mechanically-gated ion channel, Piezo2, in mechanical stimulation-induced enhancement of hyperalgesia produced by the pronociceptive vasoactive mediator endothelin-1, an innocuous mechanical stimulus-induced ...
Bogen, Oliver +3 more
core +2 more sources
Molecular Pain, 2010 Background The cellular and molecular programs that control specific types of pain are poorly understood. We reported previously that the runt domain transcription factor Runx1 is initially expressed in most nociceptors and controls sensory neuron ...
Arber Silvia +5 more
doaj +1 more source
Contemporary views on inflammatory pain mechanisms: TRPing over innate and microglial pathways. [PDF]
, 2016 Tissue injury, whether by trauma, surgical intervention, metabolic dysfunction, ischemia, or infection, evokes a complex cellular response (inflammation) that is associated with painful hyperalgesic states.
Guan, Zhonghui +2 more
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Innate Receptors Expression by Lung Nociceptors: Impact on COVID-19 and Aging
Frontiers in Immunology, 2021 The lungs are constantly exposed to non-sterile air which carries harmful threats, such as particles and pathogens. Nonetheless, this organ is equipped with fast and efficient mechanisms to eliminate these threats from the airways as well as prevent ...
Carlos H. Hiroki +7 more
doaj +1 more source
High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain [PDF]
, 2007 Little is known about the molecular basis of somatosensory mechanotransduction in mammals. We screened a library of peptide toxins for effects on mechanically activated currents in cultured dorsal root ganglion neurons.
Abrahamsen, B +11 more
core
Control of myeloid cell functions by nociceptors
Frontiers in Immunology, 2023 The immune system has evolved to protect the host from infectious agents, parasites, and tumor growth, and to ensure the maintenance of homeostasis.
Pavel Hanč +7 more
doaj +1 more source
On The Content and Character of Pain Experience [PDF]
, 2019 Tracking representationalism explains the negative affective character of pain, and its capacity to motivate action, by reference to the representation of the badness for us of bodily damage.
Gray, Richard
core +3 more sources
Quantitative sensory testing in painful hand osteoarthritis demonstrates features of peripheral sensitisation. [PDF]
, 2012 Hand osteoarthritis (HOA) is a prevalent condition for which treatments are based on analgesia and physical therapies. Our primary objective was to evaluate pain perception in participants with HOA by assessing the characteristics of nodal involvement ...
Ejindu, V +5 more
core +2 more sources
Frontiers in Molecular BiosciencesThis review delves into the intricate biological underpinnings of pain perception. It encompasses nociceptive signaling pathways, the molecular mechanisms involved, and the subjective experience of discomfort in humans. The initial focus is on nociceptor
Bahar Dehghan +3 more
doaj +1 more source
P2 purinoceptors signaling in fibroblasts of rat subcutaneous tissue [PDF]
, 2011 Mestrado em Biologia Molecular e CelularO tecido conjuntivo parece estar envolvido na génese de diversas condições patológicas. O aumento da rigidez do tecido conjuntivo, resultante da fibrose, pode constituir um factor importante no mecanismo patogénico
Reis, Carla Patrícia da Silva e Sousa
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